Brown-Borg HM. Longevity in mice: is stress resistance a common factor? Age (Dordr). 2006;28(2):145–62.

Article  CAS  Google Scholar 

Coschigano KT, Clemmons D, Bellush LL, Kopchick JJ. Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology. 2000;141(7):2608–13.

Article  CAS  Google Scholar 

Coschigano KT, et al. Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology. 2003;144(9):3799–810.

Article  CAS  Google Scholar 

Salmon AB, et al. Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress. Am J Physiol Endocrinol Metab. 2005;289(1):E23-29.

Article  CAS  Google Scholar 

Hauck SJ, Aaron JM, Wright C, Kopchick JJ, Bartke A. Antioxidant enzymes, free-radical damage, and response to paraquat in liver and kidney of long-living growth hormone receptor/binding protein gene-disrupted mice. Horm Metab Res. 2002;34(9):481–6.

Article  CAS  Google Scholar 

Fang Y, et al. Lifespan of long-lived growth hormone receptor knockout mice was not normalized by housing at 30 degrees C since weaning. Aging Cell. 2020;19(5): e13123.

Article  CAS  Google Scholar 

Klein Hazebroek M, Keipert S. Adapting to the cold: a role for endogenous fibroblast growth factor 21 in thermoregulation? Front Endocrinol (Lausanne). 2020;11:389.

Article  Google Scholar 

Meyer CW, Ootsuka Y, Romanovsky AA. Body temperature measurements for metabolic phenotyping in mice. Front Physiol. 2017;8:520.

Article  Google Scholar 

Fang Y, et al. Effects of rapamycin on growth hormone receptor knockout mice. Proc Natl Acad Sci USA. 2018;115(7):E1495–503.

Article  CAS  Google Scholar 

Masternak MM, et al. Metabolic effects of intra-abdominal fat in GHRKO mice. Aging Cell. 2012;11(1):73–81.

Article  CAS  Google Scholar 

Lee P, et al. Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis. J Clin Endocrinol Metab. 2013;98(1):E98-102.

Article  CAS  Google Scholar 

Lee P, et al. Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. Cell Metab. 2014;19(2):302–9.

Article  CAS  Google Scholar 

Hanssen MJ, et al. Serum FGF21 levels are associated with brown adipose tissue activity in humans. Sci Rep. 2015;5:10275.

Article  CAS  Google Scholar 

Salminen A, Kaarniranta K, Kauppinen A. Regulation of longevity by FGF21: interaction between energy metabolism and stress responses. Ageing Res Rev. 2017;37:79–93.

Article  CAS  Google Scholar 

Potthoff MJ, et al. FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci USA. 2009;106(26):10853–8.

Article  CAS  Google Scholar 

Makela J, et al. Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1alpha in human dopaminergic neurons via Sirtuin-1. Springerplus. 2014;3:2.

Article  Google Scholar 

Ji LL, Kang C. Role of PGC-1alpha in sarcopenia: etiology and potential intervention - a mini-review. Gerontology. 2015;61(2):139–48.

Article  CAS  Google Scholar 

Liang H, Ward WF. PGC-1alpha: a key regulator of energy metabolism. Adv Physiol Educ. 2006;30(4):145–51.

Article  Google Scholar 

Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev. 2004;84(1):277–359.

Article  CAS  Google Scholar 

Kalinovich AV, de Jong JM, Cannon B, Nedergaard J. UCP1 in adipose tissues: two steps to full browning. Biochimie. 2017;134:127–37.

Article  CAS  Google Scholar 

Zhang Y, et al. The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. Elife. 2012;1: e00065.

Article  Google Scholar 

Schlein C, et al. FGF21 lowers plasma triglycerides by accelerating lipoprotein catabolism in white and brown adipose tissues. Cell Metab. 2016;23(3):441–53.

Article  CAS  Google Scholar 

Steinbaugh MJ, Sun LY, Bartke A, Miller RA. Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan. Am J Physiol Endocrinol Metab. 2012;303(4):E488-495.

Article  CAS  Google Scholar 

Jarrar YB, Lee SJ. Molecular functionality of cytochrome P450 4 (CYP4) genetic polymorphisms and their clinical implications. Int J Mol Sci. 2019;20(17):4274. https://doi.org/10.3390/ijms20174274.

Hsu MH, Savas U, Griffin KJ, Johnson EF. Human cytochrome p450 family 4 enzymes: function, genetic variation and regulation. Drug Metab Rev. 2007;39(2–3):515–38.

Article  CAS  Google Scholar 

Hardwick JP. Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases. Biochem Pharmacol. 2008;75(12):2263–75.

Article  CAS  Google Scholar 

Huang S, Howington MB, Dobry CJ, Evans CR, Leiser SF. Flavin-containing monooxygenases are conserved regulators of stress resistance and metabolism. Front Cell Dev Biol. 2021;9: 630188.

Article  Google Scholar 

Conti B, et al. Transgenic mice with a reduced core body temperature have an increased life span. Science. 2006;314(5800):825–8.

Article  CAS  Google Scholar 

Sanchez-Alavez M, Alboni S, Conti B. Sex- and age-specific differences in core body temperature of C57Bl/6 mice. Age (Dordr). 2011;33(1):89–99.

Article  CAS  Google Scholar 

Gagliano-Juca T, et al. Effects of testosterone administration (and its 5-alpha-reduction) on parenchymal organ volumes in healthy young men: findings from a dose-response trial. Andrology. 2017;5(5):889–97.

Article  CAS  Google Scholar 

Nucci RAB, et al. Effects of testosterone administration on liver structure and function in aging rats. Aging Male. 2017;20(2):134–7.

Article  CAS  Google Scholar 

Bartke A, Steele RE, Musto N, Caldwell BV. Fluctuations in plasma testosterone levels in adult male rats and mice. Endocrinology. 1973;92(4):1223–8.

Article  CAS  Google Scholar 

Al-Regaiey KA, