Angelova PR, Horrocks MH, Klenerman D, Gandhi S, Abramov AY, Shchepinov MS (2015) Lipid peroxidation is essential for alpha-synuclein-induced cell death. J Neurochem 133:582–589. https://doi.org/10.1111/jnc.13024

Article  CAS  Google Scholar 

Askarpour M, Ghaedi E, Roshanravan N, Hadi A, Mohammadi H, Symonds ME, Miraghajani M (2019) Policosanol supplementation significantly improves blood pressure among adults: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 45:89–97. https://doi.org/10.1016/j.ctim.2019.05.023

Article  Google Scholar 

Bartels T (2019) Alpha-Synuclein Methods and Protocols. Humana Press, New York. https://doi.org/10.1007/978-1-4939-9124-2

Book  Google Scholar 

Blum D, Torch S, Lambeng N, Nissou M, Benabid AL, Sadoul R, Verna JM (2001) Molecular pathways involved in the neurotoxicity of 6-OHDA, Molecular pathways involved in the neurotoxicity of 6-OHDA. Prog Neurobiol 65:135–172. https://doi.org/10.1016/s0301-0082(01)00003-x

Article  CAS  Google Scholar 

Castano G, Arruzazabala ML, Fernandez L, Mas R, Carbajal D, Molina V, Illnait J, Mendoza S, Gamez R, Mesa M, Fernandes S (2006) Effects of Combination Treatment with Policosanol and Omega-3 Fatty Acids on Platelet Aggregation A Randomized, Double-Blind Clinical Study. Curr Ther Res Clin Exp 67:174–192. https://doi.org/10.1016/j.curtheres.2006.06.004

Article  CAS  Google Scholar 

Chalorak P, Jattujan P, Nobsathian S, Poomtong T, Sobhon P, Meemon K (2018) Holothuria scabra extracts exhibit anti-Parkinson potential in C. elegans: A model for anti-Parkinson testing. Nutr Neurosci 21:427–438. https://doi.org/10.1080/1028415X.2017.1299437

Article  CAS  Google Scholar 

Chalorak P, Dharmasaroja P, Meemon K (2020) Downregulation of eEF1A/EFT3–4 Enhances Dopaminergic Neurodegeneration After 6-OHDA Exposure in C. elegans Model. Front Neurosci 14:303. https://doi.org/10.3389/fnins.2020.00303

Article  Google Scholar 

Chang CH, Wei CC, Ho CT, Liao VH (2021) N-gamma-(L-glutamyl)-L-selenomethionine shows neuroprotective effects against Parkinson’s disease associated with SKN-1/Nrf2 and TRXR-1 in Caenorhabditis elegans. Phytomedicine 92:153733. https://doi.org/10.1016/j.phymed.2021.153733

Article  CAS  Google Scholar 

Chen XM (2011) Natural population ecology of Ericerus pela. Science Press, Beijing

Google Scholar 

Chen XM, Feng Y (2009) An introduction to resource entomology. Science Press, Beijing

Google Scholar 

Chen F, Hersh BM, Conradt B, Zhou Z, Riemer D, Gruenbaum Y, Horvitz HR (2000) Translocation of C. elegans CED-4 to Nuclear Membranes During Programmed Cell Death. Science 287:1485–1489. https://doi.org/10.1126/science.287.5457.1485

Article  CAS  Google Scholar 

Cho KH, Kim SJ, Yadav D, Kim JY, Kim JR (2018) Consumption of Cuban Policosanol Improves Blood Pressure and Lipid Profile via Enhancement of HDL Functionality in Healthy Women Subjects: Randomized, Double-Blinded, and Placebo-Controlled Study. Oxid Med Cell Longev 2018:4809525. https://doi.org/10.1155/2018/4809525

Article  CAS  Google Scholar 

Ciulla M, Marinelli L, Cacciatore I, Stefano AD (2019) Role of Dietary Supplements in the Management of Parkinson's Disease. Biomolecules 9. https://doi.org/10.3390/biom9070271

Cooper JF, Van Raamsdonk JM (2018) Modeling Parkinson’s Disease in C. elegans. J Parkinsons Dis 8:17–32. https://doi.org/10.3233/JPD-171258

Article  CAS  Google Scholar 

de Lau LML, Breteler MMB (2006) Epidemiology of Parkinson’s disease. Lancet Neurol 5:525–535. https://doi.org/10.1016/s1474-4422(06)70471-9

Article  Google Scholar 

Devos D, Hirsch E, Wyse R (2021) Seven Solutions for Neuroprotection in Parkinson’s Disease. Mov Disord 36:306–316. https://doi.org/10.1002/mds.28379

Article  Google Scholar 

Duangjan C, Rangsinth P, Gu X, Zhang S, Wink M, Tencomnao T (2019) Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways. Phytomedicine 64. https://doi.org/10.1016/j.phymed.2019.153061

Escorcia W, Ruter DL, Nhan J, Curran SP (2018) Quantification of Lipid Abundance and Evaluation of Lipid Distribution in Caenorhabditis elegans by Nile Red and Oil Red O Staining. J Vis Exp. https://doi.org/10.3791/57352

