Current Oncology, Vol. 30, Pages 416-429: Gastrointestinal Stromal Tumours (GIST) of the Rectum: A Systematic Review and Meta-Analysis

Figure 1. (AD): Neoadjuvant vs. adjuvant chemotherapy meta-analysis outcomes. (A) Recurrence, (B) Five-year overall survival, (C) Five-year disease-free survival, (D) Negative margin (R0) rates.

Figure 1. (AD): Neoadjuvant vs. adjuvant chemotherapy meta-analysis outcomes. (A) Recurrence, (B) Five-year overall survival, (C) Five-year disease-free survival, (D) Negative margin (R0) rates.

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Figure 2. (AF): Local excision vs. radical excision meta-analysis results. (A) Recurrence, (B) Five-year Overall Survival, (C) Five-year Disease-free Survival, (D) Length of Stay, (E) Intraoperative Tumour Perforation, (F) R0 Rates.

Figure 2. (AF): Local excision vs. radical excision meta-analysis results. (A) Recurrence, (B) Five-year Overall Survival, (C) Five-year Disease-free Survival, (D) Length of Stay, (E) Intraoperative Tumour Perforation, (F) R0 Rates.

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Table 1. Methodological characteristics of the included studies.

Table 1. Methodological characteristics of the included studies.

Study NameJournalYear PublishedStudy PeriodType of StudyN of Rectal GISTs PatientsYong et al. [16]International Journal of Clinical Oncology2021 1996 to 2017Retrospective Cohort Study29Yang et al. [17]BMC Surgery2021 2002 to 2020Retrospective Cohort Study101Qin et al. [18]Annals of Translational Medicine2021 2008 to 2018Retrospective study17Liu et al. [19]Cancer Management and Research2021 2010 to 2019Retrospective Cohort Study21Ling et al. [20]Journal of Surgical Oncology2021 2007 to 2018Retrospective case–control study68 Emoto et al. [21]Journal of Gastrointestinal Surgery2021 2008 to 2017Retrospective Cohort Study20Bai et al. [22]Surgical Endoscopy2021 2006 to 2017Retrospective Cohort Study42Yang et al. [23]Annals of Translational Medicine2020 2008 to 2018Retrospective Cohort Study64Shu et al. [24]International Journal of Surgery2020 2004 to 2017Retrospective Cohort Study71Romain et al. [25]Journal of Surgical Oncology2020 2001 to 2013Retrospective Cohort Study35Ijzerman et al. [26]European Journal of Surgical Oncology2020 2009 to 2018Retrospective, multicentre, international cohort study155 total surgery/ 109 with data analysisGuo et al. [27]International Journal of Surgery2020 2008 to 2019Retrospective Cohort Study64Stuart et al. [28]Journal of Surgical Oncology2019 1976 to 2017Retrospective review48Zhu et al. [29]Journal of Gastrointestinal Oncology2018 2006 to 2013Retrospective Cohort Study282Yasui et al. [30]Surgery Today2017 2003 to 2007Retrospective Cohort Study24Hawkins et al. [31]Annals of Surgical Oncology2017 1998 to 2012Retrospective Cohort Study321Cavnar et al. [32]Annals of Surgical Oncology2017 1982 to 2016Retrospective review47Zanwar et al. [33]Indian Journal of Gastroenterology2016 2005 to 2015Cohort Study18Wilkinson et al. [34] British Journal of Surgery2015 2001 to 2013Retrospective Cohort Study13Shen et al. [35]Neoplasma20152005 to 2014Retrospective Cohort Study45Liu et al. [1]Journal of Surgical Oncology2014 2002 to 2010Retrospective review21Huynh et al. [36]BMC Cancer2014 1991 to 2011Retrospective Cohort Study41Xiao et al. [37]Journal of Gastrointestinal Surgery2013 1986 to 2010Retrospective Cohort Study21Tielen et al. [5]Journal of Surgical Oncology2013 1990 to 2011Retrospective Cohort Study32Agaimy et al. [38]International Journal of Colorectal Disease2013 2000 and 2011Retrospective multicentre study15Dong et al. [39]Scandinavian Journal of Gastroenterology2007 1997 to 2005Retrospective Cohort Study29Hassan et al. [40]Diseases of the Colon and Rectum2006 1979 to 2004Retrospective Cohort Study14Changchien et al. [41]Diseases of the Colon and Rectum2004 1979 to 1999Retrospective Cohort Study42

Table 2. Summary of Surgical Detail.

Table 2. Summary of Surgical Detail.

