Ashina M, Terwindt GM, Al-Karagholi MA-M et al (2021) Migraine: disease characterisation, biomarkers, and precision medicine. Lancet 397:1496–1504

Article  Google Scholar 

Ashina M (2020) Migraine. N Engl J Med 383:1866–1876

Article  Google Scholar 

Ashina M, Hansen JM, Do TP et al (2019) Migraine and the trigeminovascular system—40 years and counting. Lancet Neurol 18:795–804

Article  Google Scholar 

Olesen J, Burstein R, Ashina M et al (2009) Origin of pain in migraine: evidence for peripheral sensitisation. Lancet Neurol 8:679–690

Article  Google Scholar 

Ashina M, Hansen JM, Á Dunga BO et al (2017) Human models of migraine-short-Term pain for long-Term gain. Nat Rev Neurol 13:713–724

Article  Google Scholar 

Headache Classification Committee of the International Headache Society (IHS) (2018) The International Classification of Headache Disorders, 3rd edition. Cephalalgia 38(1):1–211. https://doi.org/10.1177/0333102417738202

Karsan N, Goadsby PJ (2018) Biological insights from the premonitory symptoms of migraine. Nat Rev Neurol 14:699–710

Article  Google Scholar 

Eigenbrodt AK, Christensen RH, Ashina H et al (2022) Premonitory symptoms in migraine: a systematic review and meta-analysis of observational studies reporting prevalence or relative frequency. J Headache Pain 23:140

Article  Google Scholar 

Ricci JA, Chee E, Lorandeau AL et al (2007) Fatigue in the U.S. Workforce: Prevalence and Implications for Lost Productive Work Time. J Occup Environ Med 49:1–10

Article  Google Scholar 

Lassen L, Haderslev P, Jacobsen V et al (2002) Cgrp May Play A Causative Role in Migraine. Cephalalgia 22:54–61

Article  Google Scholar 

Schytz HW, Birk S, Wienecke T et al (2009) PACAP38 induces migraine-like attacks in patients with migraine without aura. Brain 132:16–25

Article  Google Scholar 

Guo S, Vollesen ALH, Olesen J et al (2016) Premonitory and nonheadache symptoms induced by CGRP and PACAP38 in patients with migraine. Pain 157:2773–2781

Article  Google Scholar 

Schulte LH, May A (2016) The migraine generator revisited: continuous scanning of the migraine cycle over 30 days and three spontaneous attacks. Brain 139:1987–1993

Article  Google Scholar 

Derbyshire SWG, Jones AKP, Creed F et al (2002) Cerebral Responses to Noxious Thermal Stimulation in Chronic Low Back Pain Patients and Normal Controls. Neuroimage 16:158–168

Article  Google Scholar 

Hsieh J-C, Ståhle-Bäckdahl M, Hägermark Ö et al (1996) Traumatic nociceptive pain activates the hypothalamus and the periaqueductal gray: a positron emission tomography study. Pain 64:303–314

Article  Google Scholar 

Iadarola M (1998) Neural activation during acute capsaicin-evoked pain and allodynia assessed with PET. Brain 121:931–947

Article  Google Scholar 

Petrovic P, Ingvar M, Stone-Elander S et al (1999) A PET activation study of dynamic mechanical allodynia in patients with mononeuropathy. Pain 83:459–470

Article  Google Scholar 

Haas DC, Kent PF, Friedman DI (1993) Headache Caused by a Single Lesion of Multiple Sclerosis in the Periaqueductal Gray Area. Headache J Head Face Pain 33:452–454

Article  Google Scholar 

Afridi S (2003) New onset migraine with a brain stem cavernous angioma. J Neurol Neurosurg Psychiatry 74:680–681

Article  Google Scholar 

Goadsby P (2002) Neurovascular Headache and A Midbrain Vascular Malformation: Evidence for A Role of the Brainstem in Chronic Migraine. Cephalalgia 22:107–111

Article  Google Scholar 

Burstein R, Yarnitsky D, Goor-Aryeh I et al (2000) An association between migraine and cutaneous allodynia. Ann Neurol 47:614–624

Article  Google Scholar 

Lipton RB, Bigal ME, Ashina S et al (2008) Cutaneous allodynia in the migraine population. Ann Neurol 63:148–158

Article  Google Scholar 

Burstein R, Collins B, Jakubowski M (2004) Defeating migraine pain with triptans: A race against the development of cutaneous allodynia. Ann Neurol 55:19–26

Article  Google Scholar 

Pietrobon D, Moskowitz MA (2014) Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations. Nat Rev Neurosci 15:379–393

Article  Google Scholar 

Rasmussen BK, Olesen J (1992) Migraine With Aura and Migraine Without Aura: An Epidemiological Study. Cephalalgia 12:221–228

Article  Google Scholar 

Hansen JM, Lipton RB, Dodick DW et al (2012) Migraine headache is present in the aura phase: A prospective study. Neurology 79:2044–2049

Article  Google Scholar 

Olesen J, Larsen B, Lauritzen M (1981) Focal hyperemia followed by spreading oligemia and impaired activation of rcbf in classic migraine. Ann Neurol 9:344–352

Article  Google Scholar 

Hadjikhani N, Sanchez del Rio M, Wu O et al (2001) Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci 98:4687–4692

Article  Google Scholar 

Olesen J, Lauritzen M, Tfelt-Hansen P et al (1982) Spreading Cerebral Oligemia in Classical- and Normal Cerebral Blood Flow in Common Migraine. Headache J Head Face Pain 22:242–248

Article  Google Scholar 

Aiba S, Tatsumoto M, Saisu A et al (2010) Prevalence of typical migraine aura without headache in Japanese ophthalmology clinics. Cephalalgia 30:962–967

