Hypoxia and TNF-α Synergistically Induce Expression of IL-6 and IL-8 in Human Fibroblast-like Synoviocytes via Enhancing TAK1/NF-κB/HIF-1α Signaling

Korb-Pap, A., J. Bertrand, J. Sherwood, and T. Pap. 2016. Stable activation of fibroblasts in rheumatic arthritis - causes and consequences. Rheumatology 55: 64–67.

Article  Google Scholar 

Huber, L.C., O. Distler, I. Tarner, R.E. Gay, S. Gay, and T. Pap. 2006. Synovial fibroblasts: Key players in rheumatoid arthritis. Rheumatology (Oxford) 45: 669–675.

Article  CAS  Google Scholar 

Yokota, K., T. Miyazaki, M. Hirano, Y. Akiyama, and T. Mimura. 2006. Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Journal of Rheumatology 33: 463–471.

CAS  Google Scholar 

Luo, X.J., X.R. Mo, and L.L. Zhou. 2012. The effect of Hsp72 on IL-6, IL-8 expression and activation of NF-kappaB in synoviocytes of rheumatoid arthritis. Zhongguo Ying Yong Sheng Li Xue Za Zhi 28: 336–339.

CAS  Google Scholar 

Li, Y., and W. Zhang. 2017. IL-6: The next key target for rheumatoid arthritis after TNF-alpha. Sheng Wu Gong Cheng Xue Bao 33: 36–43.

Google Scholar 

Quinonez-Flores, C.M., S.A. Gonzalez-Chavez, and C. Pacheco-Tena. 2016. Hypoxia and its implications in rheumatoid arthritis. Journal of Biomedical Science 23: 62.

Article  Google Scholar 

Fearon, U., M. Canavan, M. Biniecka, and D.J. Veale. 2016. Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis. Nature Reviews Rheumatology 12: 385–397.

Article  CAS  Google Scholar 

Muz, B., M.N. Khan, S. Kiriakidis, and E.M. Paleolog. 2009. Hypoxia The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis. Arthritis Research & Therapy 11: 201.

Article  Google Scholar 

Niu, X., Y. Chen, L. Qi, G. Liang, Y. Wang, L. Zhang, Y. Qu, and W. Wang. 2019. Hypoxia regulates angeogenic-osteogenic coupling process via up-regulating IL-6 and IL-8 in human osteoblastic cells through hypoxia-inducible factor-1alpha pathway. Cytokine 113: 117–127.

Article  CAS  Google Scholar 

D’Ignazio, L., and S. Rocha. 2016. Hypoxia induced NF-kappaB. Cells 5: 10.

Google Scholar 

Deng, W., X. Feng, X. Li, D. Wang, and L. Sun. 2016. Hypoxia-inducible factor 1 in autoimmune diseases. Cellular Immunology 303: 7–15.

Article  CAS  Google Scholar 

Guan, S.Y., R.X. Leng, J.H. Tao, X.P. Li, D.Q. Ye, N. Olsen, S.G. Zheng, and H.F. Pan. 2017. Hypoxia-inducible factor-1alpha: A promising therapeutic target for autoimmune diseases. Expert Opinion on Therapeutic Targets 21: 715–723.

Article  CAS  Google Scholar 

Guo, X., and G. Chen. 2020. Hypoxia-inducible factor is critical for pathogenesis and regulation of immune cell functions in rheumatoid arthritis. Frontiers in Immunology 11: 1668.

Article  CAS  Google Scholar 

Ryu, J.H., C.S. Chae, J.S. Kwak, H. Oh, Y. Shin, Y.H. Huh, C.G. Lee, Y.W. Park, C.H. Chun, Y.M. Kim, S.H. Im, and J.S. Chun. 2014. Hypoxia-inducible factor-2alpha is an essential catabolic regulator of inflammatory rheumatoid arthritis. PLoS Biology 12: e1001881.

Article  Google Scholar 

Nonomura, Y., F. Mizoguchi, A. Suzuki, T. Nanki, H. Kato, N. Miyasaka, and H. Kohsaka. 2009. Hypoxia-induced abrogation of contact-dependent inhibition of rheumatoid arthritis synovial fibroblast proliferation. Journal of Rheumatology 36: 698–705.

Article  CAS  Google Scholar 

Sabi, E.M., A. Singh, Z.M. Althafar, T. Behl, A. Sehgal, S. Singh, N. Sharma, S. Bhatia, A. Al-Harrasi, H.M. Alqahtani, and S. Bungau. 2022. Elucidating the role of hypoxia-inducible factor in rheumatoid arthritis. Inflammopharmacology 30: 737–748.

