Sema3A Drives Alternative Macrophage Activation in the Resolution of Periodontitis via PI3K/AKT/mTOR Signaling

Tonetti, M.S., H. Greenwell, and K.S. Kornman. 2018. Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. Journal of Periodontology 89 (Suppl 1): S159–S172. https://doi.org/10.1002/JPER.18-0006.

Article  Google Scholar 

Nazir, M., A. Al-Ansari, K. Al-Khalifa, M. Alhareky, B. Gaffar, and K. Almas. 2020. Global prevalence of periodontal disease and lack of its surveillance. The Scientific World Journal 2020: 2146160. https://doi.org/10.1155/2020/2146160.

Article  Google Scholar 

Luo, L.S., H.H. Luan, J.F. Jiang, L. Wu, C. Li, W.D. Leng, and X.T. Zeng. 2022. The spatial and temporal trends of severe periodontitis burden in Asia, 1990–2019: A population-based epidemiological study. Journal of Periodontology 93: 1615–1625. https://doi.org/10.1002/JPER.21-0625.

Article  Google Scholar 

Lang, N.P., and P.M. Bartold. 2018. Periodontal health. Journal of Periodontology 89 (Suppl 1): S9–S16. https://doi.org/10.1002/JPER.16-0517.

Article  Google Scholar 

Pan, W., Q. Wang, and Q. Chen. 2019. The cytokine network involved in the host immune response to periodontitis. International Journal of Oral Science 11: 30. https://doi.org/10.1038/s41368-019-0064-z.

Article  CAS  Google Scholar 

Meyle, J., and I. Chapple. 2000. Molecular aspects of the pathogenesis of periodontitis. Periodontology 2015 (69): 7–17. https://doi.org/10.1111/prd.12104.

Article  Google Scholar 

Hajishengallis, G., and T. Chavakis. 2021. Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities. Nature reviews. Immunology 21: 426–440. https://doi.org/10.1038/s41577-020-00488-6.

Article  CAS  Google Scholar 

Zhang, X., Q. Wang, X. Yan, Y. Shan, L. Xing, M. Li, H. Long, and W. Lai. 2020. Immune landscape of periodontitis unveils alterations of infiltrating immunocytes and molecular networks-aggregating into an interactive web-tool for periodontitis related immune analysis and visualization. Journal of Translational Medicine 18: 438. https://doi.org/10.1186/s12967-020-02616-1.

Article  CAS  Google Scholar 

Di Stefano, M., A. Polizzi, S. Santonocito, A. Romano, T. Lombardi, and G. Isola. 2022. Impact of oral microbiome in periodontal health and periodontitis: A critical review on prevention and treatment. International Journal of Molecular Sciences 23. https://doi.org/10.3390/ijms23095142

Xue, J., S.V. Schmidt, J. Sander, A. Draffehn, W. Krebs, I. Quester, D. De Nardo, T.D. Gohel, M. Emde, L. Schmidleithner, H. Ganesan, A. Nino-Castro, M.R. Mallmann, L. Labzin, H. Theis, M. Kraut, M. Beyer, E. Latz, T.C. Freeman, T. Ulas, and J.L. Schultze. 2014. Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity 40: 274–288. https://doi.org/10.1016/j.immuni.2014.01.006.

Article  CAS  Google Scholar 

Karnes, J.M., S.D. Daffner, and C.M. Watkins. 2015. Multiple roles of tumor necrosis factor-alpha in fracture healing. Bone 78: 87–93. https://doi.org/10.1016/j.bone.2015.05.001.

Article  CAS  Google Scholar 

Lam, R.S., N.M. O’Brien-Simpson, J.A. Holden, J.C. Lenzo, S.B. Fong, and E.C. Reynolds. 2016. Unprimed, M1 and M2 macrophages differentially interact with Porphyromonas gingivalis. PLoS ONE 11: e0158629. https://doi.org/10.1371/journal.pone.0158629.

Article  CAS  Google Scholar 

Yang, J., Y. Zhu, D. Duan, P. Wang, Y. Xin, L. Bai, Y. Liu, and Y. Xu. 2018. Enhanced activity of macrophage M1/M2 phenotypes in periodontitis. Archives of Oral Biology 96: 234–242. https://doi.org/10.1016/j.archoralbio.2017.03.006.

Article  CAS  Google Scholar 

Zheng, X., S. Wang, L. Xiao, P. Han, K. Xie, S. Ivanovski, Y. Xiao, and Y. Zhou. 2022. LiCl-induced immunomodulatory periodontal regeneration via the activation of the Wnt/beta-catenin signaling pathway. Journal of Periodontal Research 57: 835–848. https://doi.org/10.1111/jre.13022.

Article  CAS  Google Scholar 

Miyashita, Y., R. Kuraji, H. Ito, and Y. Numabe. 2022. Wound healing in periodontal disease induces macrophage polarization characterized by different arginine-metabolizing enzymes. Journal of Periodontal Research 57: 357–370. https://doi.org/10.1111/jre.12965.

