*Department of Physiology, Hebei Medical University, Shijiazhuang, China;

†Department of Pharmacology, School of Basic Medical Sciences, Hebei University, Baoding, China;

‡Hebei Collaborative Innovation Center for Cardio-cerebrovascular Disease, Shijiazhuang, China; and

§Department of Pediatrics, The Second Affiliated Hospital, Hebei Medical University, Shijiazhuang, China.

Correspondence: Xiaoning Wang, Heping West Road No. 215, Shijiazhuang 050000, China (e-mail: [email protected]) or Xu Teng, Zhongshan East Road No. 361, Shijiazhuang, China 050017 (e mail: [email protected]).

This work is funded by the National Natural Science Foundation of China (81100229, 81770499, 21605035) and the Natural Science Foundation of Hebei [CN] (H2016206264, H2020206350, H2013201203).

The authors report no conflicts of interest.

J. Sheng and W. Yipu contributed equally to this work.