Article  CAS  Google Scholar 

Malkov, M.I., C.T. Lee, and C.T. Taylor. 2021. Regulation of the hypoxia-inducible factor (HIF) by pro-inflammatory cytokines. Cells 10: 2340.

Article  CAS  Google Scholar 

Thornton, R.D., P. Lane, R.C. Borghaei, E.A. Pease, J. Caro, and E. Mochan. 2000. Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts. The Biochemical Journal 350 (Pt 1): 307–312.

Article  CAS  Google Scholar 

Hellwig-Burgel, T., K. Rutkowski, E. Metzen, J. Fandrey, and W. Jelkmann. 1999. Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1. Blood 94: 1561–1567.

Article  CAS  Google Scholar 

Westra, J., E. Brouwer, R. Bos, M.D. Posthumus, B. Doornbos-van der Meer, C.G. Kallenberg, and P.C. Limburg. 2007. Regulation of cytokine-induced HIF-1alpha expression in rheumatoid synovial fibroblasts. Annals of the New York Academy of Sciences 1108: 340–348.

Article  CAS  Google Scholar 

Georganas, C., H. Liu, H. Perlman, A. Hoffmann, B. Thimmapaya, and R.M. Pope. 2000. Regulation of IL-6 and IL-8 expression in rheumatoid arthritis synovial fibroblasts: The dominant role for NF-kappa B but not C/EBP beta or c-Jun. The Journal of Immunology 165: 7199–7206.

Article  CAS  Google Scholar 

Luo, X., X. Zuo, Y. Zhou, B. Zhang, Y. Shi, M. Liu, K. Wang, D.R. McMillian, and X. Xiao. 2008. Extracellular heat shock protein 70 inhibits tumour necrosis factor-alpha induced proinflammatory mediator production in fibroblast-like synoviocytes. Arthritis Research & Therapy 10: R41.

Article  Google Scholar 

Mo, X.R., J.W. Xie, G.J. Lv, Y.P. Ke, and X.J. Luo. 2017. Effects of TAK gene silencing on the expressions of IL-6 and IL-8 induced by TNF-alpha in fibroblast-like synoviocytes. Zhongguo Ying Yong Sheng Li Xue Za Zhi 33: 471–475.

Google Scholar 

Zhang, J., F.F. Gao, and J. Xie. 2021. LncRNA linc00152/NF-kappaB feedback loop promotes fibroblast-like synovial cells inflammation in rheumatoid arthritis via regulating miR-103a/TAK1 axis and YY1 expression. Immun Inflamm Dis 9: 681–693.

Article  CAS  Google Scholar 

Li, G., Y. Zhang, Y. Qian, H. Zhang, S. Guo, M. Sunagawa, T. Hisamitsu, and Y. Liu. 2013. Interleukin-17A promotes rheumatoid arthritis synoviocytes migration and invasion under hypoxia by increasing MMP2 and MMP9 expression through NF-kappaB/HIF-1alpha pathway. Molecular Immunology 53: 227–236.

Article  CAS  Google Scholar 

Hui, W., C. Zhao, and S.G. Bourgoin. 2017. Differential effects of inhibitor combinations on lysophosphatidic acid-mediated chemokine secretion in unprimed and tumor necrosis factor-alpha-primed synovial fibroblasts. Frontiers in Pharmacology 8: 848.

Article  Google Scholar 

Fabre, C., G. Carvalho, E. Tasdemir, T. Braun, L. Ades, J. Grosjean, S. Boehrer, D. Metivier, S. Souquere, G. Pierron, P. Fenaux, and G. Kroemer. 2007. NF-kappaB inhibition sensitizes to starvation-induced cell death in high-risk myelodysplastic syndrome and acute myeloid leukemia. Oncogene 26: 4071–4083.

Article  CAS  Google Scholar 

Taylor, C.T., and E.P. Cummins. 2009. The role of NF-kappaB in hypoxia-induced gene expression. Annals of the New York Academy of Sciences 1177: 178–184.

Article  CAS  Google Scholar 

Maxwell, P.J., R. Gallagher, A. Seaton, C. Wilson, P. Scullin, J. Pettigrew, I.J. Stratford, K.J. Williams, P.G. Johnston, and D.J. Waugh. 2007. HIF-1 and NF-kappaB-mediated upregulation of CXCR1 and CXCR2 expression promotes cell survival in hypoxic prostate cancer cells. Oncogene 26: 7333–7345.

Article  CAS  Google Scholar 

Akimoto, R., T. Tanaka, T. Nakano, Y. Hozumi, K. Kawamae, and K. Goto. 2020. DGKzeta depletion attenuates HIF-1alpha induction and SIRT1 expression, but enhances TAK1-mediated AMPKalpha phosphorylation under hypoxia. Cellular Signalling 71: 109618.

