Weber C, Noels H. Atherosclerosis: current pathogenesis and therapeutic options. Nat Med. 17:1410–22.

Santovito D, Weber C. Atherosclerosis revisited from a clinical perspective: still an inflammatory disease? Thromb Haemost. 2017;117:231–7.

Article  Google Scholar 

Gimbrone MA Jr, García-Cardeña G. Endothelial cell sysfunction and the pathobiology of atherosclerosis. Circ Res. 2016;118:620–36.

Article  CAS  Google Scholar 

Pirillo A, Norata GD, Catapano AL. LOX-1, OxLDL, and atherosclerosis. Mediators Inflamm. 2013;2013:152786.

Article  Google Scholar 

Gao S, Zhao D, Wang M, et al. Association between circulating oxidized LDL and atherosclerotic cardiovascular disease: a meta-analysis of observational studies. Can J Cardiol. 2017;33:1624–32.

Article  Google Scholar 

Takenaka T, Takahashi K, Kobayashi T, Oshima E, Iwasaki S, Suzuki H. Oxidized low density lipoprotein (Ox-LDL) as a marker of atherosclerosis in hemodialysis (HD) patients. Clin Nephrol. 2002;58:33–7.

Article  CAS  Google Scholar 

Liu J, Liu T, Wang X, He A. Circles reshaping the RNA world: from waste to treasure. Mol Cancer. 2017;16:58.

Article  CAS  Google Scholar 

Chen LL. The biogenesis and emerging roles of circular RNAs. Nat Rev Mol Cell Biol. 2016;17:205–11.

Article  CAS  Google Scholar 

Arnaiz E, Sole C, Manterola L, Iparraguirre L, Otaegui D, Lawrie CH. CircRNAs and cancer: Biomarkers and master regulators. Semin Cancer Biol. 2019;58:90–9.

Article  CAS  Google Scholar 

Vo JN, Cieslik M, Zhang Y, Shukla S, Xiao L, Zhang Y, et al. The landscape of circular RNA in cancer. Cell. 2019;176:869–81.e13.

Article  CAS  Google Scholar 

Kong P, Yu Y, Wang L, et al. circ-Sirt1 controls NF-κB activation via sequence-specific interaction and enhancement of SIRT1 expression by binding to miR-132/212 in vascular smooth muscle cells. Nucleic Acids Res. 2019;47:3580–93.

Article  CAS  Google Scholar 

Altesha MA, Ni T, Khan A, Liu K, Zheng X. Circular RNA in cardiovascular disease. J Cell Physiol. 2019;234:5588–600.

Article  CAS  Google Scholar 

Huang HS, Huang XY, Yu HZ, Xue Y, Zhu PL. Circular RNA circ-RELL1 regulates inflammatory response by miR-6873-3p/MyD88/NF-κB axis in endothelial cells. Biochem Biophys Res Commun. 2020;525:512–9.

Article  CAS  Google Scholar 

Gu Y, Ma X, Li J, Ma Y, Zhang Y. Identification of candidate targets for the diagnosis and treatment of atherosclerosis by bioinformatics analysis. Am J Transl Res. 2021;13:4137–51.

CAS  Google Scholar 

Han B, Chao J, Yao H. Circular RNA and its mechanisms in disease: from the bench to the clinic. Pharmacol Ther. 2018;187:31–44.

Article  CAS  Google Scholar 

Juźwik CA, Drake SS, Zhang Y, et al. microRNA dysregulation in neurodegenerative diseases: A systematic review. Prog Neurobiol. 2019;182:101664.

Article  Google Scholar 

Andreou I, Sun X, Stone PH, Edelman ER, Feinberg MW. miRNAs in atherosclerotic plaque initiation, progression, and rupture. Trends Mol Med. 21:307–18.

Peng W, Li S, Chen S, Yang J, Sun Z. Hsa_circ_0003204 knockdown weakens Ox-LDL-Induced cell injury by regulating miR-188-3p/TRPC6 axis in human carotid artery endothelial cells and THP-1 cells. Front Cardiovasc Med. 2021;8:731890.

Article  CAS  Google Scholar 

Gu S, Jin L, Zhang F, Sarnow P, Kay MA. Biological basis for restriction of microRNA targets to the 3' untranslated region in mammalian mRNAs. Nat Struct Mol Biol. 2009;16:144–50.

Article  CAS  Google Scholar 

de Vicente LG, Pinto AP, da Rocha AL, Pauli JR, de Moura LP, Cintra DE, et al. Role of TLR4 in physical exercise and cardiovascular diseases. Cytokine. 2020;136:155273.

Article  Google Scholar 

Hansen TB, Jensen TI, Clausen BH, et al. Natural RNA circles function as efficient microRNA sponges. Nature. 2013;495:384.

Article  CAS  Google Scholar 

Galkina E, Ley K. Immune and inflammatory mechanisms of atherosclerosis (*). Annu Rev Immunol. 2009;27:165–97.

