Mattson MP. Perspective: does brown fat protect against diseases of aging? Ageing Res Rev. 2010;9(1):69–76.
Roh E, Kim MS. Brain regulation of energy metabolism. Endocrinol Metab (Seoul). 2016;31(4):519–24.
Robertson SA, Leinninger GM, Myers MG Jr. Molecular and neural mediators of leptin action. Physiol Behav. 2008;94(5):637–42.
Belgardt BF, Bruning JC. CNS leptin and insulin action in the control of energy homeostasis. Ann N Y Acad Sci. 2010;1212:97–113.
Van Someren EJ. Thermoregulation and aging. Am J Physiol Regul Integr Comp Physiol. 2007;292(1):R99-102.
Osilla EV, JL Marsidi, S Sharma, Physiology, temperature regulation. StatPearls. 2022: Treasure Island (FL).
Rosenbaum M, Leibel RL. Adaptive thermogenesis in humans. Int J Obes (Lond). 2010;34(Suppl 1):S47-55.
Chong AC, Greendyk RA, Zeltser LM. Distinct networks of leptin- and insulin-sensing neurons regulate thermogenic responses to nutritional and cold challenges. Diabetes. 2015;64(1):137–46.
Han Y, et al. Deciphering an AgRP-serotoninergic neural circuit in distinct control of energy metabolism from feeding. Nat Commun. 2021;12(1):3525.
Yu S, et al. The hypothalamic preoptic area and body weight control. Neuroendocrinol. 2018;106(2):187–94.
Kuperman Y, et al. CRFR1 in AgRP neurons modulates sympathetic nervous system activity to adapt to cold stress and fasting. Cell Metab. 2016;23(6):1185–99.
Bartke A, Brown-Borg H. Life extension in the dwarf mouse. Curr Top Dev Biol. 2004;63:189–225.
Waters MJ, et al. New insights into growth hormone action. J Mol Endocrinol. 2006;36(1):1–7.
Darcy J, et al. Brown adipose tissue function is enhanced in long-lived, male Ames dwarf mice. Endocrinol. 2016;157(12):4744–53.
Darcy J, et al. Increased environmental temperature normalizes energy metabolism outputs between normal and Ames dwarf mice. Aging (Albany NY). 2018;10(10):2709–22.
Westbrook R, et al. Alterations in oxygen consumption, respiratory quotient, and heat production in long-lived GHRKO and Ames dwarf mice, and short-lived bGH transgenic mice. J Gerontol A Biol Sci Med Sci. 2009;64(4):443–51.
Furigo IC, et al. Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons. Nat Commun. 2019;10(1):662.
de Lima JBM, et al. Hypothalamic GHR-SIRT1 axis in fasting. Cells. 2021; 10(4).
List EO, et al. Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles. Endocrinol. 2014;155(5):1793–805.
Sadagurski M, Cady G, Miller RA. Anti-aging drugs reduce hypothalamic inflammation in a sex-specific manner. Aging Cell. 2017;16(4):652–60.
Sadagurski M, et al. Human IL6 enhances leptin action in mice. Diabetologia. 2010;53(3):525–35.
Schneider A, et al. Growth hormone signaling shapes the impact of environmental temperature on transcriptomic profile of different adipose tissue depots in male mice. J Gerontol: Series A. 2021;77(5):941–6.
Sanchez-Alavez M, Alboni S, Conti B. Sex- and age-specific differences in core body temperature of C57Bl/6 mice. Age (Dordr). 2011;33(1):89–99.
Klein Hazebroek M, Keipert S. Adapting to the cold: a role for endogenous fibroblast growth factor 21 in thermoregulation? Front Endocrinol (Lausanne). 2020;11:389.
Deem JD, et al. Cold-induced hyperphagia requires AgRP neuron activation in mice. Elife. 2020;9.
Zimmer MR, et al. Functional ontogeny of hypothalamic Agrp neurons in neonatal mouse behaviors. Cell. 2019;178(1):44–59 (e7).