Article  Google Scholar 

Farrer MJ (2006) Genetics of Parkinson disease: paradigm shifts and future prospects. Nat Rev Genet 7:306–318. https://doi.org/10.1038/nrg1831

Article  CAS  Google Scholar 

Flower TR, Chesnokova LS, Froelich CA, Dixon C, Witt SN (2005) Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson’s disease. J Mol Biol 351:1081–1100. https://doi.org/10.1016/j.jmb.2005.06.060

Article  CAS  Google Scholar 

Galvagnion C (2017) The Role of Lipids Interacting with alpha-Synuclein in the Pathogenesis of Parkinson’s Disease. J Parkinsons Dis 7:433–450. https://doi.org/10.3233/JPD-171103

Article  CAS  Google Scholar 

Gong J, Qin X, Yuan F, Hu M, Chen G, Fang K, Wang D, Jiang S, Li J, Zhao Y, Huang Z, Dong H, Lu F (2018) Efficacy and safety of sugarcane policosanol on dyslipidemia: A meta-analysis of randomized controlled trials. Mol Nutr Food Res 62. https://doi.org/10.1002/mnfr.201700280

González R, Paz M, Amiela T, Morera F, Illnait J (2018) Effect of policosanol (20 mg/d) on the functional recovery of patients with ischemic stroke: a one year study. Revista CENIC Ciencias Biologicas 49:1–14

Google Scholar 

Gouni-Berthold I, Berthold HK (2002) Policosanol: clinical pharmacology and therapeutic significance of a new lipid-lowering agent. Am Heart J 143:356–365. https://doi.org/10.1067/mhj.2002.119997

Article  CAS  Google Scholar 

Granja AL, Hernandez JM, Quintana DC, Valmana LA, Ferreiro RM, Mesa MG (1999) A mixture of higher primary aliphatic alcohols, its obtention from sugar cane wax and its pharmaceutical uses. Patent Publication No: AU711756B2

Hartman JH, Gonzalez-Hunt C, Hall SM, Ryde IT, Caldwell KA, Caldwell GA, Meyer JN (2019) Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration. Int J Mol Sci 20. https://doi.org/10.3390/ijms20133202

Hayes MT (2019) Parkinson’s Disease and Parkinsonism. Am J Med 132:802–807. https://doi.org/10.1016/j.amjmed.2019.03.001

Article  Google Scholar 

Kabir Y (2020) Health Benefits of Octacosanol and Other Long-Chain Aliphatic Fatty Alcohols from Plants. Springer Nature, Singapore

Book  Google Scholar 

Kampkotter A, Pielarski T, Rohrig R, Timpel C, Chovolou Y, Watjen W, Kahl R (2007) The Ginkgo biloba extract EGb761 reduces stress sensitivity, ROS accumulation and expression of catalase and glutathione S-transferase 4 in Caenorhabditis elegans. Pharmacol Res 55:139–147. https://doi.org/10.1016/j.phrs.2006.11.006

Article  CAS  Google Scholar 

Kim JY, Kim SM, Kim SJ, Lee EY, Kim JR, Cho KH (2017) Consumption of policosanol enhances HDL functionality via CETP inhibition and reduces blood pressure and visceral fat in young and middle-aged subjects. Int J Mol Med 39:889–899. https://doi.org/10.3892/ijmm.2017.2907

Article  CAS  Google Scholar 

Kim SK, van Ham TJ, Thijssen KL, Breitling R, Hofstra RMW, Plasterk RHA, Nollen EAA (2008) C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging. PLoS Genetics 4. https://doi.org/10.1371/journal.pgen.1000027

Kim SJ, Yadav D, Park HJ, Kim JR, Cho KH (2018) Long-Term Consumption of Cuban Policosanol Lowers Central and Brachial Blood Pressure and Improves Lipid Profile With Enhancement of Lipoprotein Properties in Healthy Korean Participants. Front Physiol 9. https://doi.org/10.3389/fphys.2018.00412

Lang AE, Espay AJ (2018) Disease Modification in Parkinson’s Disease: Current Approaches, Challenges, and Future Considerations. Mov Disord 33:660–677. https://doi.org/10.1002/mds.27360

Article  Google Scholar 

Li H, Shi R, Ding F, Wang H, Han W, Ma F, Hu M, Ma CW, Huang Z (2016) Astragalus Polysaccharide Suppresses 6-Hydroxydopamine-Induced Neurotoxicity in Caenorhabditis elegans. Oxid Med Cell Longev 2016:4856761. https://doi.org/10.1155/2016/4856761

Article  CAS  Google Scholar 

Ligaard J, Sannaes J, Pihlstrom L (2019) Deep brain stimulation and genetic variability in Parkinson’s disease: a review of the literature. NPJ Parkinsons Dis 5:18. https://doi.org/10.1038/s41531-019-0091-7

Article  CAS  Google Scholar 

Lu L, Shu C, Chen L, Yang Y, Ma S, Zhu K, Shi B (2020) Insecticidal activity and mechanism of cinnamaldehyde in C. elegans. Fitoterapia 146:104687. https://doi.org/10.1016/j.fitote.2020.104687

