Nikolich-Zugich J. The twilight of immunity: emerging concepts in aging of the immune system. Nat Immunol. 2018;19:10–9. https://doi.org/10.1038/s41590-017-0006-x.
Albright JF, Albright JW. Aging, immunity, and infection. Humana Press. 2003, Totowa, NJ, USA.
DeSantis CE, et al. Cancer statistics for adults aged 85 years and older, 2019. CA Cancer J Clin. 2019;69:452–67. https://doi.org/10.3322/caac.21577.
Helissey C, Vicier C, Champiat S. The development of immunotherapy in older adults: new treatments, new toxicities? J Geriatr Oncol. 2016;7:325–33. https://doi.org/10.1016/j.jgo.2016.05.007.
Nishijima TF, Muss HB, Shachar SS, Moschos SJ. Comparison of efficacy of immune checkpoint inhibitors (ICIs) between younger and older patients: a systematic review and meta-analysis. Cancer Treat Rev. 2016;45:30–7. https://doi.org/10.1016/j.ctrv.2016.02.006.
Seluanov A, Gladyshev VN, Vijg J, Gorbunova V. Mechanisms of cancer resistance in long-lived mammals. Nat Rev Cancer. 2018;18:433–41. https://doi.org/10.1038/s41568-018-0004-9.
Krenzien F, et al. A rationale for age-adapted immunosuppression in organ transplantation. Transplant. 2015;99:2258–68. https://doi.org/10.1097/TP.0000000000000842.
van den Bosch TP, Kannegieter NM, Hesselink DA, Baan CC, Rowshani AT. Targeting the monocyte-macrophage lineage in solid organ transplantation. Front Immunol. 2017;8:153. https://doi.org/10.3389/fimmu.2017.00153.
Roh JS, Sohn DH. Damage-associated molecular patterns in inflammatory diseases. Immune Netw. 2018;18:e27. https://doi.org/10.4110/in.2018.18.e27.
Boehmer ED, Goral J, Faunce DE, Kovacs EJ. Age-dependent decrease in toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. J Leukoc Biol. 2004;75:342–9. https://doi.org/10.1189/jlb.0803389.
Boehmer ED, Meehan MJ, Cutro BT, Kovacs EJ. Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway. Mech Ageing Dev. 2005;126:1305–13. https://doi.org/10.1016/j.mad.2005.07.009.
Metcalf TU, et al. Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors. Aging Cell. 2015;14:421–32. https://doi.org/10.1111/acel.12320.
Park SB, Kim JK, Cho KS. Complications of renal transplantation: ultrasonographic evaluation. J Ultrasound Med. 2007;26:615–33. https://doi.org/10.7863/jum.2007.26.5.615.
Granata, S. et al. Oxidative stress and ischemia/reperfusion injury in kidney transplantation: focus on ferroptosis, mitophagy and new antioxidants. Antioxidants (Basel) 2022;11. https://doi.org/10.3390/antiox11040769.
Liguori I, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018;13:757–72. https://doi.org/10.2147/CIA.S158513.
Zhang Z, et al. A clinically relevant murine model unmasks a “two-hit” mechanism for reactivation and dissemination of cytomegalovirus after kidney transplant. Am J Transplant. 2019;19:2421–33. https://doi.org/10.1111/ajt.15376.
Conde P, et al. DC-SIGN(+) Macrophages control the induction of transplantation tolerance. Immunity. 2015;42:1143–58. https://doi.org/10.1016/j.immuni.2015.05.009.
Duong L, et al. Macrophage function in the elderly and impact on injury repair and cancer. Immun Ageing. 2021;18:4. https://doi.org/10.1186/s12979-021-00215-2.
Agrawal A, Agrawal S, Tay J, Gupta S. Biology of dendritic cells in aging. J Clin Immunol. 2008;28:14–20. https://doi.org/10.1007/s10875-007-9127-6.
Agrawal A, Gupta S. Impact of aging on dendritic cell functions in humans. Ageing Res Rev. 2011;10:336–45. https://doi.org/10.1016/j.arr.2010.06.004.
Varas A, et al. Age-dependent changes in thymic macrophages and dendritic cells. Microsc Res Tech. 2003;62:501–7. https://doi.org/10.1002/jemt.10411.
Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol. 2003;21:685–711. https://doi.org/10.1146/annurev.immunol.21.120601.141040.
Ordemann R, et al. Enhanced allostimulatory activity of host antigen-presenting cells in old mice intensifies acute graft-versus-host disease. J Clin Invest. 2002;109:1249–56. https://doi.org/10.1172/JCI14793.
Reynoso ED, Lee JW, Turley SJ. Peripheral tolerance induction by lymph node stroma. Adv Exp Med Biol. 2009;633:113–27. https://doi.org/10.1007/978-0-387-79311-5_10.
Onder L, Ludewig B. A fresh view on lymph node organogenesis. Trends Immunol. 2018;39:775–87. https://doi.org/10.1016/j.it.2018.08.003.
Brown FD, Turley SJ. Fibroblastic reticular cells: organization and regulation of the T lymphocyte life cycle. J Immunol. 2015;194:1389–94. https://doi.org/10.4049/jimmunol.1402520.
Link A, et al. Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat Immunol. 2007;8:1255–65. https://doi.org/10.1038/ni1513.
Alexandre YO, Mueller SN. Stromal cell networks coordinate immune response generation and maintenance. Immunol Rev. 2018;283:77–85. https://doi.org/10.1111/imr.12641.
