Heitzer E, Auinger L, Speicher MR. Cell-free DNA and apoptosis: how dead cells inform about the living. Trends Mol Med England. 2020;26:519–28.

Article  Google Scholar 

Snyder MW, Kircher M, Hill AJ, Daza RM, Shendure J. Cell-free DNA comprises an in vivo nucleosome footprint that informs its tissues-of-origin. Cell. 2016;164:57–68.

Article  Google Scholar 

Dor Y, Cedar H. Principles of DNA methylation and their implications for biology and medicine. Lancet (London, England). 2018;392:777–86.

Article  Google Scholar 

Guo S, Diep D, Plongthongkum N, Fung H-L, Zhang K, Zhang K. Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA. Nat Genet. 2017;49:635–42.

Article  Google Scholar 

Li W, Li Q, Kang S, Same M, Zhou Y, Sun C, et al. CancerDetector: ultrasensitive and non-invasive cancer detection at the resolution of individual reads using cell-free DNA methylation sequencing data. Nucleic Acids Res. 2018;46:e89.

Article  Google Scholar 

Kang S, Li Q, Chen Q, Zhou Y, Park S, Lee G, et al. CancerLocator: non-invasive cancer diagnosis and tissue-of-origin prediction using methylation profiles of cell-free DNA. Genome Biol. 2017;18:53.

Article  Google Scholar 

Sun K, Jiang P, Chan KCA, Wong J, Cheng YKY, Liang RHS, et al. Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments. Proc Natl Acad Sci U S A. 2015;112:E5503–12.

Article  Google Scholar 

Moss J, Magenheim J, Neiman D, Zemmour H, Loyfer N, Korach A, et al. Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease. Nat Commun. 2018;9:5068.

Article  Google Scholar 

Xu R-H, Wei W, Krawczyk M, Wang W, Luo H, Flagg K, et al. Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma. Nat Mater. 2017;16:1155–61.

Article  Google Scholar 

Legendre C, Gooden GC, Johnson K, Martinez RA, Liang WS, Salhia B. Whole-genome bisulfite sequencing of cell-free DNA identifies signature associated with metastatic breast cancer. Clin Epigenetics. 2015;7:100.

Article  Google Scholar 

Gallardo-Gómez M, Moran S, Páez de la Cadena M, Martínez-Zorzano VS, Rodríguez-Berrocal FJ, Rodríguez-Girondo M, et al. A new approach to epigenome-wide discovery of non-invasive methylation biomarkers for colorectal cancer screening in circulating cell-free DNA using pooled samples. Clin Epigenetics. 2018;10:53.

Article  Google Scholar 

Gordevičius J, Kriščiūnas A, Groot DE, Yip SM, Susic M, Kwan A, et al. Cell-free DNA modification dynamics in abiraterone acetate-treated prostate Cancer patients. Clin cancer Res an Off J Am Assoc Cancer Res. 2018;24:3317–24.

Article  Google Scholar 

Lu H, Liu Y, Wang J, Fu S, Wang L, Huang C, et al. Detection of ovarian cancer using plasma cell-free DNA methylomes. Clin Epigenetics. 2022;14:74.

Article  Google Scholar 

Shen SY, Burgener JM, Bratman SV, De Carvalho DD. Preparation of cfMeDIP-seq libraries for methylome profiling of plasma cell-free DNA. Nat Protoc. 2019;14:2749–80.

Article  Google Scholar 

Engel JJ, Pitkänen A. Biomarkers for epileptogenesis and its treatment. Neuropharmacology. 2020;167:107735.

Article  Google Scholar 

Henshall DC, Hamer HM, Pasterkamp RJ, Goldstein DB, Kjems J, Prehn JHM, et al. MicroRNAs in epilepsy: pathophysiology and clinical utility. Lancet Neurol. 2016;15:1368–76.

Article  Google Scholar 

Blümcke I, Thom M, Aronica E, Armstrong DD, Bartolomei F, Bernasconi A, et al. International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a task force report from the ILAE commission on diagnostic methods. Epilepsia. 2013;54:1315–29.

