Should Antidepressants be Avoided in Pregnancy?

Ferrari AJ, Charlson FJ, Norman RE, Flaxman AD, Patten SB, Vos T, et al. The epidemiological modelling of major depressive disorder: application for the global burden of disease study 2010. PLoS ONE. 2013;8: e69637.

Article  CAS  Google Scholar 

Rich-Edwards JW, Kleinman K, Abrams A, Harlow BL, McLaughlin TJ, Joffe H, et al. Sociodemographic predictors of antenatal and postpartum depressive symptoms among women in a medical group practice. J Epidemiol Community Health. 2006;60:221.

Article  Google Scholar 

Burt VK, Stein K. Epidemiology of depression throughout the female life cycle. J Clin Psychiatry. 2002;63(Suppl. 7):9–15.

Google Scholar 

Wisner KL, Gelenberg AJ, Leonard H, Zarin D, Frank E. Pharmacologic treatment of depression during pregnancy. JAMA. 1999;282:1264–9.

Article  CAS  Google Scholar 

Woody CA, Ferrari AJ, Siskind DJ, Whiteford HA, Harris MG. A systematic review and meta-regression of the prevalence and incidence of perinatal depression. J Affect Disord. 2017;219:86–92.

Article  CAS  Google Scholar 

Andersson L, Sundström-Poromaa I, Bixo M, Wulff M, Bondestam K, Åström M. Point prevalence of psychiatric disorders during the second trimester of pregnancy: a population-based study. Am J Obstet Gynecol. 2003;189:148–54.

Article  Google Scholar 

Marcus SM, Flynn HA, Blow FC, Barry KL. Depressive symptoms among pregnant women screened in obstetrics settings. J Womens Health. 2003;12:373–80.

Article  Google Scholar 

Khalifeh H, Hunt IM, Appleby L, Howard LM. Suicide in perinatal and non-perinatal women in contact with psychiatric services: 15 year findings from a UK national inquiry. Lancet Psychiatry. 2016;3:233–42.

Article  Google Scholar 

Cohen LS, Altshuler LL, Harlow BL, Nonacs R, Newport DJ, Viguera AC, et al. Relapse of major depression during pregnancy in women who maintain or discontinue antidepressant treatment. JAMA. 2006;295:499–507.

Article  CAS  Google Scholar 

Flynn HA, Chermack ST. Prenatal alcohol use: the role of lifetime problems with alcohol, drugs, depression, and violence. J Stud Alcohol Drugs. 2008;69:500–9.

Article  Google Scholar 

Bonari L, Pinto N, Ahn E, Einarson A, Steiner M, Koren G. Perinatal risks of untreated depression during pregnancy. Can J Psychiatry. 2004;49:726–35.

Article  Google Scholar 

Hu R, Li Y, Zhang Z, Yan W. Antenatal depressive symptoms and the risk of preeclampsia or operative deliveries: a meta-analysis. PLoS ONE. 2015;10: e0119018.

Article  Google Scholar 

Mulder EJH, Robles de Medina PG, Huizink AC, Van den Bergh BRH, Buitelaar JK, Visser GHA. Prenatal maternal stress: effects on pregnancy and the (unborn) child. Early Hum Dev. 2002;70:3–14.

Article  CAS  Google Scholar 

Jarde A, Morais M, Kingston D, Giallo R, MacQueen GM, Giglia L, et al. Neonatal outcomes in women with untreated antenatal depression compared with women without depression: a systematic review and meta-analysis. JAMA Psychiat. 2016;73:826–37.

Article  Google Scholar 

Grigoriadis S, VonderPorten EH, Mamisashvili L, Tomlinson G, Dennis CL, Koren G, et al. The impact of maternal depression during pregnancy on perinatal outcomes: a systematic review and meta-analysis. J Clin Psychiatry. 2013;74:e321–41.

Article  Google Scholar 

Mongan D, Lynch J, Hanna D, Shannon C, Hamilton S, Potter C, et al. Prevalence of self-reported mental disorders in pregnancy and associations with adverse neonatal outcomes: a population-based cross-sectional study. BMC Pregnancy Childbirth. 2019;19:412.

