The two sRNAs OmrA and OmrB indirectly repress transcription from the LEE1 promoter of enteropathogenic Escherichia coli

Bak G, Lee J, Suk S et al (2015) Identification of novel sRNAs involved in biofilm formation, motility, and fimbriae formation in Escherichia coli. Sci Rep 5:15287

Article  CAS  Google Scholar 

Barba J, Bustamante VH, Flores-Valdez MA et al (2005) A positive regulatory loop controls expression of the locus of enterocyte effacement-encoded regulators Ler and GrlA. J Bacteriol 187:7918–7930

Article  CAS  Google Scholar 

Bhatt S, Edwards AN, Nguyen HT et al (2009) The RNA binding protein CsrA is a pleiotropic regulator of the locus of enterocyte effacement pathogenicity island of enteropathogenic Escherichia coli. Infect Immun 77:3552–3568

Article  CAS  Google Scholar 

Bhatt S, Romeo T, Kalman D (2011) Honing the message: post-transcriptional and post-translational control in attaching and effacing pathogens. Trends Microbiol 19:217–224

Article  CAS  Google Scholar 

Bhatt S, Egan M, Jenkins V et al (2016) The tip of the iceberg: on the roles of regulatory small RNAs in the virulence of enterohemorrhagic and enteropathogenic Escherichia coli. Front Cell Infect Microbiol 6:1–6

Article  Google Scholar 

Bhatt S, Egan M, Ramirez J et al (2017a) Hfq and three Hfq-dependent small regulatory RNAs-MgrR, RyhB and McaS-coregulate the locus of enterocyte effacement in enteropathogenic Escherichia coli. Pathog Dis 75:1–14

Article  Google Scholar 

Bhatt S, Jenkins V, Mason E et al (2017b) The small regulatory RNA Spot42 inhibits indole biosynthesis to negatively regulate the locus of enterocyte effacement of enteropathogenic Escherichia coli. Microorganisms 5:1–12

Article  Google Scholar 

Brosse A, Korobeinikova A, Gottesman S et al (2016) Unexpected properties of sRNA promoters allow feedback control via regulation of a two-component system. Nucleic Acids Res 44:9650–9666

CAS  Google Scholar 

Bustamante VH, Santana FJ, Calva E et al (2001) Transcriptional regulation of type III secretion genes in enteropathogenic Escherichia coli: Ler antagonizes H-NS-dependent repression. Mol Microbiol 39:664–678

Article  CAS  Google Scholar 

Bustamante VH, Villalba MI, Garcia-Angulo VA et al (2011) PerC and GrlA independently regulate Ler expression in enteropathogenic Escherichia coli. Mol Microbiol 82:398–415

Article  CAS  Google Scholar 

Croxen MA, Finlay BB (2010) Molecular mechanisms of Escherichia coli pathogenicity. Nat Rev Microbiol 8:26–38

Article  CAS  Google Scholar 

Datta S, Costantino N, Court DL (2006) A set of recombineering plasmids for gram-negative bacteria. Gene 379:109–115

Article  CAS  Google Scholar 

De Lay N, Gottesman S (2012) A complex network of small non-coding RNAs regulate motility in Escherichia coli. Mol Microbiol 86:524–538

Article  Google Scholar 

De Lay N, Schu DJ, Gottesman S (2013) Bacterial small RNA-based negative regulation: Hfq and its accomplices. J Biol Chem 288:7996–8003

Article  Google Scholar 

Deng W, Puente JL, Gruenheid S et al (2004) Dissecting virulence: systematic and functional analyses of a pathogenicity island. Proc Natl Acad Sci USA 101:3597–3602

Article  CAS  Google Scholar 

Elliott SJ, Wainwright LA, McDaniel TK et al (1998) The complete sequence of the locus of enterocyte effacement (LEE) from enteropathogenic Escherichia coli E2348/69. Mol Microbiol 28:1–4

Article  CAS  Google Scholar 

Friedberg D, Umanski T, Fang Y et al (1999) Hierarchy in the expression of the locus of enterocyte effacement genes of enteropathogenic Escherichia coli. Mol Microbiol 34:941–952

Article  CAS  Google Scholar 

Gomez-Duarte OG, Kaper JB (1995) A plasmid-encoded regulatory region activates chromosomal eaeA expression in enteropathogenic Escherichia coli. Infect Immun 63:1767–1776

Article  CAS  Google Scholar 

Guillier M, Gottesman S (2006) Remodelling of the Escherichia coli outer membrane by two small regulatory RNAs. Mol Microbiol 59:231–247

Article  CAS  Google Scholar 

Guillier M, Gottesman S, Storz G (2006) Modulating the outer membrane with small RNAs. Genes Dev 20:2338–2348

Article  CAS  Google Scholar 

Guillier M, Gottesman S (2008) The 5′ end of two redundant sRNAs is involved in the regulation of multiple targets, including their own regulator. Nucleic Acids Res 36:6781–6794

Article  CAS  Google Scholar 

Hanahan D (1983) Studies on transformation of Escherichia coli with plasmids. J Mol Biol 166:557–580

Article  CAS  Google Scholar 

Hansen AM, Kaper JB (2009) Hfq affects the expression of the LEE pathogenicity island in enterohaemorrhagic Escherichia coli. Mol Microbiol 73:446–465

