Andriessen EM, Wilson AM, Mawambo G, Dejda A, Miloudi K, Sennlaub F, Sapieha P (2016) Gut microbiota influences pathological angiogenesis in obesity-driven choroidal neovascularization. EMBO Mol Med 8:1366–1379. https://doi.org/10.15252/emmm.201606531
Beli E, Yan Y, Moldovan L, Vieira CP, Gao R, Duan Y, Prasad R, Bhatwadekar A, White FA, Townsend SD, Chan L, Ryan CN, Morton D, Moldovan EG, Chu FI, Oudit GY, Derendorf H, Adorini L, Wang XX, Evans-Molina C, Mirmira RG, Boulton ME, Yoder MC, Li Q, Levi M, Busik JV, Grant MB (2018) Restructuring of the gut microbiome by intermittent fasting prevents retinopathy and prolongs survival in db/db mice. Diabetes 67:1867–1879. https://doi.org/10.2337/db18-0158
Benjamini Y, Yekutieli D (2001) The control of the false discovery rate in multiple testing under dependency. Anna Stat 29:1165–1188
Bosák J, Lexa M, Fiedorová K, Gadara DC, Micenková L, Spacil Z, Litzman J, Freiberger T, Šmajs D (2021) Patients with common variable immunodeficiency (CVID) show higher gut bacterial diversity and levels of low-abundance genes than the healthy housemates. Front Immunol 12:671239. https://doi.org/10.3389/fimmu.2021.671239
Bowden J, Davey Smith G, Haycock PC, Burgess S (2016a) Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol 40:304–314. https://doi.org/10.1002/gepi.21965
Bowden J, Del Greco MF, Minelli C, Davey Smith G, Sheehan NA, Thompson JR (2016b) Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic. Int J Epidemiol 45:1961–1974. https://doi.org/10.1093/ije/dyw220
Burgess S, Scott RA, Timpson NJ, Davey Smith G, Thompson SG (2015) Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors. Eur J Epidemiol 30:543–552. https://doi.org/10.1007/s10654-015-0011-z
Cattaneo A, Cattane N, Galluzzi S, Provasi S, Lopizzo N, Festari C, Ferrari C, Guerra UP, Paghera B, Muscio C, Bianchetti A, Volta GD, Turla M, Cotelli MS, Gennuso M, Prelle A, Zanetti O, Lussignoli G, Mirabile D, Bellandi D, Gentile S, Belotti G, Villani D, Harach T, Bolmont T, Padovani A, Boccardi M, Frisoni GB (2017) Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. Neurobiol Aging 49:60–68. https://doi.org/10.1016/j.neurobiolaging.2016.08.019
Cui C, Tan S, Tao L, Gong J, Chang Y, Wang Y, Fan P, He D, Ruan Y, Qiu W (2020) intestinal barrier breakdown and mucosal microbiota disturbance in neuromyelitis optical spectrum disorders. Front Immunol 11:2101. https://doi.org/10.3389/fimmu.2020.02101
Davey Smith G, Hemani G (2014) Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet 23:R89-98. https://doi.org/10.1093/hmg/ddu328
Donaldson GP, Ladinsky MS, Yu KB, Sanders JG, Yoo BB, Chou WC, Conner ME, Earl AM, Knight R, Bjorkman PJ, Mazmanian SK (2018) Gut microbiota utilize immunoglobulin A for mucosal colonization. Science 360:795–800. https://doi.org/10.1126/science.aaq0926
Fernandes R, Viana SD, Nunes S, Reis F (2019) Diabetic gut microbiota dysbiosis as an inflammaging and immunosenescence condition that fosters progression of retinopathy and nephropathy. Biochim Biophys Acta Mol Basis Dis 1865:1876–1897. https://doi.org/10.1016/j.bbadis.2018.09.032
FinnGen (2022) FinnGen Documentation of the R7 release. (https://r7.finngen.fi/). https://doi.org/10.1016/s0161-6420(90)32428-4
Ghezzi L, Cantoni C, Pinget GV, Zhou Y, Piccio L (2021) Targeting the gut to treat multiple sclerosis. J Clin Invest. https://doi.org/10.1172/jci143774
Goodrich JK, Davenport ER, Beaumont M, Jackson MA, Knight R, Ober C, Spector TD, Bell JT, Clark AG, Ley RE (2016) Genetic determinants of the gut microbiome in UK twins. Cell Host Microbe 19:731–743. https://doi.org/10.1016/j.chom.2016.04.017
