Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial

Petersen RC, Lopez O, Armstrong MJ, Getchius TSD, Ganguli M, Gloss D, et al. Practice guideline update summary: mild cognitive impairment: report of the guideline development, dissemination, and implementation subcommittee of the American Academy of Neurology. Neurology. 2018;90(3):126–35. https://doi.org/10.1212/WNL.0000000000004826.

Article  Google Scholar 

Ward A, Tardiff S, Dye C, Arrighi HM. Rate of conversion from prodromal Alzheimer’s disease to Alzheimer’s dementia: a systematic review of the literature. Dement Geriatr Cogn Disord Extra. 2013;3(1):320–32. https://doi.org/10.1159/000354370.

Article  Google Scholar 

Mitchell AJ, Shiri-Feshki M. Rate of progression of mild cognitive impairment to dementia–meta-analysis of 41 robust inception cohort studies. Acta Psychiatr Scand. 2009;119(4):252–65. https://doi.org/10.1111/j.1600-0447.2008.01326.x.

Article  CAS  Google Scholar 

Canevelli M, Arisi I, Bacigalupo I, Arighi A, Galimberti D, Vanacore N, et al. Biomarkers and phenotypic expression in Alzheimer’s disease: exploring the contribution of frailty in the Alzheimer’s disease Neuroimaging Initiative. Geroscience. 2021;43(2):1039–51. https://doi.org/10.1007/s11357-020-00293-y.

Article  CAS  Google Scholar 

2020 Alzheimer’s disease facts and figures. Alzheimer’s Dement. 2020;16(3):391–460. https://doi.org/10.1002/alz.12068.

Kojima G, Liljas A, Iliffe S, Walters K. Prevalence of frailty in mild to moderate Alzheimer’s disease: a systematic review and meta-analysis. Curr Alzheimer Res. 2017;14(12):1256–63. https://doi.org/10.2174/1567205014666170417104236.

Article  CAS  Google Scholar 

Wallace LMK, Theou O, Godin J, Andrew MK, Bennett DA, Rockwood K. Investigation of frailty as a moderator of the relationship between neuropathology and dementia in Alzheimer’s disease: a cross-sectional analysis of data from the Rush Memory and Aging Project. Lancet Neurol. 2019;18(2):177–84. https://doi.org/10.1016/S1474-4422(18)30371-5.

Article  Google Scholar 

Ward DD, Ranson JM, Wallace LMK, Llewellyn DJ, Rockwood K. Frailty, lifestyle, genetics and dementia risk. J Neurol Neurosurg Psychiatry. 2022;93(4):343–50. https://doi.org/10.1136/jnnp-2021-327396.

Article  Google Scholar 

Canevelli M, Bruno G, Valletta M, Cesari M. Editorial: Could there Be Frailty in the discrepancy between lesions and symptoms of Alzheimer’s disease? J Frailty Aging. 2022;11(3):248–9. https://doi.org/10.14283/jfa.2022.43.

Article  CAS  Google Scholar 

Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–62. https://doi.org/10.1016/S0140-6736(12)62167-9.

Article  Google Scholar 

Hewitt J, Carter B, Vilches-Moraga A, Quinn TJ, Braude P, Verduri A, et al. The effect of frailty on survival in patients with COVID-19 (COPE): a multicentre, European, observational cohort study. Lancet Public Health. 2020;5(8):e444–51. https://doi.org/10.1016/S2468-2667(20)30146-8.

Article  Google Scholar 

Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci. 2004;59(3):M255–63. https://doi.org/10.1093/gerona/59.3.M255.

Article  Google Scholar 

Langlois F, Vu TTM, Kergoat M-J, Chassé K, Dupuis G, Bherer L. The multiple dimensions of frailty: physical capacity, cognition, and quality of life. Int Psychogeriatr. 2012;24(9):1429–36. https://doi.org/10.1017/S1041610212000634.

Article  Google Scholar 

Montero-Odasso MM, Barnes B, Speechley M, Muir Hunter SW, Doherty TJ, Duque G, et al. Disentangling cognitive-frailty: results from the gait and brain study. J Gerontol A Biol Sci Med Sci. 2016;71(11):1476–82. https://doi.org/10.1093/gerona/glw044.

