HDACsClass IHDAC1NucleusH3K9ac, H3K14ac, H3K18ac, H3K23ac, H3K27ac [22]p53 (K382ac) [23], Hsp70 [24], STAT3 [25], E2F-1 [26]HDAC2NucleusH3K9ac, H4K12ac [27]p53 (K320ac) [28], Nrf2 [29], Bcl-6, STAT3 [30]HDAC3Nucleus
CytoplasmH3K9ac, H3K14ac, H4K5ac, H4K12ac [31]p65 (K310ac, K314ac, K315ac) [32], MEF2 [33], STAT1, STAT3 [34], GATA1 [35]HDAC8Nucleus
CytoplasmH3K9ac, H3K14ac, H3K56ac [36]ARID1A (K1808ac) [37], cortactin [38]Class IIClass IIaHDAC4Nucleus p53, STAT1 [39], SRF [40], HIF-1α [41], ATF4 [40], FoxO1 [42]HDAC5Nucleus reelin [43]HDAC7Nucleus HIF-1α [44]HDAC9Nucleus Class IIbHDAC6CytoplasmH3K14ac, H4K5ac, H4K12ac, H4K16ac [45]G3BP1 (K376ac) [46], cortactin (K124ac) [47], Hsp90 (K294ac) [48], β-Catenin [49], Prx I, Prx II [50], Survivin [51], AKT (K37ac, K163ac) [51]HDAC10Cytoplasm MSH2 [52], MMP2, MMP9 [53], Hsp70 [24]Class IIISITR1NucleusH3K9ac, H3K14ac, H3K56ac, H4K16ac [54]BMAL1 [55], TGF-β [56], PGC-1α [57], p53 (K379ac) [58]SIRT2Nucleus
CytoplasmH3K56ac, H4K16ac [54]G6PD [38], α-tubulin [59]SIRT3Nucleus
MitochondriaH4K16ac [54], H3K4bhb, H3K9bhb, H3K18bhb, H3K23bhb, H3K27bhb, H4K16bhb [60], H3K4cr [61]ACSS1 (K642ac) [62], SDHA (K179ac) [63]SIRT4Mitochondria MCCC [64], MCD [65]SIRT5Mitochondria PKM2 (K311ac) [66], CPS1 [67]SIRT6Nucleus
Endoplasmic Reticulum
MitochondriaH3K9ac,
H3K56ac [68]TNF (K19ac, K20ac) [69]SIRT7Nucleus
CytoplasmH3K18ac [70]FKBP51 (K28ac, K155ac) [71], Ran (K37ac) [72], U3-55k (K12ac, K25ac) [73], nucleophosmin (K27ac, K54ac) [74]Class IVHDAC11Nucleus IL-10 [75]HATsGNATGCN5 (KAT2A)NucleusH3K9 [76]PLK4 (K45, K46) [77], ISWI (K753) [78], SNF2 (K1493, K1497) [79], TBX5 [77]PCAF (KAT2B)NucleusH3K9 [76]ISX (K69) [80], IDH2 (K180) [81]HAT1 (KAT1)Nucleus
Cytoplasm
MitochondriaH4K5, H4K12 [45]TPR (K531) [82]ELP3Nucleus
Cytoplasm Bruchpilot [83]HPA2Cytoplasm Polyamines, small basic proteins [84]HPA3Cytoplasm Polyamines, D-amino acids [84]MYSTTip60 (KAT5)Nucleus
CytoplasmH2AK5, H2AK15, H3K14, H4K5, H4K8, H4K12, H4K16 [76]BMAL1 (K538) [85], ATM (K3016) [86], Ran, Pacer [87]MOZ (KAT6A)NucleusH3K9, H3K14, H3K23 [76]p53 (K120, K382) [88], BRPF1 [89]MORF (KAT6B)NucleusH3K14, H3K23 [76]BRPF1 [89], Runx2 [90]HBO1 (KAT7)NucleusH3K9, H3K14, H4K5, H4K8, H4K12 [76]CDT1 [91]MOF (KAT8)Nucleus
MitochondriaH4K5, H4K8, H4K16 [92]Lamin A/C (K311) [93]SAS2Nucleus SAS3Nucleus ESA1Nucleus Atg3 [94]p300/CBPp300 (KAT3B)Nucleus
CytoplasmH2AK4, H2AK5, H2AK7, H2AK9, H2AK11, H2AK13, H2BK5, H2BK11, H2BK12, H2BK15, H2BK16, H2BK20, H2BK21, H2BK23, H2BK24, H3K18, H3K27, H3K36, H4K5 [95]Sam68, hnRNP M [96], Snail, Smad4, PCNA [97], FoxO1 [98], GATA1 [99], NCOA1, NCOA2, NCOA3, ARNT, ARNT2 [95]CBP (KAT3A)Nucleus
CytoplasmH2AK4, H2AK5, H2AK7, H2AK9, H2AK11, H2AK13, H2BK5, H2BK11, H2BK12, H2BK15, H2BK16, H2BK20, H2BK21, H2BK23, H2BK24, H3K18, H3K27, H3K36, H4K5 [95]TPX2 (K75, K476, and K582) [100], GATA1 [101], NCOA1, NCOA2, NCOA3, ARNT, ARNT2 [95], Snail, FoxO1, PCNA [102]TAFII230/250TAFII250Nucleus TAF1OthersATAT1Nucleus
Cytoplasm α-Tubulin (K40) [103]ESCO1Nucleus
Cytoplasm SMC3 (K105, K106) [104]ESCO2Nucleus
Cytoplasm SMC3 (K105, K106) [104]CLOCK (KAT13D)Nucleus
Cytoplasm ASS1 (K165, K176) [105]ATAC2 (KAT14)Nucleus
CytoplasmH3K9, H4K5, H4K12, H4K16 [106]