Hartwig FP, Davey Smith G, Bowden J (2017) Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption. Int J Epidemiol 46:1985–1998. https://doi.org/10.1093/ije/dyx102
Hemani G, Tilling K, Davey Smith G (2017) Orienting the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genet 13:e1007081. https://doi.org/10.1371/journal.pgen.1007081
Hu X, Du J, Xie Y, Huang Q, Xiao Y, Chen J, Yan S, Gong Z, Ouyang S (2020) Fecal microbiota characteristics of Chinese patients with primary IgA nephropathy: a cross-sectional study. BMC Nephrol 21:97. https://doi.org/10.1186/s12882-020-01741-9
Jiang L, Zheng Z, Fang H, Yang J (2021) A generalized linear mixed model association tool for biobank-scale data. Nat Genet 53:1616–1621. https://doi.org/10.1038/s41588-021-00954-4
Jiang Z, Zhuo LB, He Y, Fu Y, Shen L, Xu F, Gou W, Miao Z, Shuai M, Liang Y, Xiao C, Liang X, Tian Y, Wang J, Tang J, Deng K, Zhou H, Chen YM, Zheng JS (2022) The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases. Nat Commun 13:3002. https://doi.org/10.1038/s41467-022-30712-x
Kurilshikov A, Medina-Gomez C, Bacigalupe R, Radjabzadeh D, Wang J, Demirkan A, Le Roy CI, Raygoza Garay JA, Finnicum CT, Liu X, Zhernakova DV, Bonder MJ, Hansen TH, Frost F, Rühlemann MC, Turpin W, Moon JY, Kim HN, Lüll K, Barkan E, Shah SA, Fornage M, Szopinska-Tokov J, Wallen ZD, Borisevich D, Agreus L, Andreasson A, Bang C, Bedrani L, Bell JT, Bisgaard H, Boehnke M, Boomsma DI, Burk RD, Claringbould A, Croitoru K, Davies GE, van Duijn CM, Duijts L, Falony G, Fu J, van der Graaf A, Hansen T, Homuth G, Hughes DA, Ijzerman RG, Jackson MA, Jaddoe VWV, Joossens M, Jørgensen T, Keszthelyi D, Knight R, Laakso M, Laudes M, Launer LJ, Lieb W, Lusis AJ, Masclee AAM, Moll HA, Mujagic Z, Qibin Q, Rothschild D, Shin H, Sørensen SJ, Steves CJ, Thorsen J, Timpson NJ, Tito RY, Vieira-Silva S, Völker U, Völzke H, Võsa U, Wade KH, Walter S, Watanabe K, Weiss S, Weiss FU, Weissbrod O, Westra HJ, Willemsen G, Payami H, Jonkers D, Arias Vasquez A, de Geus EJC, Meyer KA, Stokholm J, Segal E, Org E, Wijmenga C, Kim HL, Kaplan RC, Spector TD, Uitterlinden AG, Rivadeneira F, Franke A, Lerch MM, Franke L, Sanna S, D’Amato M, Pedersen O et al (2021) Large-scale association analyses identify host factors influencing human gut microbiome composition. Nat Genet 53:156–165. https://doi.org/10.1038/s41588-020-00763-1
Lee JY, Han J, Yang M, Oh SY (2020) Population-based incidence of pediatric and adult optic neuritis and the risk of multiple sclerosis. Ophthalmology 127:417–425. https://doi.org/10.1016/j.ophtha.2019.09.032
Liu K, Zou J, Fan H, Hu H, You Z (2022) Causal effects of gut microbiota on diabetic retinopathy: a Mendelian randomization study. Front Immunol 13:930318. https://doi.org/10.3389/fimmu.2022.930318
Lu Q, Lai J, Lu H, Ng C, Huang T, Zhang H, Ding K, Wang Z, Jiang J, Hu J, Lu J, Lu S, Mou T, Wang D, Du Y, Xi C, Lyu H, Chen J, Xu Y, Liu Z, Hu S (2019) Gut microbiota in bipolar depression and its relationship to brain function: an advanced exploration. Front Psychiatry 10:784. https://doi.org/10.3389/fpsyt.2019.00784
Matsuya N, Komori M, Nomura K, Nakane S, Fukudome T, Goto H, Shiraishi H, Wandinger KP, Matsuo H, Kondo T (2011) Increased T-cell immunity against aquaporin-4 and proteolipid protein in neuromyelitis optica. Int Immunol 23:565–573. https://doi.org/10.1093/intimm/dxr056
