Histopathology: Deep machine learning based semantic segmentation features predict patient survival

Abstract

In this paper, we use deep learning techniques to segment different regions from breast cancer histopathology images, such as tumor nucleus, epithelium and stromal areas. Then, in the second stage, the deep segmentation features learned by the neural network are used to predict individual patient survival, using random forest based classification. We show that the deep segmentation network features can predict survival very well, and outperform classical computer vision based shape, texture and other feature descriptors used in earlier research for the same survival prediction task.

Competing Interest Statement

The authors have declared no competing interest.

Funding Statement

This study did not receive any funding

Author Declarations

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Yes

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Yes

I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

Yes

I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.

Yes

Data Availability

All data produced are available online

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