Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/61130

metadata.dc.identifier.doi: https://doi.org/10.56042/ijeb.v61i01.45656Title: Antifertility activity of Oroxylum indicum (L.) Kurz: In vitro and in vivo study on human sperm and male wistar ratsAuthors: Das, Banani
Roy, Kalyan
Talukdar, Anupam Das
Dey, Amitabha
Nongalleima, Khumukcham
Das, Supriya
Sharma, Prasanti
Choudhury, Manabendra Dutta
Deb, LokeshKeywords: Baicalin;Broken bones tree;Contraceptive;Indian trumpet flower;Kampong;Oroxylin;Sperm motility;TestosteroneIssue Date: Jan-2023Publisher: NIScPR-CSIR,IndiaAbstract: Oroxylum indicum (L.) Kurz, commonly called as Broken bones tree or Indian trumpet flower, belonging to Fam. Bignoniaceae, is traditionally used as a contraceptive by ethnic people of Tripura, North-East India. Here, we investigated the scientific basis for use of O. indicum as male antifertility agent by folklore healers. In vitro spermicidal activity of aqueous (AEOI) and methanolic (MEOI) extracts of O. indicum stem bark were studied on human sperm. The in vivo activity was experimented on male albino rats. The treated animals were allowed to mate and the pups delivered by female rat partners were counted. Phytochemical estimation of test samples was done using HPLC. The AEOI and MEOI treatments significantly decreased human sperm motility and viability. Test extracts have increased the hypo-osmotic swelling of sperm. Both the extracts were significantly declined the weight of reproductive organ. The MEOI treated rats have shown significant decrease in sperm motility and sperm counts. AEOI and MEOI treatment significantly reduced level of testosterone, but sharply raised dihydrotestosterone and prostaglandin in rats. Results testified the traditional claim for use of O. indicum as a male contraceptive agent, where MEOI have shown reversible action on male reproductive system leading to contraception without harming the libido.Page(s): 33-41ISSN: 0975-1009 (Online); 0019-5189 (Print)Appears in Collections:IJEB Vol.61(01) [Jan 2023]

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