Article  Google Scholar 

Amos JF, Fleming JB (2000) Clinical description and review of migraine aura without headache. Optometry 71:372–380

Google Scholar 

Fisher CM (1986) Late-life migraine accompaniments–further experience. Stroke 17:1033–1042

Article  Google Scholar 

Wijman CAC, Wolf PA, Kase CS et al (1998) Migrainous Visual Accompaniments Are Not Rare in Late Life. Stroke 29:1539–1543

Article  Google Scholar 

Hansen JM, Hauge AW, Olesen J et al (2010) Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura. Cephalalgia 30:1179–1186

Article  Google Scholar 

Wiggers A, Ashina H, Hadjikhani N et al (2022) Brain barriers and their potential role in migraine pathophysiology. J Headache Pain 23:16

Article  Google Scholar 

Amin FM, Hougaard A, Cramer SP et al (2017) Intact blood−brain barrier during spontaneous attacks of migraine without aura: a 3T DCE-MRI study. Eur J Neurol 24:1116–1124

Article  Google Scholar 

Hougaard A, Amin FM, Christensen CE et al (2017) Increased brainstem perfusion, but no blood-brain barrier disruption, during attacks of migraine with aura. Brain 140:1633–1642

Article  Google Scholar 

Donnelly A, Sinnott B, Boyle R, et al. Beware the middle-aged migraine: internal carotid artery dissection mimicking migraine in the emergency department. BMJ Case Rep. 2017;bcr-2017–221774.

Ramadan NM, Tietjen GE, Levine SR et al (1991) Scintillating scotomata associated with internal carotid artery dissection: Report of three cases. Neurology 41:1084–1084

Article  Google Scholar 

Thomsen AV, Sørensen MT, Ashina M et al (2021) Symptomatic migraine: a systematic review to establish a clinically important diagnostic entity. Headache J Head Face Pain 61:1180–1193

Article  Google Scholar 

van den Maagdenberg AMJ, Pietrobon D, Pizzorusso T et al (2004) A cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression. Neuron 41:701–710

Article  Google Scholar 

Eikermann-Haerter K, Dileköz E, Kudo C, et al. Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1. J Clin Invest. Epub ahead of print 22 December 2008. https://doi.org/10.1172/JCI36059.

van den Maagdenberg AMJM, Pizzorusso T, Kaja S et al (2010) High cortical spreading depression susceptibility and migraine-associated symptoms in Ca v 2.1 S218L mice. Ann Neurol 67:85–98

Article  Google Scholar 

Leo L, Gherardini L, Barone V et al (2011) Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2. PLoS Genet 7:e1002129

Article  Google Scholar 

Nyholt DR, LaForge KS, Kallela M et al (2008) A high-density association screen of 155 ion transport genes for involvement with common migraine. Hum Mol Genet 17:3318–3331

Article  Google Scholar 

Kirchmann M, Thomsen LL, Olesen J (2006) The CACNA1A and ATP1A2 genes are not involved in dominantly inherited migraine with aura. Am J Med Genet Part B Neuropsychiatr Genet 141B:250–256

Article  Google Scholar 

Jen JC, Kim GW, Dudding KA et al (2004) No Mutations in CACNA1A and ATP1A2 in Probands With Common Types of Migraine. Arch Neurol 61:926

Article  Google Scholar 

Wieser T, Mueller C, Evers S, et al. Absence of Known Familial Hemiplegic Migraine (FHM) Mutations in the CACNA1A Gene in Patients with common Migraine: Implications for Genetic Testing. Clin Chem Lab Med; 41. Epub ahead of print 24 January 2003. https://doi.org/10.1515/CCLM.2003.042.

Younis S, Do TP, Ashina M (2021) Human Models. In: Maassen van den Brink, A., Martelletti P. (eds) Monoclonal Antibodies in Headache . Headache. Springer, Cham. https://doi.org/10.1007/978-3-030-69032-8_5

Ghanizada H, Al-Karagholi MA-M, Arngrim N et al (2020) PACAP27 induces migraine-like attacks in migraine patients. Cephalalgia 40:57–67

Article  Google Scholar 

Amin FM, Hougaard A, Schytz HW et al (2014) Investigation of the pathophysiological mechanisms of migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38. Brain 137:779–794

Article  Google Scholar 

Pecile A, Guidobono F, Netti C et al (1987) Calcitonin gene-related peptide: antinociceptive activity in rats, comparison with calcitonin. Regul Pept 18:189–199

Article  Google Scholar 

Candeletti S, Ferri S (1990) Antinociceptive profile of intracerebroventricular salmon calcitonin and calcitonin gene-related peptide in the mouse formalin test. Neuropeptides 17:93–98

Article  Google Scholar 

Zhang YZ, Sjőlund B, Moller K et al (1993) Pituitary adenylate cyclase activating peptide produces a marked and long-lasting depression of a C-fibre-evoked flexion reflex. Neuroscience 57:733–737

Article  Google Scholar 

Yamamoto T, Tatsuno I (1995) Antinociceptive effect of intrathecally administered pituitary adenylate cyclase activating polypeptide (PACAP) on the rat formalin test. Neurosci Lett 184:32–35

Article  Google Scholar 

Fontaine D, Almairac F, Santucci S et al (2018) Dural and pial pain-sensitive structures in humans: new inputs from awake craniotomies. Brain 141:1040–1048

Article  Google Scholar 

Al-Karagholi MA-M, Ghanizada H, Nielsen CAW, et al. Opening of ATP sensitive potassium channels causes migraine attacks with aura. Brain. Epub ahead of print March 2021. https://doi.org/10.1093/brain/awab136.