Article  Google Scholar 

Gentile S. Untreated depression during pregnancy: short- and long-term effects in offspring: a systematic review. Neuroscience. 2017;342:154–66.

Article  CAS  Google Scholar 

Slomian J, Honvo G, Emonts P, Reginster J-Y, Bruyère O. Consequences of maternal postpartum depression: a systematic review of maternal and infant outcomes. Womens Health. 2019;15:1745506519844044.

CAS  Google Scholar 

Tuovinen S, Lahti-Pulkkinen M, Girchenko P, Lipsanen J, Lahti J, Heinonen K, et al. Maternal depressive symptoms during and after pregnancy and child developmental milestones. Depression Anxiety. 2018;35:732–41.

Article  Google Scholar 

Bind RH, Biaggi A, Bairead A, Du Preez A, Hazelgrove K, Waites F, et al. Mother-infant interaction in women with depression in pregnancy and in women with a history of depression: the Psychiatry Research and Motherhood - Depression (PRAM-D) study. BJPsych Open. 2021;7: e100.

Article  Google Scholar 

Jimenez-Solem E. Exposure to antidepressants during pregnancy: prevalences and outcomes. Dan Med J. 2014;61:B4916.

Google Scholar 

Chaudron LH. Complex challenges in treating depression during pregnancy. Am J Psychiatry. 2013;170:12–20.

Article  Google Scholar 

Adhikari K, Patten SB, Lee S, Metcalfe A. Adherence to and persistence with antidepressant medication during pregnancy: does it differ by the class of antidepressant medication prescribed? Can J Psychiatry. 2019;64:199–208.

Article  Google Scholar 

Bennett HA, Einarson A, Taddio A, Koren G, Einarson TR. Prevalence of depression during pregnancy: systematic review. Obstet Gynecol. 2004;103:698–709.

Article  Google Scholar 

Zoega H, Kieler H, Nørgaard M, Furu K, Valdimarsdottir U, Brandt L, et al. Use of SSRI and SNRI antidepressants during pregnancy: a population-based study from Denmark, Iceland. Norway and Sweden PLoS One. 2015;10: e0144474.

Article  Google Scholar 

National Institute for Health and Care Excellence (NICE). Depression: antenatal and postnatal: scenario: pregnant woman: on an antidepressant. 2022. Available from: https://cks.nice.org.uk/topics/depression-antenatal-postnatal/management/pregnant-on-an-antidepressant. [Accessed 29 Aug 2022].

Bérard A, Sheehy O, Zhao J-P, Chambers C, Roth M, Bozzo P, et al. Impact of antidepressant use, discontinuation, and dosage modification on maternal depression during pregnancy. Eur Neuropsychopharmacol. 2019;29:803–12.

Article  Google Scholar 

Kittel-Schneider S, Felice E, Buhagiar R, Lambregtse-Van Den Berg M, Wilson CA, Baljak VB, et al. Treatment of peripartum depression with antidepressants and other psychotropic medications: a synthesis of clinical practice guidelines in Europe. Int J Environ Res Public Health. 2022;19:1973.

Article  Google Scholar 

Molenaar NM, Kamperman AM, Boyce P, Bergink V. Guidelines on treatment of perinatal depression with antidepressants: an international review. Aust N Z J Psychiatry. 2018;52:320–7.

Article  Google Scholar 

Petersen I, Gilbert RE, Evans SJ, Man SL, Nazareth I. Pregnancy as a major determinant for discontinuation of antidepressants: an analysis of data from the Health Improvement Network. J Clin Psychiatry. 2011;72:979–85.

Article  Google Scholar 

Heikkinen T, Ekblad U, Laine K. Transplacental transfer of citalopram, fluoxetine and their primary demethylated metabolites in isolated perfused human placenta. BJOG. 2002;109:1003–8.

Article  CAS  Google Scholar 

Heikkinen T, Ekblad U, Laine K. Transplacental transfer of amitriptyline and nortriptyline in isolated perfused human placenta. Psychopharmacology. 2001;153:450–4.

