Clusters of facilitatory and inhibitory conditioned pain modulation responses in a large sample of children, adolescents, and young adults with chronic pain

1. Introduction

Chronic pain affects about 11% to 38% of youth.18 Using psychophysical procedures, pediatric studies have shown that chronic pain is associated with altered excitatory and inhibitory endogenous pain modulation systems.2,7,8,16,17,22,23,38,40,50 The endogenous inhibitory pathways of pain modulation can be indirectly assessed using a conditioned pain modulation (CPM) paradigm using the concept of “pain inhibits pain,” in which one painful stimulus, the conditioning stimulus (CS), modulates another pain-inducing stimulus, the test stimulus (TS).17,26 Studies have observed a lower capacity to inhibit the post-conditioned painful TS in patients with chronic pain conditions when compared with age-matched control subjects.16,22,29,40,52 The endogenous facilitatory pain modulation mainly assessed using a temporal summation paradigm have been shown to be involved in some chronic pain conditions.2,6,8,38,39,50 Temporal summation of pain (TSP) is referred to as an amplification of pain perception in response to repeated or continuous painful stimulation, at a constant intensity, which indirectly reflect an increased excitability at the spinal level and receptive fields of the nociceptive spinal cord neurons.34 Evaluating temporal summation will help understand the endogenous facilitatory pain mechanisms (eg, central sensitization) in youth and its role in chronic pain conditions.

Considering the role of endogenous facilitatory and inhibitory pain responses such as CPM and TSP, and the heterogeneity within the different populations, it is important to take both into consideration in a single experimental model to give as much information as possible on subgroups of patients that may benefit from a specific therapeutic treatment.53 Researchers and clinicians have turned to identify distinct subgroups of pediatric chronic pain patients that may be relevant for treatment because individuals respond differently to standardized treatments.35,37,49,50 However, these studies strictly investigated pain and psychosocial characteristics in their analysis and there is limited data evaluating subgroups based on the endogenous pain mechanisms of pediatric chronic pain patients. Our group has shown the heterogeneity of CPM efficiency and temporal summation in samples of patients with chronic musculoskeletal pain.12,27,28,40 However, the pain modulation responses were considered separately and no association between facilitatory and inhibitory pain modulation responses were investigated or observed.

Therefore, the objective of this study was to identify subgroups in a large population of pediatric patients with chronic pain based on their endogenous facilitatory and inhibitory pain modulation responses. We conducted an exploratory analysis investigating interrelationships between individuals regarding their CPM efficiency and TSP from one CPM experimental design.

2. Methods 2.1. Participants

This study regrouped multiple studies whose ethics approval were all obtained before the beginning of the recruitment from the McGill University and McGill University Health Centre Research Ethics Boards (A08-M71-14B, A11-M62-15B, A09-M17-17B, 2019-4887, see Supplementary Table 1 for more details on sample, available at https://links.lww.com/PR9/A172). This has facilitated analysis of a large and novel cohort for investigation unlike our previously published work.12,27,28,40 Between 2015 and 2021, patients were recruited in the spine or orthopedic outpatient clinics of the Shriners Hospitals for Children—Canada or by referral from the Chronic Pain Clinic from the Montreal Children's Hospital. Age-matched control subjects with no chronic pain were recruited between 2018 and 2021 through word of mouth, advertisements, and a collaborative high school nearby. Signed informed consent was obtained from participants over 14 years old and parents of participants aged 13 years and younger. To ensure appropriate comparison across the different studies, appropriate inclusion or exclusion criteria for the patients included in the analysis were established. Inclusion criteria for patients were male or female between 8 and 21 years old, reporting chronic primary or secondary pain (at least once a week for more than 3 months). Participants who did not speak English or French or had developmental delay or substantial functional limitations that would interfere with completing measures were excluded from the study.