Study NameTotal N PatientsTumour Size at Diagnosis (cm)-Mean Local ExcisionRadical ExcisionSurgical ApproachMargin StatusR0/%R1/%R2/%Yong et al. [16]29--29Transanal 7/29
Laparoscopic 2/29
Open 20/2915 of 29/51.7%10 of 29/34.5%-Yang et al. [17]1016.18 ± 3.02956Transanal 5/101
Laparoscopic 14/101
Open 82/10197 of 101/96%4 of 101/4%Qin et al. [18]176.4 ± 2.2-17-17 of 17/100%0 of 17/0%Liu et al. [19]214.96 ± 3.02156-16 of 21/76.2%5 of 21/23.8%-Ling et al. [20]68 -5014--Emoto et al. [21]206.5 ± 3416Transanal 4/20
Laparoscopic 15/20
Open 1/2017 of 20/85%3 of 20/15%Bai et al. [22]422.87 ± 1.6142-Transanal 42/42
Laparoscopic 0/42
Open 0/4242 of 42/100%0 of 42/0%Yang et al. [23]64-2935Transanal 29/64
Laparoscopic N/a
Open N/a
Nontransanal 35/6463 of 64/98.4%1 of 64/1.6%Shu et al. [24]71-4229-56 of 71/78.9%15 of 71/21.2%0 of 71/0%Romain et al. [25]35-35Transanal 9/35
Laparoscopic 3/35
Open 23/3530 of 35/85.7%4 of 35/11.4%1 of 35/2.9%Ijzerman et al. [26]1096.5 ± 3.674663-67 of 109/61.5%31 of 109/28.4%10 of 109/9.2%Guo et al. [27]64-39 25 -63 of 64/98.4%1 of 64/1.6%Stuart et al. [28]48-48--Zhu et al. [29]282-144138-219 of 282/77.7%3 of 282/1.1%Yasui et al. [30]244.8 ± 2.38914Transanal 1/24
Laparoscopic 0/24
Open 23/2422 of 24/91.7%1 of 24/4.2%1 of 24/4.2%Hawkins et al. [31]3214.0 ± 0.8163158 -247 of 321/76.9%74 of 321/23.1%Cavnar et al. [32]47-2324-33 of 47/70.2%12 of 47/25.5%2 of 47/4.3%Zanwar et al. [33]186 ± 2.45414 -17 of 18/94.4%0 of 18/0%1 of 18/5.6%Wilkinson et al. [34] 137⋅6 ± 2.613-12 of 13/92.3%0 of 13/0%1 of 13/7.7%Shen et al. [35]456.0 ± 32124-43 of 45/95.6%2 of 45/4.4%0 of 45/0%Liu et al. [1]216.53 ± 2.45138-17 of 21/81%4 of 21/19%Huynh et al. [36]416.3 ± 3.11823-22 of 41/53.7%13 of 41/31.7%4 of 41/9.8%Xiao et al. [37]217.5 ± 6.41011-21 of 21/100%0 of 21/0%Tielen et al. [5]329.2 ± 12.75725Transanal 2/32
Laparoscopic N/a
Open N/a
Nontransanal 30/3224 of 32/75%6 of 32/18.8%2 of 32/6.3%Agaimy et al. [38]154.8 ± 2.1778-6 of 15/40%2 of 15/13.3%6 of 15/40%Dong et al. [39]295.0 ± 4.41415Transanal 14/29
Laparoscopic 0/29
Open 15/2929 of 29/100%0 of 29/0%Hassan et al. [40]14-59Transanal 4/14
Laparoscopic 0/14
Open 10/1414 of 14/100%0 of 14/0%Changchien et al. [41]42-1329--

Table 3. Summary of Chemotherapy Details.

Table 3. Summary of Chemotherapy Details.

Study NameNeo-Adjuvant TherapyAdjuvant Therapy No. Patients TypeDuration (Median (Month)) (Range)No. Patients TypeDuration (Median (Month)) (Range)Yong et al. [16]11/36Imatinib8.8 (4.5–33.9)---Yang et al. [17]31/101Imatinib-49/101Imatinib-Qin et al. [18]15/17Imatinib-14/17Imatinib1 (1–8)Liu et al. [19]21/36Imatinib17 10/21Imatinib17 Ling et al. [20]52/85Imatinib6.9 (1.0–58.9)40/68Imatinib-Emoto et al. [21]16/20Imatinib7 (4–11)11/20Imatinib35 (11–108)Bai et al. [22]16/42Imatinib6 15/42Imatinib18 (7–36)Yang et al. [23]29/64Imatinib-30/64Imatinib-Shu et al. [24]23/71Imatinib7.0 (6–12)21/71Imatinib-Romain et al. [25]22/35Imatinib9 (4–14)21/35Imatinib-Ijzerman et al. [26]78/109Imatinib10 (1–102),70/109Imatinib25 (0–112).Guo et al. [27]29/64Imatinib-30/64Imatinib-Stuart et al. [28]8/48Imatinib-22/48Imatinib-Zhu et al. [29]------Yasui et al. [30]4/24 2.5 (1–6)3/24Imatinib-Hawkins et al. [31]86/321Imatinib-82/321Imatinib-Cavnar et al. [32]21/47Imatinib7.7 (3–62) 2212/47Imatinib2.8 (0.1–6.5)Zanwar et al. [33]16/23Imatinib15 (3–84)---Wilkinson et al. [34] 15/19Imatinib18 (11–44)7/19Imatinib-Shen et al. [35]3/45Imatinib-13/45Imatinib18 (3–46).Liu et al. [1]5/21Imatinib6 (6–8)8/21Imatinib-Huynh et al. [36]12/41Imatinib7 (2–12).11/41Imatinib7 (2–41)Xiao et al. [37]-Imatinib-4/21Imatinib -Tielen et al. [5]22/32Imatinib9 (2–53)9/32Imatinib-Agaimy et al. [38]4/15Imatinib (2/4)Sunitinib (1/4)Adriamycin + Holoxan (1/4)-9/15Imatinib-Dong et al. [39]------Hassan et al. [40]------Changchien et al. [41] -----

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