Article  CAS  Google Scholar 

Fokina VM, West H, Oncken C, Clark SM, Ahmed MS, Hankins GDV, et al. Bupropion therapy during pregnancy: the drug and its major metabolites in umbilical cord plasma and amniotic fluid. Am J Obstet Gynecol. 2016;215(497):e1-7.

Google Scholar 

Loughhead AM, Fisher AD, Newport DJ, Ritchie JC, Owens MJ, DeVane CL, et al. Antidepressants in amniotic fluid: another route of fetal exposure. Am J Psychiatry. 2006;163:145–7.

Article  Google Scholar 

Schoretsanitis G, Westin AA, Stingl JC, Deligiannidis KM, Paulzen M, Spigset O. Antidepressant transfer into amniotic fluid, umbilical cord blood & breast milk: a systematic review & combined analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2021;107: 110228.

Article  CAS  Google Scholar 

Rampono J, Simmer K, Ilett KF, Hackett LP, Doherty DA, Elliot R, et al. Placental transfer of SSRI and SNRI antidepressants and effects on the neonate. Pharmacopsychiatry. 2009;42:95–100.

Article  CAS  Google Scholar 

Hendrick V, Stowe ZN, Altshuler LL, Hwang S, Lee E, Haynes D. Placental passage of antidepressant medications. Am J Psychiatry. 2003;160:993–6.

Article  Google Scholar 

Oberlander TF. Fetal serotonin signaling: setting pathways for early childhood development and behavior. J Adolesc Health. 2012;51:S9-16.

Article  Google Scholar 

Ko M-C, Lee LJ-H, Li Y, Lee L-J. Long-term consequences of neonatal fluoxetine exposure in adult rats. Dev Neurobiol. 2014;74:1038–51.

Article  CAS  Google Scholar 

Olivier JDA, Vallès A, van Heesch F, Afrasiab-Middelman A, Roelofs JJPM, Jonkers M, et al. Fluoxetine administration to pregnant rats increases anxiety-related behavior in the offspring. Psychopharmacology. 2011;217:419–32.

Article  CAS  Google Scholar 

Simpson KL, Weaver KJ, de Villers-Sidani E, Lu JY-F, Cai Z, Pang Y, et al. Perinatal antidepressant exposure alters cortical network function in rodents. Proc Natl Acad Sci U S A. 2011;108:18465–70.

Article  CAS  Google Scholar 

Lee L-J. Neonatal fluoxetine exposure affects the neuronal structure in the somatosensory cortex and somatosensory-related behaviors in adolescent rats. Neurotox Res. 2009;15:212–23.

Article  CAS  Google Scholar 

Creeley CE, Denton LK. Use of prescribed psychotropics during pregnancy: a systematic review of pregnancy, neonatal, and childhood outcomes. Brain Sci. 2019;9:235.

Article  CAS  Google Scholar 

Galbally M, Lewis AJ, Gentile S. The biology of fetal exposure to serotonin reuptake inhibitors: implications for neurodevelopment. In: Migne IJ, Post JW, editors. Antidepressants: pharmacology, health effects and controversy. New York (NY): Nova; 2012. p. 1–26.

Google Scholar 

Sadler TW. Selective serotonin reuptake inhibitors (SSRIs) and heart defects: potential mechanisms for the observed associations. Reprod Toxicol. 2011;32:484–9.

Article  CAS  Google Scholar 

Vitalis T, Parnavelas JG. The role of serotonin in early cortical development. Dev Neurosci. 2003;25:245–56.

Article  CAS  Google Scholar 

Bérard A, Zhao J-P, Sheehy O. Antidepressant use during pregnancy and the risk of major congenital malformations in a cohort of depressed pregnant women: an updated analysis of the Quebec Pregnancy Cohort. BMJ Open. 2017;7: e013372.

Article  Google Scholar 

Reis M, Källén B. Delivery outcome after maternal use of antidepressant drugs in pregnancy: an update using Swedish data. Psychol Med. 2010;40:1723–33.

Article  CAS 

留言 (0)

沒有登入
gif