aSevere Asthma and Rare Lung Disease Unit, San Luigi Gonzaga University Hospital, Orbassano

bDepartment of Clinical and Biological Sciences, University of Turin, Turin

cIRCCS Humanitas Research Hospital

dHumanitas University, Milan

eInstitute of Translational Pharmacology, National Research Council (IFT-CNR), section of Palermo, Italy

Correspondence to Giuseppe Guida, PhD, MD, San Luigi Gonzaga University Hospital, Orbassano, Regione Gonzole, 10, Turin, TO 10043, Italy. Tel: +39 119026777; e-mail: [email protected]