Long-term Consequences of COVID-19: Chemosensory Disorders

Nalbandian A, Sehgal K, Gupta A, et al. Post-acute COVID-19 syndrome. Nat Med. 2021;27(4):601–15.

Article  Google Scholar 

Groff D, Sun A, Ssentongo AE, et al. Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection: a systematic review. JAMA Netw Open. 2021;4(10): e2128568.

Article  Google Scholar 

Healey Q, Sheikh A, Daines L, Vasileiou E. Symptoms and signs of long COVID: a rapid review and meta-analysis. J Glob Health. 2022;12:05014.

Article  Google Scholar 

Yang T, Yan MZ, Li X, Lau EHY. Sequelae of COVID-19 among previously hospitalized patients up to 1 year after discharge: a systematic review and meta-analysis. Infection. 2022.

Lechien JR, Chiesa-Estomba CM, De Siati DR, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol. 2020;277(8):2251–61.

Article  Google Scholar 

Spinato G, Fabbris C, Polesel J, et al. Alterations in smell or taste in mildly symptomatic outpatients with SARS-CoV-2 infection. JAMA. 2020;323(20):2089–90.

Article  Google Scholar 

Rojas-Lechuga MJ, Izquierdo-Dominguez A, Chiesa-Estomba C, et al. Chemosensory dysfunction in COVID-19 out-patients. Eur Arch Otorhinolaryngol. 2021;278(3):695–702.

Article  Google Scholar 

Zeng M, Wang DY, Mullol J, Liu Z. Chemosensory dysfunction in patients with COVID-19: what do we learn from the global outbreak? Curr Allergy Asthma Rep. 2021;21(2):6.

Article  Google Scholar 

Nouchi A, Chastang J, Miyara M, et al. Prevalence of hyposmia and hypogeusia in 390 COVID-19 hospitalized patients and outpatients: a cross-sectional study. Eur J Clin Microbiol Infect Dis. 2021;40(4):691–7.

Article  Google Scholar 

Yan C, Faraji F, Prajapati DP, Boone CE, DeConde AS. Association of chemosensory dysfunction and Covid-19 in patients presenting with influenza-like symptoms. Int Forum Allergy Rhinol. 2020;10(7):806–813.

Boscolo-Rizzo P, Borsetto D, Fabbris C, et al. Evolution of altered sense of smell or taste in patients with mildly symptomatic COVID-19. JAMA Otolaryngol Head Neck Surg. 2020;146(8):729–32.

Article  Google Scholar 

Ramasamy K, Saniasiaya J, Abdul GN. Olfactory and gustatory dysfunctions as a clinical manifestation of Coronavirus disease 2019 in a Malaysian Tertiary Center. Annals of Otology, Rhinology & Laryngology. 2020;130(5):513–9.

Article  Google Scholar 

Song J, Deng YK, Wang H, et al. Self-reported taste and smell disorders in patients with COVID-19: distinct features in China. Curr Med Sci. 2021;41(1):14–23.

Article  Google Scholar 

Paderno A, Mattavelli D, Rampinelli V, et al. Olfactory and gustatory outcomes in COVID-19: a prospective evaluation in nonhospitalized subjects. Otolaryngol Head Neck Surg. 2020;163(6):1144–9.

Article  Google Scholar 

•• Tan BKJ, Han R, Zhao JJ, et al. Prognosis and persistence of smell and taste dysfunction in patients with covid-19: meta-analysis with parametric cure modelling of recovery curves. BMJ. 2022;378:e069503. This meta-analysis reported that 5.6% and 4.4% of patients might develop long lasting self-reported OD and GD at 6 months post-covid-19. Women, greater initial severity of dysfunction and nasal congestion were risk factors for poor recovery of chemosensory dysfunctions.

Nguyen NN, Hoang VT, Lagier JC, Raoult D, Gautret P. Long-term persistence of olfactory and gustatory disorders in COVID-19 patients. Clin Microbiol Infect. 2021;27(6):931–2.

Article  Google Scholar 

Biadsee A, Dagan O, Ormianer Z, Kassem F, Masarwa S, Biadsee A. Eight-month follow-up of olfactory and gustatory dysfunctions in recovered COVID-19 patients. Am J Otolaryngol. 2021;42(4): 103065.

Article  Google Scholar 

Hopkins C, Surda P, Vaira LA, et al. Six month follow-up of self-reported loss of smell during the COVID-19 pandemic. Rhinology. 2021;59(1):26–31.

Google Scholar 

Coelho DH, Reiter ER, Budd SG, Shin Y, Kons ZA, Costanzo RM. Quality of life and safety impact of COVID-19 associated smell and taste disturbances. Am J Otolaryngol. 2021;42(4): 103001.

Article  Google Scholar 

Reis D, Sartoretto SC, Calasans-Maia MD, Louro RS, Moraschini V. Long-term prevalence of taste and olfactory dysfunction in COVID-19 patients: a cross-sectional study. Oral Dis. 2022.