Article  Google Scholar 

Dent E, Morley JE, Cruz-Jentoft AJ, Woodhouse L, Rodríguez-Mañas L, Fried LP, et al. Physical frailty: ICFSR international clinical practice guidelines for identification and management. J Nutr Health Aging. 2019;23(9):771–87. https://doi.org/10.1007/s12603-019-1273-z.

Article  CAS  Google Scholar 

Gobbens RJJ, van Assen MALM, Luijkx KG, Wijnen-Sponselee MT, Schols JMGA. Determinants of frailty. J Am Med Dir Assoc. 2010;11(5):356–64. https://doi.org/10.1016/j.jamda.2009.11.008.

Article  Google Scholar 

Howlett SE, Rutenberg AD, Rockwood K. The degree of frailty as a translational measure of health in aging. Nature Aging. 2021;1(8):651–65. https://doi.org/10.1038/s43587-021-00099-3.

Article  Google Scholar 

Bray NW, Jones GJ, Rush KL, Jones CA, Jakobi JM. Practical implications for strength and conditioning of older pre-frail females. J Frailty Aging. 2020;9(2):118–21. https://doi.org/10.14283/jfa.2020.15.

Article  CAS  Google Scholar 

Bray NW, Jones GJ, Rush KL, Jones CA, Jakobi JM. Multi-component exercise with high-intensity, free-weight, functional resistance training in pre-frail females: a quasi-experimental, pilot study. J Frailty Aging. 2020;9(2):111–7. https://doi.org/10.14283/jfa.2020.13.

Article  CAS  Google Scholar 

Rogers NT, Steptoe A, Cadar D. Frailty is an independent predictor of incident dementia: Evidence from the English Longitudinal Study of Ageing. Sci Rep. 2017;7(1):15746. https://doi.org/10.1038/s41598-017-16104-y.

Article  CAS  Google Scholar 

Wallace L, Hunter S, Theou O, Fleming J, Rockwood K, Brayne C. Frailty and neuropathology in relation to dementia status: the Cambridge City over-75s cohort study. Int Psychogeriatr. 2021:1–9. https://doi.org/10.1017/S1041610220003932.

López-Sanz D, Suárez-Méndez I, Bernabé R, Pasquín N, Rodríguez-Mañas L, Maestú F, et al. Scoping review of neuroimaging studies investigating frailty and frailty components. Front Med. 2018;5:284. https://doi.org/10.3389/fmed.2018.00284.

Article  Google Scholar 

Tian Q, Williams OA, Landman BA, Resnick SM, Ferrucci L. Microstructural neuroimaging of frailty in cognitively normal older adults. Front Med. 2020;7:546344. https://doi.org/10.3389/fmed.2020.546344.

Article  Google Scholar 

Damoiseaux JS, Beckmann CF, Arigita EJS, Barkhof F, Scheltens P, Stam CJ, et al. Reduced resting-state brain activity in the “default network” in normal aging. Cereb Cortex. 2008;18(8):1856–64. https://doi.org/10.1093/cercor/bhm207.

Article  CAS  Google Scholar 

Bressler SL, Menon V. Large-scale brain networks in cognition: emerging methods and principles. Trends Cogn Sci. 2010;14(6):277–90. https://doi.org/10.1016/j.tics.2010.04.004.

Article  Google Scholar 

Sheline YI, Raichle ME. Resting state functional connectivity in preclinical Alzheimer’s disease. Biol Psychiat. 2013;74(5):340–7. https://doi.org/10.1016/j.biopsych.2012.11.028.

Article  Google Scholar 

Suárez-Méndez I, Doval S, Walter S, Pasquín N, Bernabé R, Gallo EC, et al. Functional connectivity disruption in frail older adults without global cognitive deficits. Front Med. 2020;7:322. https://doi.org/10.3389/fmed.2020.00322.

Article  Google Scholar 

Lammers F, Zacharias N, Borchers F, Mörgeli R, Spies CDCD, Winterer G. Functional connectivity of the supplementary motor network is associated with Fried’s modified frailty score in the elderly. J Gerontol A Biol Sci Med Sci. 2020;75(12):2239–48. https://doi.org/10.1093/GERONA/GLZ297.

Article  Google Scholar 

Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–57. https://doi.org/10.1093/gerona/56.3.M146.

Article  CAS  Google Scholar 

Mitnitski AB, Mogilner AJ, Rockwood K. Accumulation of deficits as a proxy measure of aging. Sci World J. 2001;1:323–36. https://doi.org/10.1100/tsw.2001.58.