Bromley SK, Thomas SY, Luster AD. Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics. Nat Immunol. 2005;6:895–901. https://doi.org/10.1038/ni1240.
Grasso C, Pierie C, Mebius RE, van Baarsen LGM. Lymph node stromal cells: subsets and functions in health and disease. Trends Immunol. 2021;42:920–36. https://doi.org/10.1016/j.it.2021.08.009.
Krishnamurty AT, Turley SJ. Lymph node stromal cells: cartographers of the immune system. Nat Immunol. 2020;21:369–80. https://doi.org/10.1038/s41590-020-0635-3.
Thompson HL, et al. Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates. Aging Cell. 2019;18:e12865. https://doi.org/10.1111/acel.12865.
Becklund BR, et al. The aged lymphoid tissue environment fails to support naive T cell homeostasis. Sci Rep. 2016;6:30842. https://doi.org/10.1038/srep30842.
Richner JM, et al. Age-dependent cell trafficking defects in draining lymph nodes impair adaptive immunity and control of West Nile virus infection. PLoS Pathog. 2015;11:e1005027. https://doi.org/10.1371/journal.ppat.1005027.
Kwok TMS, Silva-Junior IA, Brown EM, Haug JC, Barrios MR, Morris KA and Lancaster JN. Age-associated changes to lymph node fibroblastic reticular cells. Frontiers in Aging 2022;838943. https://doi.org/10.3389/fragi.2022.838943.
Sonar SA, Uhrlaub JL, Coplen CP, Sempowski GD, Dudakov JA, van den Brink MRM, LaFleur BJ, Jergovic M, Nikolich-Zugich J. Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging. PNAS USA 2022:119(17);e202108119. https://doi.org/10.1073/pnas.2121028119
Cohen JN, et al. Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation. J Exp Med. 2010;207:681–8. https://doi.org/10.1084/jem.20092465.
Fletcher AL, Acton SE, Knoblich K. Lymph node fibroblastic reticular cells in health and disease. Nat Rev Immunol. 2015;15:350–61. https://doi.org/10.1038/nri3846.
Yip L, et al. Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes. Nat Immunol. 2009;10:1026–33. https://doi.org/10.1038/ni.1773.
Fletcher AL, et al. Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions. J Exp Med. 2010;207:689–97. https://doi.org/10.1084/jem.20092642.
Lee JW, et al. Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nat Immunol. 2007;8:181–90. https://doi.org/10.1038/ni1427.
Dubrot J, et al. Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4(+) T cell tolerance. J Exp Med. 2014;211:1153–66. https://doi.org/10.1084/jem.20132000.
Kedl RM, et al. Migratory dendritic cells acquire and present lymphatic endothelial cell-archived antigens during lymph node contraction. Nat Commun. 2017;8:2034. https://doi.org/10.1038/s41467-017-02247-z.
Saxena V, et al. Role of lymph node stroma and microenvironment in T cell tolerance. Immunol Rev. 2019;292:9–23. https://doi.org/10.1111/imr.12799.
Li L, Wu J, Abdi R, Jewell CM, Bromberg JS. Lymph node fibroblastic reticular cells steer immune responses. Trends Immunol. 2021;42:723–34. https://doi.org/10.1016/j.it.2021.06.006.
Baptista AP et al. Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation. Elife 2014;3. https://doi.org/10.7554/eLife.04433.
Nakayama Y, Bromberg JS. Lymphotoxin-beta receptor blockade induces inflammation and fibrosis in tolerized cardiac allografts. Am J Transplant. 2012;12:2322–34. https://doi.org/10.1111/j.1600-6143.2012.04090.x.
Kokkonen TS, Augustin MT, Makinen JM, Kokkonen J, Karttunen TJ. High endothelial venules of the lymph nodes express Fas ligand. J Histochem Cytochem. 2004;52:693–9. https://doi.org/10.1177/002215540405200513.
Liu X, et al. Tolerance induction towards cardiac allografts under costimulation blockade is impaired in CCR7-deficient animals but can be restored by adoptive transfer of syngeneic plasmacytoid dendritic cells. Eur J Immunol. 2011;41:611–23. https://doi.org/10.1002/eji.201040877.
Simon T, et al. Differential regulation of T-cell immunity and tolerance by stromal laminin expressed in the lymph node. Transplant. 2019;103:2075–89. https://doi.org/10.1097/TP.0000000000002774.
Li L, et al. The lymph node stromal laminin alpha5 shapes alloimmunity. J Clin Invest. 2020;130:2602–19. https://doi.org/10.1172/JCI135099.
Li, L. et al. Lymph node fibroblastic reticular cells preserve a tolerogenic niche in allograft transplantation through laminin alpha4. J Clin Invest 2022;132. https://doi.org/10.1172/JCI156994
Nakayama Y, Brinkman CC, Bromberg JS. Murine fibroblastic reticular cells from lymph node interact with CD4+ T cells through CD40-CD40L. Transplant. 2015;99:1561–7. https://doi.org/10.1097/TP.0000000000000710.
Burrell BE, et al. Lymph node stromal fiber ER-TR7 modulates CD4+ T cell lymph node trafficking and transplant tolerance. Transplant. 2015;99:1119–25. https://doi.org/10.1097/TP.0000000000000664.
Masters AR, Jellison ER, Puddington L, Khanna KM, Haynes L. Attrition of T cell zone fibroblastic reticular cell number and function in aged spleens. Immunohorizons. 2018;2:155–63. https://doi.org/10.4049/immunohorizons.1700062.
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