Article  CAS  Google Scholar 

Ludtmann MHR, Abramov AY (2018) Mitochondrial calcium imbalance in Parkinson’s disease. Neurosci Lett 663:86–90. https://doi.org/10.1016/j.neulet.2017.08.044

Article  CAS  Google Scholar 

Ma JJ, Ma LY, Zhang H, Zhang ZQ, Wang YQ (2018a) The preparation and evaluation of efficacy on skin wound healing in mice of insect wax compound ointment. Journal of Environmental Entomology 40:1238–1247. https://doi.org/10.3969/j.issn.1674-0858.2018.06.6

Article  Google Scholar 

Ma J, Wang R, Chen T, Jiang S, Xu A (2021) Protective effects of baicalin in a Caenorhabditis elegans model of Parkinson’s disease. Toxicol Res (camb) 10:409–417. https://doi.org/10.1093/toxres/tfaa107

Article  Google Scholar 

Ma JJ, Li K, Zhang WW, Ma LY, Xu J, Liu LX, Chen XM, Zhang H (2022) Acute toxicity and chromosomal aberration toxicity of insect wax and its policosanol. Food Sci Human Wellness 11:356–365. https://doi.org/10.1016/j.fshw.2021.11.013

Article  CAS  Google Scholar 

Ma JJ, Ma LY, Zhang H, Zhang ZQ, Wang YQ, Li K, Chen XM (2018b) Policosanol fabrication from insect wax and optimization by response surface methodology. PloS one 13. https://doi.org/10.1371/journal.pone.0197343

Malaiwong N, Chalorak P, Jattujan P, Manohong P, Niamnont N, Suphamungmee W, Sobhon P, Meemon K (2019) Anti-Parkinson activity of bioactive substances extracted from Holothuria leucospilota. Biomed Pharmacother 109:1967–1977. https://doi.org/10.1016/j.biopha.2018.11.063

Article  CAS  Google Scholar 

Mao Q, Qin WZ, Zhang A, Ye N (2020) Recent advances in dopaminergic strategies for the treatment of Parkinson’s disease. Acta Pharmacol Sin 41:471–482. https://doi.org/10.1038/s41401-020-0365-y

Article  CAS  Google Scholar 

Marques NF, Massari CM, Tasca CI (2019) Guanosine Protects Striatal Slices Against 6-OHDA-Induced Oxidative Damage, Mitochondrial Dysfunction, and ATP Depletion. Neurotox Res 35:475–483. https://doi.org/10.1007/s12640-018-9976-1

Article  CAS  Google Scholar 

Mehra S, Sahay S, Maji SK (2019) α-Synuclein misfolding and aggregation: Implications in Parkinson’s disease pathogenesis. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1867:890–908. https://doi.org/10.1016/j.bbapap.2019.03.001

Moore DJ, West AB, Dawson VL, Dawson TM (2005) Molecular pathophysiology of Parkinson’s disease. Annu Rev Neurosci 28:57–87. https://doi.org/10.1146/annurev.neuro.28.061604.135718

Article  CAS  Google Scholar 

Nasuti C, Brunori G, Eusepi P, Marinelli L, Ciccocioppo R, Gabbianelli R (2017) Early life exposure to permethrin: a progressive animal model of Parkinson’s disease. J Pharmacol Toxicol Methods 83:80–86. https://doi.org/10.1016/j.vascn.2016.10.003

Article  CAS  Google Scholar 

Neef DW, Jaeger AM, Thiele DJ (2011) Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases. Nat Rev Drug Discovery 10:930–944. https://doi.org/10.1038/nrd3453

Article  CAS  Google Scholar 

Offenburger SL, Gartner A (2018) 6-hydroxydopamine (6-OHDA) Oxidative Stress Assay for Observing Dopaminergic Neuron Loss in Caenorhabditis elegans. Bio Protoc 8. https://doi.org/10.21769/BioProtoc.3025.

Park HJ, Yadav D, Jeong DJ, Kim SJ, Bae MA, Kim JR, Cho KH (2019) Short-Term Consumption of Cuban Policosanol Lowers Aortic and Peripheral Blood Pressure and Ameliorates Serum Lipid Parameters in Healthy Korean Participants: Randomized, Double-Blinded, and Placebo-Controlled Study. Int J Environ Res Public Health 16. https://doi.org/10.3390/ijerph16050809

Pourkarimi E, Greiss S, Gartner A (2012) Evidence that CED-9/Bcl2 and CED-4/Apaf-1 localization is not consistent with the current model for C. elegans apoptosis induction. Cell Death Differ 19:406–415. https://doi.org/10.1038/cdd.2011.104

Article  CAS  Google Scholar 

Rango M, Bresolin N (2018) Brain mitochondria aging and parkinson’s disease. Genes 9(5):250. https://doi.org/10.3390/genes9050250

Rashidi R, Ghorbani A, Rakhshandeh H, Mousavi SH (2021) Protective effect of Artemisia absinthium on 6-hydroxydopamine-induced toxicity in SH-SY5Y cell line. Avicenna J Phytomed 11:238–246