Article  CAS  Google Scholar 

Ritchie SJ, Cox SR, Shen X, Lombardo MV, Reus LM, Alloza C, et al. Sex differences in the adult human brain: evidence from 5216 UK Biobank Participants. Cereb Cortex. 2018;28(8):2959–75. https://doi.org/10.1093/cercor/bhy109.

Article  Google Scholar 

Alisch JSR, Khattar N, Kim RW, Cortina LE, Ac R, Qian W, et al. Sex and age-related differences in cerebral blood flow investigated using pseudo-continuous arterial spin labeling magnetic resonance imaging. Aging. 2021;13(4):4911-4925. https://doi.org/10.18632/AGING.202673.

Petersen RC, Roberts RO, Knopman DS, Geda YE, Cha RH, Pankratz VS, et al. Prevalence of mild cognitive impairment is higher in men. The Mayo Clinic Study of Aging. Neurology. 2010;75(10):889–97. https://doi.org/10.1212/WNL.0b013e3181f11d85.

Article  CAS  Google Scholar 

Collard RM, Boter H, Schoevers RA, Oude Voshaar RC. Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc. 2012;60(8):1487–92. https://doi.org/10.1111/j.1532-5415.2012.04054.x.

Article  Google Scholar 

Montero-Odasso M, Almeida QJ, Burhan AM, Camicioli R, Doyon J, Fraser S, et al. SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment. BMC Geriatrics. 2018;18(1):93. https://doi.org/10.1186/s12877-018-0782-7.

Article  CAS  Google Scholar 

Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):270–9. https://doi.org/10.1016/j.jalz.2011.03.008.

Article  Google Scholar 

Warburton DER, Bredin SSD, Jamnik VK, Gledhill N. Validation of the PAR-Q+ and ePARmed-X+. Health Fit J Can. 2011;4(2):38–46. https://doi.org/10.14288/hfjc.v4i2.151.

Article  Google Scholar 

Rockwood K, Mitnitski A. Frailty in relation to the accumulation of deficits. J Gerontol - Ser A Biol Sci Med Sci. 2007;62(7):722–7. https://doi.org/10.1093/gerona/62.7.722.

Article  Google Scholar 

Widagdo IS, Pratt N, Russell M, Roughead EE. Construct validity of four frailty measures in an older Australian population: a Rasch analysis. J Frailty Aging. 2016;5(2):78–81. https://doi.org/10.14283/jfa.2016.83.

Article  CAS  Google Scholar 

Kimber D, Kehler D, Lytwyn J, Boreskie K, Jung P, Alexander B, et al. Pre-operative frailty status is associated with cardiac rehabilitation completion: a retrospective cohort study. J Clin Med. 2018;7(12):560. https://doi.org/10.3390/jcm7120560.

Article  Google Scholar 

Kehler DS, Giacomantonio N, Firth W, Blanchard CM, Rockwood K, Theou O. Association between cardiac rehabilitation and frailty. Can J Cardiol. 2020;36(4):482–9. https://doi.org/10.1016/j.cjca.2019.08.032.

Article  Google Scholar 

Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K. A standard procedure for creating a frailty index. BMC Geriatrics. 2008;8:24. https://doi.org/10.1186/1471-2318-8-24.

Article  Google Scholar 

Duchesne S, Chouinard I, Potvin O, Fonov VS, Khademi A, Bartha R, et al. The Canadian dementia imaging protocol: harmonizing national cohorts. J Magn Reson Imaging. 2019;49(2):456–65. https://doi.org/10.1002/jmri.26197.

Article  Google Scholar 

Gorgolewski KJ, Auer T, Calhoun VD, Craddock RC, Das S, Duff EP, et al. The brain imaging data structure, a format for organizing and describing outputs of neuroimaging experiments. Sci Data. 2016;3(1):160044. https://doi.org/10.1038/sdata.2016.44.

Article  Google Scholar 

Esteban O, Markiewicz CJ, Goncalves M, DuPre E, Kent JD, Salo T, et al. fMRIPrep: a robust preprocessing pipeline for functional MRI. Nat Methods. 2020. https://doi.org/10.5281/ZENODO.4055773.

Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TEJ, Johansen-Berg H, et al. Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage. 2004;23:S208–19. https://doi.org/10.1016/J.NEUROIMAGE.2004.07.051.

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