2.2. Conditioned pain modulation assessment 2.2.1. Pain perception

Pain before the assessment was measured verbally using a numerical rating scale (NRS) ranging from 0 (no pain) to 10 (worst pain imaginable). Pain perception during the heat pain procedure was assessed using a computerized visual analogue scale (CoVAS), ranging from 0 (no pain) to 100 (worst pain imaginable), linked to a 9-cm2 warm calibrated thermode connected to a Q-sense apparatus (Medoc, Israel). Pain perception during the cold pain procedure was assessed verbally using the NRS of 0 to 10.

2.2.2. Pretest

Conditioned pain modulation assessment was conducted using a protocol as previously described by our group.12,27,28,40 Tests were conducted by research assistants, who were trained and evaluated by the principal investigator of the study, following rigorous standards of procedure to decrease between-tester variability. The thermode with a baseline of 32°C and a 0.3°C/s upslope was applied 3 times. Participants were given the CoVAS and advised to move the cursor towards the “100” mark when they first report pain (pain threshold) and that the cursor had to be at the “100” mark when the pain was intolerable. The mean temperature at which they rated their pain intensity at 50/100 with the CoVAS was calculated.

2.2.3. Test stimulus

The thermode was applied to the right forearm to reach a predetermined test temperature to a pain intensity 50/100 (T50) and it remained constant for 120 seconds. Participants were told to evaluate their pain with the COVAS throughout the test. The average pain intensity during the 120 seconds was calculated.

2.2.4. Conditioning stimulus

A cold-pressor task (CPT) was used as the CS involving the immersion of their left forearm in a bath filled with cold water (12°C) for 120 seconds. Every 15 seconds, the participants verbally reported their pain intensity using the NRS of 0 to 10. The average pain intensity during the CS was then calculated. If pain was intolerable, participants could remove their arm before the end of the 120 seconds, and an average pain intensity score of 10/10 was given.

2.3. Assessment of inhibitory pain response

To evaluate the endogenous inhibitory pain response (CPM efficiency), the CPT was immediately followed by a second tonic heat TS with the same predetermined test temperature. Pain modulation was measured as the percentage difference in average pain intensity of the test stimuli54: 100% × (CoVASafter − CoVASbefore)/CoVASbefore. A CPM efficiency between −100% and −30% was considered optimal, between −30% and −10% as suboptimal, and between −10% and +100% as inefficient. A 30% reduction in pain intensity was labelled to be a clinically important difference11 and is approximately the mean value of inhibitory CPM observed in previous studies.12,32,40,42

2.4. Assessment of facilitatory pain response

Facilitatory pain response (TSP) was assessed as the absolute difference in pain intensity during the last 60 seconds of each TS (temporal summation phase).42 An increase or decrease in pain intensity was determined clinically significant if the change was equal to or larger than 20/100 during the temporal summation phase.11,45

2.5. Statistical analysis

Statistical analyses were performed using the R Studio software. Data were assessed for normality and descriptive statistics were conducted to describe the sample and presented as mean ± SD, unless indicated otherwise. One-way analysis of variance (ANOVA) was conducted to determine differences in CPM assessment outcomes between gender, duration of chronic pain, presence of more than one pain site, and presence of pain before CPM assessment. Spearman correlation was conducted to determine whether age, pain before the assessment, and T50 were associated with the CPM assessment outcomes. Differences between patients and control subjects were determined using the χ2 test and one-way ANOVA controlling for gender because of gender differences observed in heat pain threshold (Supplementary Table 1, available at https://links.lww.com/PR9/A172), followed by the Scheffé test. The effect size (ω2) for significant ANOVA models was also calculated (small = 0.01; medium = 0.06; and large = 0.14). Clusters within the chronic pain sample were identified using an unsupervised clustering method performed using the FactoMineR package.19 To investigate the facilitatory and inhibitory pain modulation responses, the cluster analysis involved 4 quantitative indicator variables: (1) the absolute change in pain intensity during the last 60 seconds of the first TS (TS1); (2) the average pain intensity during the CS; (3) the absolute change in pain intensity during the last 60 seconds of the second TS (TS2); and (4) the CPM efficiency. Because of the different scales and units for each variable, hierarchical clustering with k-means consolidation was conducted on the 4 variables standardized into z-scores to ensure that all variables were considered equally. The best partition of clusters was the one with the highest relative loss of inertia15 and based on parsimony.