Timper K, Bruning JC. Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity. Dis Model Mech. 2017;10(6):679–89.
de Lima JBM, et al. ARCGHR neurons regulate muscle glucose uptake. Cells. 2021;10(5):1093.
Furigo IC, et al. Growth hormone enhances the recovery of hypoglycemia via ventromedial hypothalamic neurons. FASEB J. 2019; fj201901315R.
Wasinski F, et al. Growth hormone receptor deletion reduces the density of axonal projections from hypothalamic arcuate nucleus neurons. Neurosci. 2020;434:136–47.
Dietrich MO, et al. Hypothalamic Agrp neurons drive stereotypic behaviors beyond feeding. Cell. 2015;160(6):1222–32.
Cavalcanti-de-Albuquerque JP, et al. Regulation of substrate utilization and adiposity by Agrp neurons. Nat Commun. 2019;10(1):311.
Graja A, Schulz TJ. Mechanisms of aging-related impairment of brown adipocyte development and function. Gerontol. 2015;61(3):211–7.
Burke LK, et al. mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice. Elife. 2017;6.
Dominick G, et al. Regulation of mTOR activity in Snell dwarf and GH receptor gene-disrupted mice. Endocrinol. 2015;156(2):565–75.
Campbell JN, et al. A molecular census of arcuate hypothalamus and median eminence cell types. Nat Neurosci. 2017;20(3):484–96.
Shi H, et al. Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis. Am J Physiol Endocrinol Metab. 2008;294(3):E630–9.
van de Wall E, et al. Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinol. 2008;149(4):1773–85.
Leung KC, et al. Estrogen regulation of growth hormone action. Endocr Rev. 2004;25(5):693–721.
Olofsson LE, Pierce AA, Xu AW. Functional requirement of AgRP and NPY neurons in ovarian cycle-dependent regulation of food intake. Proc Natl Acad Sci U S A. 2009;106(37):15932–7.
Kruijver FP, Swaab DF. Sex hormone receptors are present in the human suprachiasmatic nucleus. Neuroendocrinol. 2002;75(5):296–305.
Morselli LL, et al. Control of energy expenditure by AgRP neurons of the arcuate nucleus: neurocircuitry, signaling pathways, and angiotensin. Curr Hypertens Rep. 2018;20(3):25.
Yan C, Chen J, Chen N. Long noncoding RNA MALAT1 promotes hepatic steatosis and insulin resistance by increasing nuclear SREBP-1c protein stability. Sci Rep. 2016;6:22640.
Wang X, et al. Regulation of ANKRD9 expression by lipid metabolic perturbations. BMB Rep. 2009;42(9):568–73.
Yu XH, et al. LncRNA kcnq1ot1 promotes lipid accumulation and accelerates atherosclerosis via functioning as a ceRNA through the miR-452-3p/HDAC3/ABCA1 axis. Cell Death Dis. 2020;11(12):1043.
Ghimire S, Kim J. PEG3 controls lipogenesis through ACLY. PLoS One. 2021;16(5):e0252354.
Alshahrani S, et al. Increased Slc12a1 expression in beta-cells and improved glucose disposal in Slc12a2 heterozygous mice. J Endocrinol. 2015;227(3):153–65.
Flowers MT, Ntambi JM. Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism. Curr Opin Lipidol. 2008;19(3):248–56.
Lee SH, et al. Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment. J Lipid Res. 2004;45(9):1674–82.
Tran LT, et al. Hypothalamic control of energy expenditure and thermogenesis. Exp Mol Med. 2022;54(4):358–69.
Yasuda T, et al. Centrally administered ghrelin suppresses sympathetic nerve activity in brown adipose tissue of rats. Neurosci Lett. 2003;349(2):75–8.
Nelson CN, et al. Growth hormone activated STAT5 is required for induction of beige fat in vivo. Growth Horm IGF Res. 2018;42–43:40–51.
Li Y, Knapp JR, Kopchick JJ. E
留言 (0)