Reduced Iodinated Contrast Media Administration in Coronary CT Angiography on a Clinical Photon-Counting Detector CT System: A Phantom Study Using a Dynamic Circulation Model

From the ∗Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston

†Department of Diagnostic and Interventional Radiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany

‡German Centre for Cardiovascular Research, Partner site Rhine-Main, Mainz, Germany

§Siemens Medical Solutions USA Inc, Malvern, PA

∥Siemens Healthineers, Forchheim, Germany.

Received for publication May 8, 2022; and accepted for publication, after revision, July 3, 2022.

Conflicts of interest and sources of funding: This work was supported by a research grant from Siemens Healthineers. U. Joseph Schoepf receives institutional research support and/or personal fees from Bayer, Bracco, Elucid Bioimaging, Guerbet, HeartFlow, Inc, Keya Medical, and Siemens. Akos Varga-Szemes receives institutional research support and/or personal fees from Bayer, Elucid Bioimaging, and Siemens. Tilman Emrich received a speaker fee and travel support from Siemens Medical Solutions USA Inc. Jim O’Doherty is an employee of Siemens Medical Solutions USA Inc. Thomas Allmendinger, Tristan Nowak, Bernhard Schmidt, and Thomas Flohr are employees of Siemens Healthineers.

Availability of data and materials: The datasets during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Authors' contributions: T.E., J.O.D., and A.V.S. designed the study, interpreted the study data, and drafted the manuscript. P.S. and G.A. acquired data and substantially revised the manuscript. R.K. and M.H. performed data analysis, supported statistical analysis, and substantially revised the manuscript. T.A., B.S., and T.F. advised data reconstruction, supervised data analysis, and edited/revised the manuscript. U.J.S. supervised the study conception and data interpretation and substantially edited the manuscript.

All authors read and approved the final manuscript.

Correspondence to: U. Joseph Schoepf, MD, Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Drive, MSC 226, Charleston, SC 29425-2260. E-mail: [email protected].

Supplemental digital contents are available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.investigativeradiology.com).

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