Article  CAS  Google Scholar 

Holmqvist E, Reimegard J, Sterk M et al (2010) Two antisense RNAs target the transcriptional regulator CsgD to inhibit curli synthesis. EMBO J 29:1840–1850

Article  CAS  Google Scholar 

Hu J, Torres AG (2015) Enteropathogenic Escherichia coli: foe or innocent bystander? Clin Microbiol Infect 21:729–734

Article  CAS  Google Scholar 

Huang LH, Syu WJ (2008) GrlA of enterohemorrhagic Escherichia coli O157:H7 activates LEE1 by binding to the promoter region. J Microbiol Immunol Infect 41:9–16

CAS  Google Scholar 

Iguchi A, Thomson NR, Ogura Y et al (2009) Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348/69. J Bacteriol 191:347–354

Article  CAS  Google Scholar 

Jarvis KG, Giron JA, Jerse AE et al (1995) Enteropathogenic Escherichia coli contains a putative type III secretion system necessary for the export of proteins involved in attaching and effacing lesion formation. Proc Natl Acad Sci USA 92:7996–8000

Article  CAS  Google Scholar 

Jobichen C, Li M, Yerushalmi G et al (2007) Structure of GrlR and the implication of its EDED motif in mediating the regulation of type III secretion system in EHEC. PLoS Pathog 3:e69

Article  Google Scholar 

Lanata CF, Fischer-Walker CL, Olascoaga AC et al (2013) Global causes of diarrheal disease mortality in children < 5 years of age: a systematic review. PLoS ONE 8:e72788

Article  CAS  Google Scholar 

Lenz DH, Mok KC, Lilley BN et al (2004) The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae. Cell 118:69–82

Article  CAS  Google Scholar 

Link TM, Valentin-Hansen P, Brennan RG (2009) Structure of Escherichia coli Hfq bound to polyriboadenylate RNA. Proc Natl Acad Sci USA 106:19292–19297

Article  CAS  Google Scholar 

Liu L, Johnson HL, Cousens S et al (2012) Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet 379:2151–2161

Article  Google Scholar 

Liu X, Matsumura P (1994) The FlhD/FlhC complex, a transcriptional activator of the Escherichia coli flagellar class II operons. J Bacteriol 176:7345–7351

Article  CAS  Google Scholar 

Mandin P, Gottesman S (2009) A genetic approach for finding small RNAs regulators of genes of interest identifies RybC as regulating the DpiA/DpiB two-component system. Mol Microbiol 72:551–565

Article  CAS  Google Scholar 

Melamed S, Faigenbaum-Romm R, Peer A et al (2018) Mapping the small RNA interactome in bacteria using RIL-seq. Nat Protoc 13:1–33

Article  CAS  Google Scholar 

Mellies JL, Elliott SJ, Sperandio V et al (1999) The Per regulon of enteropathogenic Escherichia coli : identification of a regulatory cascade and a novel transcriptional activator, the locus of enterocyte effacement (LEE)-encoded regulator (Ler). Mol Microbiol 33:296–306

Article  CAS  Google Scholar 

Mellies JL, Barron AM, Carmona AM (2007) Enteropathogenic and enterohemorrhagic Escherichia coli virulence gene regulation. Infect Immun 75:4199–4210

Article  CAS  Google Scholar 

Moller T, Franch T, Hojrup P et al (2002) Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction. Mol Cell 9:23–30

Article  CAS  Google Scholar 

Murphy KC, Campellone KG (2003) Lambda Red-mediated recombinogenic engineering of enterohemorrhagic and enteropathogenic E. coli. BMC Mol Biol 4:11

Padavannil A, Jobichen C, Mills E et al (2013) Structure of GrlR-GrlA complex that prevents GrlA activation of virulence genes. Nat Commun 4:2546

Article  Google Scholar 

Papenfort K, Vogel J (2010) Regulatory RNA in bacterial pathogens. Cell Host Microbe 8:116–127

Article  CAS  Google Scholar 

Platenkamp A, Mellies JL (2018) Environment controls LEE regulation in enteropathogenic Escherichia coli. Front Microbiol 9:1694

Article  Google Scholar 

Centers for Disease Control and Prevention-United Stated (CDC-US) (2015) Diarrhea: common illness, global killer. https://stacks.cdc.gov/view/cdc/13557#tabs-2. Accessed 7 Dec 2012

Romilly C, Hoekzema M, Holmqvist E et al (2020) Small RNAs OmrA and OmrB promote class III flagellar gene expression by inhibiting the synthesis of anti-Sigma factor FlgM. RNA Biol 17:872–880

Article  CAS  Google Scholar 

Sauder AB, Kendall MM (2021) A pathogen-specific sRNA influences enterohemorrhagic Escherichia coli fitness and virulence in part by direct interaction with the transcript encoding the ethanolamine utilization regulatory factor EutR. Nucleic Acids Res 49:10988–11004

Article  CAS  Google Scholar 

Serapio-Palacios A, Finlay BB (2020) Dynamics of expression, secretion and translocation of type III effectors during enteropathogenic Escherichia coli infection. Curr Opin Microbiol 54:67–76

Article  CAS  Google Scholar 

Shakhnovich EA, Davis BM, Waldor MK (2009) Hfq negatively regulates type III secretion in EHEC and several other pathogens. Mol Microbiol 74:347–363

留言 (0)

沒有登入
gif