To determine cluster effect of the indicator variables, an ANOVA model was conducted along with a Fisher test. Differences between clusters and control subjects were conducted using the χ2 test and one-way ANOVA controlling for gender followed by Scheffé test.

3. Results

Six hundred thirty-nine patients and 60 control subjects consented. However, only 608 patients were included in the analysis (n = 31 did not complete the CPM assessment or had missing information from the CPM assessment). The mean age for patients was 15.18 ± 2.14 years (range = 8.2–21.4 years) and 80.92% were females. The mean age for control subjects was 15.06 ± 2.23 years (range = 10.0–18.9 years) and 48.33% were females. Most of the patients experienced persistent pain (n = 329) than recurrent pain (n = 223) for more than 6 months (n = 568) and primarily in their back (n = 410). The primary location of pain of the other patients included the head or neck (n = 31), the abdomen (n = 24), the groin area (n = 1), the thorax (n = 14), the upper extremities (n = 18), and the lower extremities (n = 109). Moreover, 50.99% of the patients reported more than one pain site. Before the assessment, 70.23% of the patients reported pain with a mean pain intensity of 4.16 ± 2.16. Overall, patients reported a mean pain intensity of 2.95 ± 2.62 (range = 0–10), with patients recruited from the pain clinic reporting significantly higher pain intensity before the CPM assessment (3.51 ± 2.61) than patients from the outpatient clinics (2.54 ± 2.56, t = 4.57, P < 0.001). Only one control subject reported mild pain before the CPM assessment.

The average heat pain threshold was 38.95 ± 3.13°C and 38.71 ± 2.63°C for patients and control subjects, respectively (F = 1.17, P = 0.280). The average test temperature was 43.41 ± 2.38 and 42.84 ± 2.38°C for patients and control subjects, respectively (F = 4.33, P = 0.038, ω2 < 0.01). Heterogeneity within our patient sample was observed regarding the CPM efficiency (Fig. 1). The mean CPM efficiency for patients was −26.13% ± 43.20%. The mean CPM efficiency for control subjects was −32.47% ± 35.47% and was not significantly different from patients (F = 2.21, P = 0.137).

F1Figure 1.:

(A) Distribution of conditioned pain modulation (CPM) efficiency of the patient sample in which each bar represents one patient (n = 608). A negative value represents pain inhibition, whereas a positive value represents pain facilitation. The gray dotted lines mark the cutoffs for optimal (n = 293), suboptimal (n = 129), and inefficient (n = 186) CPM efficiency. (B–D) Mean pain intensity during the tonic thermal heat stimulations of the patients based on the different patterns of the CPM score: (B) optimal, (C) suboptimal, and (D) inefficient. A greater percentage difference in pain intensity during the tonic thermal heat stimulations demonstrates a greater CPM efficiency. CoVAS, computerized visual analog scale.

Heterogeneity within patients was also observed regarding the change in pain intensity during the last 60 seconds of TS1 (Fig. 2) and TS2 (Fig. 3). The mean reported change in pain intensity during the last 60 seconds of TS1 was 0.45 ± 21.70 in our patients and was significantly different from control subjects, whose mean reported change in pain intensity was 6.46 ± 19.05 (F = 4.92, P = 0.027, ω2 = 0.01). The mean reported change in pain intensity during the last 60 seconds of TS2 was 1.84 ± 19.05 in our patients, but was not significantly different from control subjects, whose mean reported change in pain intensity was 5.16 ± 14.49 (F = 1.63, P = 0.202).