Teaima AA, Salem OM, Teama M, et al. Patterns and clinical outcomes of olfactory and gustatory disorders in six months: prospective study of 1031 COVID-19 patients. Am J Otolaryngol. 2022;43(1):103259.

Boscolo-Rizzo P, Menegaldo A, Fabbris C, et al. Six-Month Psychophysical evaluation of olfactory dysfunction in patients with COVID-19. Chem Senses. 2021;46.

Mazzatenta A, Neri G, D'Ardes D, et al. Smell and taste in severe CoViD-19: self-reported vs. testing. Front Med (Lausanne). 2020;7:589409.

Hintschich CA, Fischer R, Hummel T, Wenzel JJ, Bohr C, Vielsmeier V. Persisting olfactory dysfunction in post-COVID-19 is associated with gustatory impairment: results from chemosensitive testing eight months after the acute infection. PLoS ONE. 2022;17(3): e0265686.

Article  Google Scholar 

Bussiere N, Mei J, Levesque-Boissonneault C, et al. Chemosensory dysfunctions induced by COVID-19 can persist up to 7 months: a study of over 700 healthcare workers. Chem Senses. 2021;46.

Petrocelli M, Cutrupi S, Salzano G, et al. Six-month smell and taste recovery rates in coronavirus disease 2019 patients: a prospective psychophysical study. J Laryngol Otol. 2021;135(5):436–41.

Article  Google Scholar 

Cristillo V, Pilotto A, Cotti Piccinelli S, et al. Age and subtle cognitive impairment are associated with long-term olfactory dysfunction after COVID-19 infection. J Am Geriatr Soc. 2021;69(10):2778–80.

Article  Google Scholar 

Prem B, Liu DT, Besser G, et al. Long-lasting olfactory dysfunction in COVID-19 patients. Eur Arch Otorhinolaryngol. 2022;279(7):3485–92.

Article  Google Scholar 

• Bordin A, Mucignat-Caretta C, Gaudioso P, et al. Comparison of self-reported symptoms and psychophysical tests in coronavirus disease 2019 (COVID-19) subjects experiencing long-term olfactory dysfunction: a 6-month follow-up study. Int Forum Allergy Rhinol. 2021;11(11):1592–1595. This study compared the results of self-reported symptoms and psychophysical tests in COVID-19 patients with long-term OD at 6-month follow-up. The results confirmed that psychophysical smell tests were more sensitive than patient-reported outcome measures, and that the latter could be unreliable when used to assess smell recovery in the long-term.

Fortunato F, Martinelli D, Iannelli G, et al. Self-reported olfactory and gustatory dysfunctions in COVID-19 patients: a 1-year follow-up study in Foggia district, Italy. BMC Infect Dis. 2022;22(1):77.

Article  Google Scholar 

Tan HQM, Pendolino AL, Andrews PJ, Choi D. Prevalence of olfactory dysfunction and quality of life in hospitalised patients 1 year after SARS-CoV-2 infection: a cohort study. BMJ Open. 2022;12(1): e054598.

Article  Google Scholar 

Fernandez-de-Las-Penas C, Martin-Guerrero JD, Navarro-Pardo E, Cancela-Cilleruelo I, Moro-Lopez-Menchero P, Pellicer-Valero OJ. Exploring trajectory curves from loss of smell and taste in previously hospitalized COVID-19 survivors: the LONG-COVID-EXP-CM Multicenter Study. J Gen Intern Med. 2022;37(7):1821–3.

Article  Google Scholar 

Ferreli F, Gaino F, Russo E, et al. Long-term olfactory dysfunction in COVID-19 patients: 18-month follow-up study. Int Forum Allergy Rhinol. 2022;12(8):1078–80.

Article  Google Scholar 

Boscolo-Rizzo P, Hummel T, Hopkins C, et al. High prevalence of long-term olfactory, gustatory, and chemesthesis dysfunction in post-COVID-19 patients: a matched case-control study with one-year follow-up using a comprehensive psychophysical evaluation. Rhinology. 2021;59(6):517–27.

Google Scholar 

• Boscolo-Rizzo P, Fabbris C, Polesel J, et al. Two-Year Prevalence and recovery rate of altered sense of smell or taste in patients with mildly symptomatic COVID-19. JAMA Otolaryngol Head Neck Surg. 2022;148(9):889–891. This 2 years follow-up study reported that 88.2% of patients reporting a COVID-19–related OD or GD completely recovered within 2 years. A late recovery was observed in 10.9% of patients.

Klein H, Asseo K, Karni N, et al. Onset, duration and unresolved symptoms, including smell and taste changes, in mild COVID-19 infection: a cohort study in Israeli patients. Clin Microbiol Infect. 2021.

Hummel T, Whitcroft KL, Andrews P, et al. Position paper on olfactory dysfunction. Rhinol Suppl. 2017;54(26):1–30.

Article  Google Scholar 

Riestra-Ayora J, Yanes-Diaz J, Esteban-Sanchez J, et al. Long-term follow-up of olfactory and gustatory dysfunction in COVID-19: 6 months case-control study of health workers. Eur Arch Otorhinolaryngol. 2021;278(12):4831–7.

