The non-lytic release of ATP occurs in lymphoid tissues at a steady state.
•Purinergic signaling is induced by regulated ATP release from naïve T cells in response to chemokines.
•Extracellular ATP has a homeostatic role in immune cell migration in lymph nodes.
AbstractAntigen stimulation induces adenosine triphosphate (ATP) release from naïve lymphocytes in lymphoid tissues. However, previous studies indicated that the non-lytic release of ATP also occurs in most tissues and cell types under physiological conditions. Here, we show that extracellular ATP (eATP) is indeed constitutively produced by naïve T cells in response to lymphoid chemokines in uninflamed lymph nodes and is involved in the regulation of immune cell migration. In this review, we briefly summarize the homeostatic role of extracellular ATP in immune cell migration in vivo.
KeywordsATP
Purinergic receptor
Lymphocyte
Chemokine
Cell migration
AbbreviationsATPadenosine triphosphate
HEVhigh endothelial venule
S1Psphingosine-1-phosphate
MALD-IMSmatrix-assisted laser desorption/ionization imaging mass spectrometry
CE-ESI-MScapillary electrophoresis-electrospray ionization mass spectrometry
© 2022 The Author(s). Published by Elsevier Ltd.
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