F2Figure 2.:

(A) Distribution of the change in pain intensity during the tonic thermal heat stimulation before the conditioning stimulus (TS1) of the patient sample in which each bar represents one patient (n = 608). The gray dotted line marks the cutoffs for a significant decrease of −20/100 (n = 91), no change (n = 430), and a significant increase of 20/100 (n = 87) in pain intensity. (B–D) Mean pain intensity during the last 60 seconds of the tonic thermal heat stimulation before the conditioning stimulus of the patients based on the different patterns of change in pain intensity: (B) a decrease, (C) no change, or (D) an increase in pain intensity. CoVAS, computerized visual analog scale.

F3Figure 3.:

(A) Distribution of the change in pain intensity during the tonic thermal heat stimulation after the conditioning stimulus (TS2) of the patient sample, in which each bar represents one patient (n = 608). The gray dotted line marks the cutoffs for a significant decrease of −20/100 (n = 57), no change (n = 465), and a significant increase of 20/100 (n = 86) in pain intensity. (B–D) Mean pain intensity during the last 60 seconds of the tonic thermal heat stimulation after the conditioning stimulus of the patients based on the different patterns of change in pain intensity: (B) a decrease, (C) no change, or (D) an increase in pain intensity. CoVAS, computerized visual analog scale.

The mean reported pain intensity during the CS was 6.92 ± 2.44 and 6.31 ± 2.41 for patients and control subjects, respectively (F = 4.03, P = 0.027, ω2 < 0.01). Fifty-one patients and 6 control subjects removed their arm before the end of the 120 seconds. However, no difference in CPM efficiency was observed between the participants who completed the CPT and those who did not (data not shown).

A significant positive association was observed between the age of participants and their T50 (rho = 0.137, 95% CI = 0.059–0.212, P < 0.001) and their mean pain intensity during the CPT (rho = −0.086, 95% CI = −0.163–0.008, P = 0.027). Furthermore, a significant positive association was observed between the participants' T50 and the change in pain intensity during the temporal summation phase of the TS before (rho = 0.205, 95% CI = 0.129–0.279, P < 0.001) and after (rho = 0.218, 95% CI = 0.142–0.291, P < 0.001) the CPT. Other within-cohort differences or associations can be found in Supplementary Table 2 (available at https://links.lww.com/PR9/A172).

3.1. Cluster analysis

The best partition of clusters of the patient sample was 3 clusters accounting for 27.15% of the total variation in the data (Fig. 4). 271 patients (44.57%) were grouped in cluster 1, 186 (30.59%) in cluster 2, and 151 (24.84%) in cluster 3.

F4Figure 4.:

(A) Bar and (B) scatter plot of the indicator variables respective of the 3 clusters derived from the hierarchical cluster analysis with k-means. A score of zero is aligned with the mean of the sample. The P values of Fisher pairwise comparisons are shown. *P < 0.05; **P < 0.01; ***P < 0.05; ****P < 0.01. Bars = mean ± SEM. Points = individual patients. TSP1, change in pain intensity during last 60 seconds of the first test stimulus; CS, conditioning stimulus; TSP2, change in pain intensity during last 60 seconds of the second test stimulus; CPM; conditioned pain modulation efficiency. Patients grouped in cluster 1 are characterized by significantly lower values for TSP1, TSP2, and CPM efficiency compared with cluster 2 and 3. Patients grouped in cluster 3 are characterized by significantly higher values for TSP1, TSP2, and CPM efficiency compared with cluster 1 and 2. Patients in cluster 2 are characterized to have significantly lower values for CS compared with cluster 1 and 3.

No significant between-cluster difference was observed regarding their demographic characteristics (Table 1). However, significant differences were observed between clusters and control subjects regarding all CPM-related outcomes (ω2 ranging from 0.05 to 0.56) (Table 2).