Article  Google Scholar 

Treiman DM. GABAergic mechanisms in epilepsy. Epilepsia. 2001;42:8 Suppl 3-12.

Article  Google Scholar 

Maljevic S, Møller RS, Reid CA, Pérez-Palma E, Lal D, May P, et al. Spectrum of GABAA receptor variants in epilepsy. Curr Opin Neurol. 2019;32:183–90.

Article  Google Scholar 

Wang CS, Kavalali ET, Monteggia LM. BDNF signaling in context: From synaptic regulation to psychiatric disorders. Cell. 2022;185:62–76.

Article  Google Scholar 

Chen WG, Chang Q, Lin Y, Meissner A, West AE, Griffith EC, et al. Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science. 2003;302:885–9.

Article  Google Scholar 

Dugich-Djordjevic MM, Tocco G, Willoughby DA, Najm I, Pasinetti G, Thompson RF, et al. BDNF mRNA expression in the developing rat brain following kainic acid-induced seizure activity. Neuron. 1992;8:1127–38.

Article  Google Scholar 

Poulsen FR, Lauterborn J, Zimmer J, Gall CM. Differential expression of brain-derived neurotrophic factor transcripts after pilocarpine-induced seizure-like activity is related to mode of Ca2+ entry. Neuroscience. 2004;126:665–76.

Article  Google Scholar 

Zhang HN, Ko MC. Seizure activity involved in the up-regulation of BDNF mRNA expression by activation of central mu opioid receptors. Neuroscience. 2009;161:301–10.

Article  Google Scholar 

Murray KD, Isackson PJ, Eskin TA, King MA, Montesinos SP, Abraham LA, et al. Altered mRNA expression for brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase in the hippocampus of patients with intractable temporal lobe epilepsy. J Comp Neurol. 2000;418:411–22.

Article  Google Scholar 

Takahashi M, Hayashi S, Kakita A, Wakabayashi K, Fukuda M, Kameyama S, et al. Patients with temporal lobe epilepsy show an increase in brain-derived neurotrophic factor protein and its correlation with neuropeptide Y. Brain Res. 1999;818:579–82.

Article  Google Scholar 

Ryley Parrish R, Albertson AJ, Buckingham SC, Hablitz JJ, Mascia KL, Davis Haselden W, et al. Status epilepticus triggers early and late alterations in brain-derived neurotrophic factor and NMDA glutamate receptor Grin2b DNA methylation levels in the hippocampus. Neuroscience. 2013;248:602–19.

Article  Google Scholar 

Martínez-Levy GA, Rocha L, Lubin FD, Alonso-Vanegas MA, Nani A, Buentello-García RM, et al. Increased expression of BDNF transcript with exon VI in hippocampi of patients with pharmaco-resistant temporal lobe epilepsy. Neuroscience. 2016;314:12–21.

Article  Google Scholar 

Bandeira IC, Giombelli L, Werlang IC, Abujamra AL, Secchi TL, Brondani R, et al. Methylation of BDNF and SLC6A4 gene promoters in Brazilian patients with temporal lobe epilepsy presenting or not psychiatric comorbidities. Front Integr Neurosci. 2021;15:764742.

Article  Google Scholar 

Martins-Ferreira R, Leal B, Chaves J, Li T, Ciudad L, Rangel R, et al. Epilepsy progression is associated with cumulative DNA methylation changes in inflammatory genes. Prog Neurobiol. 2021;209:102207.

Article  Google Scholar 

Chatterton Z, Mendelev N, Chen S, Carr W, Kamimori GH, Ge Y, et al. Bisulfite amplicon sequencing can detect glia and neuron cell-free DNA in blood plasma. Front Mol Neurosci. 2021;14:672614.

Article  Google Scholar 

Alapirtti T, Jylhävä J, Raitanen J, Mäkinen R, Peltola J, Hurme MA, et al. The concentration of cell-free DNA in video-EEG patients is dependent on the epilepsy syndrome and duration of epilepsy. Neurol Res. 2016;38:45–50.