Article  Google Scholar 

Cardoso CC, Rossi AD, Galliez RM, Faffe DS, Tanuri A, Castineiras T. Olfactory dysfunction in patients with mild COVID-19 during Gamma, Delta, and Omicron Waves in Rio de Janeiro. Brazil JAMA. 2022;328(6):582–3.

Article  Google Scholar 

Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271–280 e278.

Lechien JR, Radulesco T, Calvo-Henriquez C, et al. ACE2 & TMPRSS2 Expressions in head & neck tissues: a systematic review. Head Neck Pathol. 2020;15(1):225–35.

Article  Google Scholar 

Sungnak W, Huang N, Becavin C, et al. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med. 2020;26(5):681–7.

Article  Google Scholar 

Lu Y, Li X, Geng D, et al. Cerebral micro-structural changes in COVID-19 patients - an MRI-based 3-month follow-up study. EClinicalMedicine. 2020;25: 100484.

Article  Google Scholar 

Lee JC, Nallani R, Cass L, Bhalla V, Chiu AG, Villwock JA. A systematic review of the neuropathologic findings of post-viral olfactory dysfunction: implications and novel insight for the COVID-19 pandemic. Am J Rhinol Allergy. 2021;35(3):323–33.

Article  Google Scholar 

Kollndorfer K, Jakab A, Mueller CA, Trattnig S, Schopf V. Effects of chronic peripheral olfactory loss on functional brain networks. Neuroscience. 2015;310:589–99.

Article  Google Scholar 

Hosseini S, Wilk E, Michaelsen-Preusse K, et al. Long-term neuroinflammation induced by influenza a virus infection and the impact on hippocampal neuron morphology and function. J Neurosci. 2018;38(12):3060–80.

Article  Google Scholar 

Espinoza JA, Bohmwald K, Cespedes PF, et al. Impaired learning resulting from respiratory syncytial virus infection. Proc Natl Acad Sci U S A. 2013;110(22):9112–7.

Article  Google Scholar 

Glass WG, Subbarao K, Murphy B, Murphy PM. Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice. J Immunol. 2004;15(173(6)).

Li K, Wohlford-Lenane C, Perlman S, et al. Middle East respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4. J Infect Dis. 2016;213(5):712–22.

Article  Google Scholar 

Talbot PJ, Ekandé S, Cashman NR, Mounir S, Stewart JN. Neurotropism of human coronavirus 229E. Adv Exp Med Biol. 1993;342.

Cecchini MP, Brozzetti L, Cardobi N, et al. Persistent chemosensory dysfunction in a young patient with mild COVID-19 with partial recovery 15 months after the onset. Neurol Sci. 2022;43(1):99–104.

Article  Google Scholar 

Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol. 2020;92(6):552–5.

Article  Google Scholar 

Khan M, Yoo S-J, Clijsters M, et al. Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb. Cell. 2021;184(24):5932–49.

Article  Google Scholar 

Sun B, Tang N, Peluso MJ, et al. Characterization and biomarker analyses of post-COVID-19 complications and neurological manifestations. Cells. 2021;10(2).

Whitcroft KL, Hummel T. Clinical diagnosis and current management strategies for olfactory dysfunction: a review. JAMA Otolaryngol Head Neck Surg. 2019;145(9):846–53.

Article  Google Scholar 

Seo BS, Lee HJ, Mo J-H, Lee CH, Rhee CS, Kim J-W. Treatment of postviral olfactory loss with glucocorticoids, Ginkgo biloba, and mometasone nasal spray. Arch Otolaryngol Head Neck Surg. 2009;135(10):1000–1004.

Schriever VA, Merkonidis C, Gupta N, Hummel C, Hummel T. Treatment of smell loss with systemic methylprednisolone. Rhinology. 2012;50(3):284–9.

Article  Google Scholar 

Kim DH, Kim SW, Hwang SH, et al. Prognosis of olfactory dysfunction according to etiology and timing of treatment. Otolaryngol Head Neck Surg. 2017;156(2):371–7.

Article  Google Scholar 

Singh CV, Jain S, Parveen S. The outcome of fluticasone nasal spray on anosmia and triamcinolone oral paste in dysgeusia in COVID-19 patients. Am J Otolaryngol. 2021;42(3): 102892.

Article  Google Scholar 

Abdelalim AA, Mohamady AA, Elsayed RA, Elawady MA, Ghallab AF. Corticosteroid nasal spray for recovery of smell sensation in COVID-19 patients: a randomized controlled trial. Am J Otolaryngol. 2021;42(2): 102884.

Article  Google Scholar 

Le Bon SD, Konopnicki D, Pisarski N, Prunier L, Lechien JR, Horoi M. Efficacy and safety of oral corticosteroids and olfactory training in the management of COVID-19-related loss of smell. Eur Arch Otorhinolaryngol. 2021;278(8):3113–7.

Article 

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