Table 1 - Demographic characteristics of each cluster. Variable Cluster 1 (n = 271) Cluster 2 (n = 186) Cluster 3 (n = 151) Test statistic P Location of recruitment, n (%) 3.01* 0.222  Chronic pain clinic 106 (39.11) 81 (43.55) 72 (47.68)  Orthopedic outpatient clinic 165 (60.89) 105 (56.45) 79 (52.32) Age, mean ± SD (range) 15.15 ± 2.12 (8.2–21.4) 15.26 ± 1.86 (9.0–19.3) 15.15 ± 2.49 (8.3–21.0) 0.21† 0.810 Gender, n (%) 1.84* 0.398  Female 218 (80.44) 156 (83.87) 118 (78.15)  Male 53 (19.56) 30 (16.13) 33 (21.85) Duration of chronic pain, n (%) 1.93* 0.381  3–6 mo 18 (6.64) 9 (4.84) 13 (8.61)  More than 6 mo 253 (93.36) 177 (95.16) 138 (91.39) Type of chronic pain, n (%) 4.84* 0.089  Persistent 132 (48.71) 109 (58.60) 88 (58.28)  Recurrent 110 (40.59) 66 (35.48) 47 (31.13) Primary location of pain, n (%) 19.00* 0.165  Head/neck 14 (5.17) 13 (6.99) 4 (2.65)  Upper limbs 4 (1.48) 10 (5.38) 4 (2.65)  Thorax 6 (2.21) 6 (3.23) 2 (1.32)  Abdomen 12 (4.43) 9 (4.84) 3 (1.99)  Back 192 (70.85) 113 (60.75) 105 (69.53)  Groin 1 (0.37) 0 0  Lower limbs 41 (15.13) 35 (18.82) 33 (21.85) Presence of secondary pain sites, n (%) 2.89* 0.236  No 139 (51.29) 94 (50.54) 65 (43.04)  Yes 132 (48.71) 92 (49.46) 86 (56.96) Presence of pain before CPM assessment, n (%) 1.32* 0.516  No 79 (27.15) 49 (26.34) 48 (31.79)  Yes 188 (69.38) 137 (73.66) 102 (67.55)  Average pain intensity, mean ± SD (range) 3.08 ± 2.78 (0–10) 2.94 ± 2.50 (0–10) 2.73 ± 2.48 (0–8.5) 0.81† 0.444

*χ2 test statistic.

†One-way ANOVA test statistic controlled for gender.


Table 2 - Facilitatory and inhibitory pain responses of each cluster and control subjects. Variable Cluster 1 (n = 271) Cluster 2 (n = 186) Cluster 3 (n = 151) Control Subjects (n = 60) Test statistic P ω2 value Heat pain threshold (°C), mean ± SD 38.23 ± 2.90b 39.98 ± 3.33a,c 38.96 ± 2.92b 38.71 ± 2.63b 13.39* <0.001 0.05 Test temperature (°C), mean ± SD 42.70 ± 2.45b,c 44.39 ± 1.98a,c 43.49 ± 2.27a,b 42.84 ± 2.38b 22.04* <0.001 0.09 Change in pain intensity during the last 60 s of TS1 (NRS −100 to +100), mean ± SD −10.62 ± 20.17b,c 6.89 ± 17.72a 12.39 ± 19.23a 6.46 ± 19.05a 58.54* <0.001 0.21  Decrease, n (%) 73 (26.94) 12 (6.45) 6 (3.31) 5 (8.33) 97.73† <0.001  Constant, n (%) 189 (69.74) 139 (74.73) 102 (67.55) 43 (71.67)  Increase, n (%) 9 (3.32) 35 (18.82) 43 (28.48) 12 (20.00) Average pain intensity during CS (NRS 0–10), mean ± SD 8.16 ± 1.47b 4.04 ± 1.70a,c 8.24 ± 1.32b 6.31 ± 2.41a,b,c 287.23* <0.001 0.56 Change in pain intensity during the last 60 s of TS2 (NRS −100 to +100), mean ± SD −6.11 ± 16.42b,c 2.10 ± 14.11a,c 15.78 ± 20.66a,b 5.16 ± 14.49a,c 55.90* <0.001 0.2  Decrease, n (%) 39 (14.39) 11 (5.91) 7 (4.64) 4 (6.67) 110.15† <0.001  Constant, n (%) 222 (81.92) 157 (84.41) 86 (56.95) 47 (78.33)  Increase, n (%) 10 (3.69) 18 (9.68) 58 (38.41) 9 (15.00) CPM efficiency (%), mean ± SD −41.06 ± 34.19c −33.10 ± 37.84c 9.25 ± 44.27a,b −32.67 ± 35.47c 60.87* <0.001 0.21  Inefficient, n (%) 45 (16.61) 44 (23.66) 97 (64.24) 14 (23.33) 116.79† <0.001  Suboptimal, n (%) 61 (22.51) 44 (23.66) 24 (15.89) 12 (20.00)  Optimal, n (%) 165 (60.89) 98 (52.69) 30 (19.87) 34 (56.67)

