Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/61131

metadata.dc.identifier.doi: https://doi.org/10.56042/ijeb.v61i01.59740Title: Modulatory effects of Saccharomyces cerevisiae var. boulardii on experimentally induced benign prostatic hyperplasia in ratsAuthors: Onoja, Remigius I
Joshua, Parker E
Obidah, Wilson
Onyekaba, Alloysius C
Mgbeahurike, Anthony C
Emesiani, Benjamin IKeywords: Dihydrotestosterone;Probiotic;Prostate gland;Rodents;Testosterone propionate;YeastIssue Date: Jan-2023Publisher: NIScPR-CSIR,IndiaAbstract: Benign prostatic hyperplasia (BPH) is an age-related non-neoplastic disease of the prostate gland in men that has become a global health issue in recent years. Due to the side effects of conventional treatment options, attention is now focused on phytotherapeutics for its management. We investigated the possible protective effect of Saccharomyces cerevisiae var. boulardii in a rat model of testosterone propionate (TP) induced BPH. Rats were divided into five groups: Gr. I, untreated control group; Gr. II, TP group; Gr. III, TP + finasteride; Gr. IV, TP + S. cerevisiae var. boulardii; and Gr. V, S. cerevisiae var. boulardii group. Treatments were given daily for 28 days. At the end of the experiment, all rats were weighed and the prostatic indices, prostate specific antigen, serum testosterone concentration as well as the histological and histomorphometric changes were evaluated. Saccharomyces cerevisiae var. boulardii significantly (P Page(s): 25-32ISSN: 0975-1009 (Online); 0019-5189 (Print)Appears in Collections:IJEB Vol.61(01) [Jan 2023]

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