Navarro-López V, Méndez-Miralles M, Vela-Yebra R, Fríes-Ramos A, Sánchez-Pellicer P, Ruzafa-Costas B, Núñez-Delegido E, Gómez-Gómez H, Chumillas-Lidón S, Picó-Monllor JA, Navarro-Moratalla L (2022) Gut microbiota as a potential predictive biomarker in relapsing-remitting multiple sclerosis. Genes. https://doi.org/10.3390/genes13050930
Pröbstel AK, Zhou X, Baumann R, Wischnewski S, Kutza M, Rojas OL, Sellrie K, Bischof A, Kim K, Ramesh A, Dandekar R, Greenfield AL, Schubert RD, Bisanz JE, Vistnes S, Khaleghi K, Landefeld J, Kirkish G, Liesche-Starnecker F, Ramaglia V, Singh S, Tran EB, Barba P, Zorn K, Oechtering J, Forsberg K, Shiow LR, Henry RG, Graves J, Cree BAC, Hauser SL, Kuhle J, Gelfand JM, Andersen PM, Schlegel J, Turnbaugh PJ, Seeberger PH, Gommerman JL, Wilson MR, Schirmer L, Baranzini SE (2020) Gut microbiota-specific IgA(+) B cells traffic to the CNS in active multiple sclerosis. Sci Immunol. https://doi.org/10.1126/sciimmunol.abc7191
Rowan S, Jiang S, Korem T, Szymanski J, Chang ML, Szelog J, Cassalman C, Dasuri K, McGuire C, Nagai R, Du XL, Brownlee M, Rabbani N, Thornalley PJ, Baleja JD, Deik AA, Pierce KA, Scott JM, Clish CB, Smith DE, Weinberger A, Avnit-Sagi T, Lotan-Pompan M, Segal E, Taylor A (2017) Involvement of a gut-retina axis in protection against dietary glycemia-induced age-related macular degeneration. Proc Natl Acad Sci U S A 114:E4472-e4481. https://doi.org/10.1073/pnas.1702302114
Soriano S, Curry K, Sadrameli SS, Wang Q, Nute M, Reeves E, Kabir R, Wiese J, Criswell A, Schodrof S, Britz GW, Gadhia R, Podell K, Treangen T, Villapol S (2022) Alterations to the gut microbiome after sport-related concussion in a collegiate football players cohort: a pilot study. Brain Behav Immun Health 21:100438. https://doi.org/10.1016/j.bbih.2022.100438
Thanassoulis G, O’Donnell CJ (2009) Mendelian randomization: nature’s randomized trial in the post-genome era. JAMA 301:2386–2388. https://doi.org/10.1001/jama.2009.812
Toosy AT, Mason DF, Miller DH (2014) Optic neuritis. Lancet Neurol 13:83–99. https://doi.org/10.1016/s1474-4422(13)70259-x
Varrin-Doyer M, Spencer CM, Schulze-Topphoff U, Nelson PA, Stroud RM, Cree BA, Zamvil SS (2012) Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter. Ann Neurol 72:53–64. https://doi.org/10.1002/ana.23651
Waters JL, Ley RE (2019) The human gut bacteria Christensenellaceae are widespread, heritable, and associated with health. BMC Biol 17:83. https://doi.org/10.1186/s12915-019-0699-4
Xiang K, Wang P, Xu Z, Hu YQ, He YS, Chen Y, Feng YT, Yin KJ, Huang JX, Wang J, Wu ZD, Yang XK, Wang DG, Ye DQ, Pan HF (2021) Causal effects of gut microbiome on systemic lupus erythematosus: a two-sample mendelian randomization study. Front Immunol 12:667097. https://doi.org/10.3389/fimmu.2021.667097
Xu Q, Ni JJ, Han BX, Yan SS, Wei XT, Feng GJ, Zhang H, Zhang L, Li B, Pei YF (2021) causal relationship between gut microbiota and autoimmune diseases: a two-sample mendelian randomization study. Front Immunol 12:746998. https://doi.org/10.3389/fimmu.2021.746998
Zamvil SS, Spencer CM, Baranzini SE, Cree BAC (2018) The gut microbiome in neuromyelitis optica. Neurotherapeutics 15:92–101. https://doi.org/10.1007/s13311-017-0594-z
Zhao F, Feng J, Li J, Zhao L, Liu Y, Chen H, Jin Y, Zhu B, Wei Y (2018) Alterations of the gut microbiota in hashimoto’s thyroiditis patients. Thyroid 28:175–186. https://doi.org/10.1089/thy.2017.0395
Zhao Q, Chen Y, Wang J, Small DS (2019) Powerful three-sample genome-wide design and robust statistical inference in summary-data Mendelian randomization. Int J Epidemiol 48:1478–1492. https://doi.org/10.1093/ije/dyz142
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