Article  Google Scholar 

Liimatainen SP, Jylhävä J, Raitanen J, Peltola JT, Hurme MA. The concentration of cell-free DNA in focal epilepsy. Epilepsy Res. 2013;105:292–8.

Article  Google Scholar 

Shen SY, Singhania R, Fehringer G, Chakravarthy A, Roehrl MHA, Chadwick D, et al. Sensitive tumour detection and classification using plasma cell-free DNA methylomes. Nature. 2018;563:579–83.

Article  Google Scholar 

Herrgott GA, Asmaro KP, Wells M, Sabedot TS, Malta TM, Mosella MS, et al. Detection of tumor-specific DNA methylation markers in the blood of patients with pituitary neuroendocrine tumors. Neuro Oncol. 2022;24(7):1126–39.

Article  Google Scholar 

Sabedot TS, Malta TM, Snyder J, Nelson K, Wells M, deCarvalho AC, et al. A serum-based DNA methylation assay provides accurate detection of glioma. Neuro Oncol. 2021;23:1494–508.

Article  Google Scholar 

Long H-Y, Feng L, Kang J, Luo Z-H, Xiao W-B, Long L-L, et al. Blood DNA methylation pattern is altered in mesial temporal lobe epilepsy. Sci Rep. 2017;7:43810.

Article  Google Scholar 

Tao H, Chen Z, Wu J, Chen J, Chen Y, Fu J, et al. DNA methylation signature of epileptic encephalopathy-related pathogenic genes encoding ion channels in temporal lobe epilepsy. Front Neurol. 2021;12:692412.

Article  Google Scholar 

Braun PR, Han S, Hing B, Nagahama Y, Gaul LN, Heinzman JT, et al. Genome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals. Transl Psychiatry. 2019;9:47.

Article  Google Scholar 

Simón-Sánchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, Berg D, et al. Genome-wide association study reveals genetic risk underlying Parkinson’s disease. Nat Genet. 2009;41:1308–12.

Article  Google Scholar 

Sanchez-Mut JV, Heyn H, Silva BA, Dixsaut L, Garcia-Esparcia P, Vidal E, et al. PM20D1 is a quantitative trait locus associated with Alzheimer’s disease. Nat Med. 2018;24:598–603.

Article  Google Scholar 

Wang Q, Chen Y, Readhead B, Chen K, Su Y, Reiman EM, et al. Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer’s disease and implicate its dynamic role in disease progression. Clin Epigenetics. 2020;12:189.

Article  Google Scholar 

Lie AA, Schröder R, Blümcke I, Magin TM, Wiestler OD, Elger CE. Plectin in the human central nervous system: predominant expression at pia/glia and endothelia/glia interfaces. Acta Neuropathol. 1998;96:215–21.

Article  Google Scholar 

Potokar M, Jorgačevski J. Plectin in the central nervous system and a putative role in brain astrocytes. Cells. 2021;10:2353.

Article  Google Scholar 

Lee T-S, Mane S, Eid T, Zhao H, Lin A, Guan Z, et al. Gene expression in temporal lobe epilepsy is consistent with increased release of glutamate by astrocytes. Mol Med. 2007;13:1–13.

Article  Google Scholar 

Hori K, Shimaoka K, Hoshino M. AUTS2 Gene: keys to understanding the pathogenesis of neurodevelopmental disorders. Cells. 2021;11:11.

Article  Google Scholar 

Gao Z, Lee P, Stafford JM, von Schimmelmann M, Schaefer A, Reinberg D. An AUTS2-Polycomb complex activates gene expression in the CNS. Nature. 2014;516:349–54.

Article  Google Scholar 

Bahado-Singh RO, Radhakrishna U, Gordevičius J, Aydas B, Yilmaz A, Jafar F, et al. Artificial intelligence and circulating cell-free DNA methylation profiling: mechanism and detection of Alzheimer’s disease. Cells. 2022;11:1744.

Article  Google Scholar 

Wieser H-G. ILAE commission. Report mesial temporal lobe epilepsy with hippocampal sclerosis. Epilepsia. 2004;45(6):695–714.