Article  CAS  Google Scholar 

Lee, Y.A., H.M. Choi, S.H. Lee, S.J. Hong, H.I. Yang, M.C. Yoo, and K.S. Kim. 2012. Hypoxia differentially affects IL-1beta-stimulated MMP-1 and MMP-13 expression of fibroblast-like synoviocytes in an HIF-1alpha-dependent manner. Rheumatology (Oxford) 51: 443–450.

Article  CAS  Google Scholar 

Ahn, J.K., E.M. Koh, H.S. Cha, Y.S. Lee, J. Kim, E.K. Bae, and K.S. Ahn. 2008. Role of hypoxia-inducible factor-1alpha in hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes. Rheumatology (Oxford) 47: 834–839.

Article  CAS  Google Scholar 

Charbonneau, M., K. Harper, F. Grondin, M. Pelmus, P.P. McDonald, and C.M. Dubois. 2007. Hypoxia-inducible factor mediates hypoxic and tumor necrosis factor alpha-induced increases in tumor necrosis factor-alpha converting enzyme/ADAM17 expression by synovial cells. Journal of Biological Chemistry 282: 33714–33724.

Article  CAS  Google Scholar 

Islam, S.M.T., J. Won, M. Khan, M.D. Mannie, and I. Singh. 2021. Hypoxia-inducible factor-1 drives divergent immunomodulatory functions in the pathogenesis of autoimmune diseases. Immunology 164: 31–42.

Article  CAS  Google Scholar 

Taylor, C.T., G. Doherty, P.G. Fallon, and E.P. Cummins. 2016. Hypoxia-dependent regulation of inflammatory pathways in immune cells. The Journal of Clinical Investigation 126: 3716–3724.

Article  Google Scholar 

Li, X., H. Kimura, K. Hirota, K. Kasuno, K. Torii, T. Okada, H. Kurooka, Y. Yokota, and H. Yoshida. 2005. Synergistic effect of hypoxia and TNF-alpha on production of PAI-1 in human proximal renal tubular cells. Kidney International 68: 569–583.

Article  CAS  Google Scholar 

Lee, S.H., Y.J. Lee, and H.J. Han. 2010. Effect of arachidonic acid on hypoxia-induced IL-6 production in mouse ES cells: Involvement of MAPKs, NF-kappaB, and HIF-1alpha. Journal of Cellular Physiology 222: 574–585.

CAS  Google Scholar 

Cetin, A., T. Kaya, N. Demirkoprulu, B. Karadas, B. Duran, and M. Cetin. 2004. YC-1, a nitric oxide-independent activator of soluble guanylate cyclase, inhibits the spontaneous contractions of isolated pregnant rat myometrium. Journal of Pharmacological Sciences 94: 19–24.

Article  CAS  Google Scholar 

Flores-Costa, R., J. Alcaraz-Quiles, E. Titos, C. Lopez-Vicario, M. Casulleras, M. Duran-Guell, B. Rius, A. Diaz, K. Hall, C. Shea, R. Sarno, M. Currie, J.L. Masferrer, and J. Claria. 2018. The soluble guanylate cyclase stimulator IW-1973 prevents inflammation and fibrosis in experimental non-alcoholic steatohepatitis. British Journal of Pharmacology 175: 953–967.

Article  CAS  Google Scholar 

Rius, J., M. Guma, C. Schachtrup, K. Akassoglou, A.S. Zinkernagel, V. Nizet, R.S. Johnson, G.G. Haddad, and M. Karin. 2008. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature 453: 807–811.

Article  CAS  Google Scholar 

Culver, C., A. Sundqvist, S. Mudie, A. Melvin, D. Xirodimas, and S. Rocha. 2010. Mechanism of hypoxia-induced NF-kappaB. Molecular and Cellular Biology 30: 4901–4921.

Article  CAS  Google Scholar 

Lian, L.H., Q. Jin, S.Z. Song, Y.L. Wu, T. Bai, S. Jiang, Q. Li, N. Yang, and J.X. Nan. 2013. Ginsenoside Rh2 downregulates LPS-induced NF- kappa B activation through inhibition of TAK1 phosphorylation in RAW 264.7 murine macrophage. Evidence-Based Complementary and Alternative Medicine 2013: 646728.

Article  Google Scholar 

Zhou, Y., T. Tao, G. Liu, X. Gao, Y. Gao, Z. Zhuang, Y. Lu, H. Wang, W. Li, L. Wu, D. Zhang, and C. Hang. 2021. TRAF3 mediates neuronal apoptosis in early brain injury following subarachnoid hemorrhage via targeting TAK1-dependent MAPKs and NF-kappaB pathways. Cell Death & Disease 12: 10.

留言 (0)

沒有登入
gif