Article  CAS  Google Scholar 

Tousoulis D, Simopoulou C, Papageorgiou N, et al. Endothelial dysfunction in conduit arteries and in microcirculation. Novel therapeutic approaches. Pharmacol Ther. 2014;144:253–67.

Article  CAS  Google Scholar 

Davignon J, Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation. 2004;109:Iii27–32.

Article  Google Scholar 

Park HJ, Zhang Y, Georgescu SP, Johnson KL, Kong D, Galper JB. Human umbilical vein endothelial cells and human dermal microvascular endothelial cells offer new insights into the relationship between lipid metabolism and angiogenesis. Stem Cell Rev. 2006;2:93–102.

Article  CAS  Google Scholar 

Zhang Y, Zhang X-O, Chen T, et al. Circular intronic long noncoding RNAs. Mol Cell. 2013;51:792–806.

Article  CAS  Google Scholar 

Ng WL, Mohd Mohidin TB, Shukla K. Functional role of circular RNAs in cancer development and progression. RNA Biol. 2018;15:995–1005.

Google Scholar 

Wan H, You T, Luo W. Circ_0003204 regulates cell growth, oxidative stress, and inflammation in ox-LDL-induced vascular endothelial cells via regulating miR-942-5p/HDAC9 axis. Front Cardiovasc Med. 2021;8:646832.

Article  Google Scholar 

Chen W, Guo S, Li X, Song N, Wang D, Yu R. The regulated profile of noncoding RNAs associated with inflammation by tanshinone IIA on atherosclerosis. J Leukoc Biol. 2020;108:243–52.

Article  CAS  Google Scholar 

Wang G, Li Y, Liu Z, et al. Circular RNA circ_0124644 exacerbates the ox-LDL-induced endothelial injury in human vascular endothelial cells through regulating PAPP-A by acting as a sponge of miR-149-5p. Mol Cell Biochem. 2020;471:51–61.

Article  CAS  Google Scholar 

Zhang C, Wang L, Shen Y. Circ_0004104 knockdown alleviates oxidized low-density lipoprotein-induced dysfunction in vascular endothelial cells through targeting miR-328-3p/TRIM14 axis in atherosclerosis. BMC Cardiovasc Disord. 2021;21:207.

Article  Google Scholar 

Pei J, Zhang J, Yang X, et al. TMED3 promotes cell proliferation and motility in breast cancer and is negatively modulated by miR-188-3p. Cancer Cell Int. 2019;19:75.

Article  Google Scholar 

Luo Z, Fan Y, Liu X, et al. MiR-188-3p and miR-133b suppress cell proliferation in human hepatocellular carcinoma via post-transcriptional suppression of NDRG1. Technol Cancer Res Treat. 2021;20:15330338211033074.

Article  CAS  Google Scholar 

Mi S, Wang P, Lin L. miR-188-3p inhibits vascular smooth muscle cell proliferation and migration by targeting fibroblast Ggrowth factor 1 (FGF1). Med Sci Monit. 2020;26:e924394.

Article  CAS  Google Scholar 

Zhang XF, Yang Y, Yang XY, Tong Q. MiR-188-3p upregulation results in the inhibition of macrophage proinflammatory activities and atherosclerosis in ApoE-deficient mice. Thromb Res. 2018;171:55–61.

Article  CAS  Google Scholar 

Fabian MR, Sonenberg N, Filipowicz W. Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem. 2010;79:351–79.

Article  CAS  Google Scholar 

Yang K, He YS, Wang XQ, et al. MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-like receptor 4. FEBS Lett. 2011;585:854–60.

Article  CAS  Google Scholar 

Du XJ, Lu JM. MiR-135a represses oxidative stress and vascular inflammatory events via targeting toll-like receptor 4 in atherogenesis. J Cell Biochem. 2018;119:6154–61.

Article  CAS  Google Scholar 

Yang K, Xue Y, Gao X. LncRNA XIST promotes atherosclerosis by regulating miR-599/TLR4 axis. Inflammation. 2021;44:965–73.

Article  CAS  Google Scholar 

Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol. 2009;1:a001651.

Article  Google Scholar 

Balzan S, Lubrano V. LOX-1 receptor: a potential link in atherosclerosis and cancer. Life Sci. 2018;198:79–86.

Article  CAS  Google Scholar 

Cocucci E, Meldolesi J. Ectosomes and exosomes: shedding the confusion between extracellular vesicles. Trends Cell Biol. 2015;25:364–72.

Article  CAS  Google Scholar 

Vlassov AV, Magdaleno S, Setterquist R, Conrad R. Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim Biophys Acta. 2012;1820:940–8.

Article  CAS  Google Scholar 

Ge R, Tan E, Sharghi-Namini S, Asada HH. Exosomes in Cancer Microenvironment and Beyond: have we overlooked these extracellular messengers? Cancer Microenviron. 2012;5:323–32.

Article  CAS  Google Scholar 

Li Y, Feng W, Kong M, et al. Exosomal circRNAs: a new star in cancer. Life Sci. 2021;269:119039.

Article  CAS  Google Scholar