Article  CAS  Google Scholar 

Nakao, Y., T. Fukuda, Q. Zhang, T. Sanui, T. Shinjo, X. Kou, C. Chen, D. Liu, Y. Watanabe, C. Hayashi, H. Yamato, K. Yotsumoto, U. Tanaka, T. Taketomi, T. Uchiumi, A.D. Le, S. Shi, and F. Nishimura. 2021. Exosomes from TNF-alpha-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss. Acta Biomaterialia 122: 306–324. https://doi.org/10.1016/j.actbio.2020.12.046.

Article  CAS  Google Scholar 

Polleux, F., T. Morrow, and A. Ghosh. 2000. Semaphorin 3A is a chemoattractant for cortical apical dendrites. Nature 404: 567–573. https://doi.org/10.1038/35007001.

Article  CAS  Google Scholar 

Hayashi, M., T. Nakashima, M. Taniguchi, T. Kodama, A. Kumanogoh, and H. Takayanagi. 2012. Osteoprotection by semaphorin 3A. Nature 485: 69–74. https://doi.org/10.1038/nature11000.

Article  CAS  Google Scholar 

Xu, R. 2014. Semaphorin 3A: A new player in bone remodeling. Cell Adhesion & Migration 8: 5–10. https://doi.org/10.4161/cam.27752.

Article  Google Scholar 

Li, Y., L. Yang, S. He, and J. Hu. 2015. The effect of semaphorin 3A on fracture healing in osteoporotic rats. Journal of Orthopaedic Science 20: 1114–1121. https://doi.org/10.1007/s00776-015-0771-z.

Article  CAS  Google Scholar 

Ranganathan, P., C. Jayakumar, R. Mohamed, N.L. Weintraub, and G. Ramesh. 2014. Semaphorin 3A inactivation suppresses ischemia-reperfusion-induced inflammation and acute kidney injury. American Journal of Physiology-Renal Physiology 307: F183–F194. https://doi.org/10.1152/ajprenal.00177.2014.

Article  CAS  Google Scholar 

Liu, L.N., X.M. Li, D.Q. Ye, and H.F. Pan. 2018. Emerging role of semaphorin-3A in autoimmune diseases. Inflammopharmacology 26: 655–665. https://doi.org/10.1007/s10787-018-0484-y.

Article  CAS  Google Scholar 

Rienks, M., P. Carai, N. Bitsch, M. Schellings, M. Vanhaverbeke, J. Verjans, I. Cuijpers, S. Heymans, and A. Papageorgiou. 2017. Sema3A promotes the resolution of cardiac inflammation after myocardial infarction. Basic Research in Cardiology 112: 42. https://doi.org/10.1007/s00395-017-0630-5.

Article  CAS  Google Scholar 

Vergadi, E., E. Ieronymaki, K. Lyroni, K. Vaporidi, and C. Tsatsanis. 2017. Akt signaling pathway in macrophage activation and M1/M2 polarization. Journal of Immunology (Baltimore, Md. : 1950) 198:1006–1014. https://doi.org/10.4049/jimmunol.1601515

Braun, C., K. Katholnig, C. Kaltenecker, M. Linke, N. Sukhbaatar, M. Hengstschlager, and T. Weichhart. 2021. p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway. Cell Stress 5:176–182. https://doi.org/10.15698/cst2021.12.260

Souza, J.A.C., A.V.B. Nogueira, P.P.C. Souza, G. Oliveira, M.C. Medeiros, G.P. Garlet, J.A. Cirelli, and C.J. Rossa. 2017. Suppressor of cytokine signaling 1 expression during LPS-induced inflammation and bone loss in rats. Brazilian Oral Research 31: e75. https://doi.org/10.1590/1807-3107BOR-2017.vol31.0075.

Article  Google Scholar 

Petean, I.B.F., L.A. Almeida-Junior, M.F.M. Arnez, A.M. Queiroz, R.A.B. Silva, L.A.B. Silva, L.H. Faccioli, and F.W.G. Paula-Silva. 2021. Celecoxib treatment dampens LPS-induced periapical bone resorption in a mouse model. International Endodontic Journal 54: 1289–1299. https://doi.org/10.1111/iej.13472.

Article  CAS  Google Scholar 

Mukherjee, S., R. Hussaini, R. White, D. Atwi, A. Fried, S. Sampat, L. Piao, Q. Pan, and P. Banerjee. 2018. TriCurin, a synergistic formulation of curcumin, resveratrol, and epicatechin gallate, repolarizes tumor-associated macrophages and triggers an immune response to cause suppression of HPV+ tumors. Cancer Immunology, Immunotherapy 67: 761–774. https://doi.org/10.1007/s00262-018-2130-3.

Article  CAS  Google Scholar 

Yang, B., X. Pang, Z. Li, Z. Chen, and Y. Wang. 2021. Immunomodulation in the treatment of periodontitis: Progress and perspectives. Frontiers in immunology 12: 781378. https://doi.org/10.3389/fimmu.2021.781378.