a–c: Significant difference through Scheffé post hoc test (P < 0.05) from cluster 1 to cluster 3, respectively; ω2 value: 0.01 (small), 0.06 (medium), and 0.14 (large); TS1, tonic thermal heat stimulation before the conditioning stimulus; CS, conditioning stimulus; TS2, tonic thermal heat stimulation after the conditioning stimulus; CPM, conditioned pain modulation.

*One-way ANOVA test statistic controlled for gender.

†χ2 test statistic.

Patients in cluster 1 significantly displayed the lowest test temperature used for the TS and a higher proportion displayed a significant decrease in pain intensity (ie, −20/100) during the temporal summation phase of TS1 and TS2 (Fig. 5A). Patients in cluster 2 significantly displayed the highest test temperature used for the TS and the lowest average pain intensity reported during the CS. Interestingly, despite a large proportion of this cluster displaying optimal CPM efficiency similar to cluster 1, a larger proportion displayed a significant increase in pain intensity (ie, +20/100) during the temporal summation phase of TS1 and TS2 than cluster 1 (Fig. 5B). In contrast to cluster 1, patients grouped in cluster 3 significantly displayed a higher test temperature used for the TS, but lower than cluster 2, and a higher proportion displayed a significant increase in pain intensity during the temporal summation phase of TS1 and TS2 (Fig. 5C). Moreover, a larger proportion of cluster 3 displayed an inefficient CPM.

F5Figure 5.:

Mean pain intensity during the tonic thermal heat stimulations (A–D) and cold-pressor task (a–d) for each patient cluster and healthy control subjects. CoVAS, computerized visual analog scale; NRS, numerical rating scale.

When the clusters were compared with the control subjects, a significant difference in heat pain threshold (P = 0.025) and T50 (P < 0.001) was observed between cluster 2 and the control subjects. The heat pain threshold and T50 of control subjects were significantly lower than patients in cluster 2. A higher proportion of control subjects displayed a significant increase in pain intensity during the last 60 seconds of TS1 and TS2 than patients in cluster 1 (P < 0.001). However, a smaller proportion of control subjects displayed a significant increase in pain intensity during the last 60 seconds of TS2 than patients in cluster 3 (P = 0.002). The average pain intensity of control subjects during the CPT was significantly different to all clusters. When controlling for gender, the average pain during the CPT of patients in cluster 2 was significantly lower than control subjects (P < 0.001), whereas the average pain during the CPT of patients in cluster 1 (P < 0.001) and 3 (P < 0.001) was significantly higher than control subjects (Fig. 5D). The mean CPM efficiency of control subjects was optimal and significantly different (P < 0.001) from patients in cluster 3, which was inefficient.

