Assessment of plasma catecholamines in patients with dysmetabolic iron overload syndrome

J Appl Biomed 20:141-145, 2022 | DOI: 10.32725/jab.2022.016

Hany William Z. Hanna1 *, Heba N Baz1, Lika'a Fasih Y. Al-Kzayer2, Hemmat E El Haddad3, Fatma El-Mougy1 1Cairo University, Kasr Al Ainy, Faculty of Medicine, Department of Clinical and Chemical Pathology, Cairo, Egypt 2Shinshu University School of Medicine, Department of Pediatrics, Matsumoto, Nagano, Japan 3Cairo University, Kasr Al Ainy, Faculty of Medicine, Department of Internal Medicine, Cairo, Egypt

Background: Dysmetabolic iron overload syndrome (DIOS) is characterized by hyperferritinemia and normal transferrin saturation level with components of metabolic syndrome (MS). Among cases of MS, we determined those with DIOS and their characterizations, then we evaluated the association between plasma catecholamines status and hypertension in DIOS.

Methods: We compared 101 hypertensive patients with 50 healthy participants (control group). Iron (iron, transferrin, and ferritin), insulin, and plasma catecholamine (adrenaline, noradrenaline, and dopamine), profiles were measured for both groups. Homeostasis model assessment of insulin resistance index and transferrin saturation were also calculated.

Results: Out of 101 hypertensive patients, 64 were diagnosed with MS, and 6 of the latter met the DIOS diagnostic criteria. Significantly, DIOS patients were older and had lower body mass index (BMI) compared with hypertensive non-DIOS patients with p-values of (0.026), and (0.033), respectively. Adrenaline, noradrenaline, and dopamine levels did not differ significantly between DIOS and non-DIOS patients.

Conclusions: Of the MS patients, 9.3% were diagnosed with DIOS. Accordingly, complete iron profiling should be performed routinely in the cases of MS for early diagnosis of DIOS, to prevent future complications. Further studies are required to test the hypothesis linking older age and lower BMI with the pathogenesis of DIOS.

Keywords: BMI; Catecholamines, DIOS; Hyperferritinemia, Hypertension; Metabolic syndrome Conflicts of interest:

The authors have no conflict of interests to declare.

Hanna HWZ, Baz HN, Al-Kzayer LFY, El Haddad HE, El-Mougy F. Assessment of plasma catecholamines in patients with dysmetabolic iron overload syndrome. J Appl Biomed. 2022;20(4):141-145. doi:10.32725/jab.2022.016.

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