Hida E.a· Muroi K.a· Kakushima N.a,b· Furune S.a· Ishikawa E.a· Mizutani Y.a· Sawada T.a· Keiko M.a· Yamamura T.a· Ishikawa T.a· Furukawa K.a· Ohno E.a· Nakamura M.a· Nishida K.c· Fujishiro M.a,b· Kawashima H.a

Author affiliations

aDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
bDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
cBiostatistics and Bioinformatics Section, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan

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Article / Publication Details

First-Page Preview

Received: June 10, 2022
Accepted: November 11, 2022
Published online: January 05, 2023

Number of Print Pages: 10
Number of Figures: 2
Number of Tables: 6

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: https://www.karger.com/DIG

Abstract

Introduction: Eosinophils in the esophageal epithelium are unevenly distributed in eosinophilic esophagitis (EoE). Esophageal eosinophilia (EE) may be observable by endocytoscopy (EC). This study aimed to evaluate the diagnostic performance of EC for the diagnosis of EE. Methods: A total of 33 EoE patients underwent EC with methylene blue staining from March 2020 to April 2021. A total of 194 EC images with corresponding biopsies were obtained. Three findings of EC, increased squamous cells (item I), increased inflammatory cells (item II), and cells with bilobed nuclei (item III), were established. These findings were reviewed by two endoscopists to diagnose EE. Another four endoscopists reviewed the images for interobserver agreement. Results: When all three items were met by EC, the sensitivity and the accuracy for the diagnosis of EE were 88% and 76%, respectively. The integrated diagnostic odds ratios (ORs) for the diagnosis of EE of the four endoscopists were significant (OR: 3.98, 95% CI: 2.94–5.40, p < 0.001). The results were similar when only item III was met. Interobserver agreement was good for item III to diagnose EE (kappa value = 0.653). Discussion/Conclusion: The diagnostic performance of EC for EE is acceptable and has good interobserver agreement. It may be useful for targeted biopsy in EoE patients.

© 2023 S. Karger AG, Basel

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First-Page Preview

Received: June 10, 2022
Accepted: November 11, 2022
Published online: January 05, 2023

Number of Print Pages: 10
Number of Figures: 2
Number of Tables: 6

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: https://www.karger.com/DIG

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