Extracellular vesicles in the glioblastoma microenvironment: A diagnostic and therapeutic perspective

Elsevier

Available online 27 December 2022, 101167

Molecular Aspects of MedicineAuthor links open overlay panelAbstract

Glioblastoma (GBM), is the most malignant form of gliomas and the most common and lethal primary brain tumor in adults. Conventional cancer treatments have limited to no efficacy on GBM. GBM cells respond and adapt to the surrounding brain parenchyma known as tumor microenvironment (TME) to promote tumor preservation. Among specific TME, there are 3 of particular interest for GBM biology: the perivascular niche, the subventricular zone neurogenic niche, and the immune microenvironment. GBM cells and TME cells present a reciprocal feedback which results in tumor maintenance. One way that these cells can communicate is through extracellular vesicles. These vesicles include exosomes and microvesicles that have the ability to carry both cancerous and non-cancerous cargo, such as miRNA, RNA, proteins, lipids, and DNA. In this review we will discuss the booming topic that is extracellular vesicles, and how they have the novelty to be a diagnostic and targetable vehicle for GBM.

Keywords

Glioblastoma multiforme

Tumor microenvironment

Perivascular niche

Subventricular zone/neurogenic niche

Exosomes

Microvesicles

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© 2022 Published by Elsevier Ltd.

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