Article  CAS  Google Scholar 

Wang, W., C. Zheng, J. Yang, and B. Li. 2021. Intersection between macrophages and periodontal pathogens in periodontitis. Journal of Leukocyte Biology 110: 577–583. https://doi.org/10.1002/JLB.4MR0421-756R.

Article  CAS  Google Scholar 

Liu, H., J. Xia, Y. Chen, J. Ai, T. Wang, and G. Tan. 2021. Immunosuppressive regulation of dendritic cells and T cells in allergic rhinitis by semaphorin 3A. American Journal of Rhinology & Allergy 35: 846–853. https://doi.org/10.1177/19458924211005592.

Article  Google Scholar 

Casazza, A., D. Laoui, M. Wenes, S. Rizzolio, N. Bassani, M. Mambretti, S. Deschoemaeker, J.A. Van Ginderachter, L. Tamagnone, and M. Mazzone. 2013. Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity. Cancer Cell 24: 695–709. https://doi.org/10.1016/j.ccr.2013.11.007.

Article  CAS  Google Scholar 

Teng, Y., Z. Yin, J. Li, K. Li, X. Li, and Y. Zhang. 2017. Adenovirus-mediated delivery of Sema3A alleviates rheumatoid arthritis in a serum-transfer induced mouse model. Oncotarget 8: 66270–66280. https://doi.org/10.18632/oncotarget.19915

Preshaw, P.M., and J.J. Taylor. 2011. How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis? Journal of Clinical Periodontology 38 (Suppl 11): 60–84. https://doi.org/10.1111/j.1600-051X.2010.01671.x.

Article  Google Scholar 

Naruishi, K., and T. Nagata. 2018. Biological effects of interleukin-6 on gingival fibroblasts: Cytokine regulation in periodontitis. Journal of Cellular Physiology 233: 6393–6400. https://doi.org/10.1002/jcp.26521.

Article  CAS  Google Scholar 

Luo, G., F. Li, X. Li, Z.G. Wang, and B. Zhang. 2018. TNF-alpha and RANKL promote osteoclastogenesis by upregulating RANK via the NF-kappaB pathway. Molecular Medicine Reports 17: 6605–6611. https://doi.org/10.3892/mmr.2018.8698.

Article  CAS  Google Scholar 

Marahleh, A., H. Kitaura, F. Ohori, A. Kishikawa, S. Ogawa, W.R. Shen, J. Qi, T. Noguchi, Y. Nara, and I. Mizoguchi. 2019. TNF-alpha Directly enhances osteocyte RANKL expression and promotes osteoclast formation. Frontiers in immunology 10: 2925. https://doi.org/10.3389/fimmu.2019.02925.

Article  CAS  Google Scholar 

Metcalfe, S., N. Anselmi, A. Escobar, M.B. Visser, and J.G. Kay. 2021. Innate phagocyte polarization in the oral cavity. Frontiers in immunology 12: 768479. https://doi.org/10.3389/fimmu.2021.768479.

Article  CAS  Google Scholar 

Ruffell, B., and L.M. Coussens. 2015. Macrophages and therapeutic resistance in cancer. Cancer Cell 27: 462–472. https://doi.org/10.1016/j.ccell.2015.02.015.

Article  CAS  Google Scholar 

Afik, R., E. Zigmond, M. Vugman, M. Klepfish, E. Shimshoni, M. Pasmanik-Chor, A. Shenoy, E. Bassat, Z. Halpern, T. Geiger, I. Sagi, and C. Varol. 2016. Tumor macrophages are pivotal constructors of tumor collagenous matrix. The Journal of Experimental Medicine 213: 2315–2331. https://doi.org/10.1084/jem.20151193.

Article  CAS  Google Scholar 

Olmsted-Davis, E., J. Mejia, E. Salisbury, Z. Gugala, and A.R. Davis. 2021. A Population of M2 macrophages associated with bone formation. Frontiers in immunology 12: 686769. https://doi.org/10.3389/fimmu.2021.686769.

Article  CAS  Google Scholar 

Miao, Y., L. He, X. Qi, and X. Lin. 2020. Injecting immunosuppressive M2 macrophages alleviates the symptoms of periodontitis in mice. Frontiers in Molecular Biosciences 7: 603817. https://doi.org/10.3389/fmolb.2020.603817.

Article  CAS  Google Scholar 

Oliveira Costa, F., L.O. Miranda Cota, E.J. Pereira Lages, T.C. Medeiros Lorentz, A.M. Soares Dutra Oliveira, P.A. Dutra Oliveira, and J.E. Costa. 2011. Progression of periodontitis in a sample of regular and irregular compliers under maintenance therapy: A 3-year follow-up study. Journal of Periodontology 82:1279–87. https://doi.org/10.1902/jop.2011.100664

Schwendicke, F., M. Stolpe, A. Plaumann, and C. Graetz. 2016. Cost-effectiveness of regular versus irregular supportive periodontal therapy or tooth removal. Journal o

留言 (0)

沒有登入
gif