4. Discussion

The objective of this study was to identify subgroups of patients with chronic pain based on their endogenous pain mechanisms. This analysis revealed heterogeneity in our patients regarding their facilitatory and inhibitory pain responses from one experimental design. We observed a significant association between the T50 and the age of the participants, and the change in pain intensity during the temporal summation phase of the TS. Furthermore, based on the CPM assessment outcomes of the patients, 3 subgroups were identified to best describe the patients. Cluster 1 was best characterized by high pain intensity during the CPT, lack of TSP, and efficient inhibitory CPM. Cluster 2 was best characterized by low pain intensity during the CPT, lack of TSP, and efficient inhibitory CPM. Cluster 3 was best characterized by high pain intensity during the CPT, presence of TSP, and inefficient inhibitory CPM.

A weak positive correlation was observed between the test temperature of the test stimuli of the participants and their age. Research in small samples of healthy children and adolescents or patients with type 1 diabetes mellitus have observed no correlation between age and heat-induced pain threshold.1,47 However, Blankenburg et al.5 observed a strong effect of age on heat pain threshold in a large population of healthy children and adolescents. Our findings extend their observation by demonstrating in a large population of pediatric sample with or without chronic pain that younger children are more sensitive to heat-induced pain. Age and sex have been shown to impact CPM in adult populations, such that male subjects have a greater CPM efficiency than female subjects, and older adults show less CPM.31 Only the effect of age has been observed in healthy youth, such that older children (12–17 years) showed greater CPM efficiency compared with younger children (8–11 years).44 In the current study, no association was observed between age or sex and CPM efficiency, and no age/sex differences were observed between clusters. Although it has been hypothesized that pain inhibitory mechanisms may develop throughout childhood and become stronger during adolescence, other predetermining factors may moderate the effect of age on CPM efficiency.

A significant difference in the average pain intensity reported during the CPT was observed between the patients and control subjects. The literature has shown conflicting results regarding pain responsivity in children with chronic pain during the CPT compared with control subjects.9,20,41,43 Because of individual variability in pain perception, a group difference in pain perception in previous studies with smaller sample sizes may be difficult to detect. Our large sample found a significant effect between groups that is small in magnitude but was more evident after cluster analysis, where patients grouped in cluster 1 and 3 reported significantly higher pain intensity during the CPT. Several aspects of the CPT methodology may also explain the conflicting results in the literature, such as CPT preparation, water temperature, immersion time, audience effects, arm removal, and measurement of pain outcomes.4 An advantage of the CPT is the opportunity to observe or explore the influence of psychosocial and cognitive factors on pain and to test new psychological interventions for pain.30,48 Holley et al. observed that higher state pain catastrophizing in youth with new-onset pain significantly predicted higher cold-pressor pain, but trait pain catastrophizing had an inverse relationship.20 This suggests that state and trait characteristics in our population of pediatric patients may have different patterns of relevance in their chronic and acute pain experiences and may explain why patients in cluster 1 and 3 displayed higher pain intensity during the cold-pressor task.

Patients grouped in cluster 3 displayed significant manifestation of impairment in central pain modulation, as observed in the presence of increased TSP during the test stimuli, and the large proportion of patients that displayed inefficient descending inhibitory pain control in this cluster, especially in comparison with control subjects. Studies in children and adolescents with chronic pain have observed overall lower inhibitory CPM response and facilitated temporal summation in comparison with control subjects.17 Walker et al.50 observed that a subgroup of pediatric patients with functional abdominal pain and met the criteria for functional gastrointestinal disorders at their follow-up appointment presented significantly greater thermal pain wind-up at their follow-up appointment, suggesting the involvement of central pain modulation in this transition. In our large population of patients, we observed a small proportion of patients (24.84%) displayed amplification in facilitatory pain mechanisms with impairment in inhibitory conditioned pain modulation responses. With such manifestation of impairment in central pain modulation, these patients are suggested to be at high propensity for widespread pain and comorbidities in the future.46,53 However, this was not investigated because of the cross-sectional nature of the analys

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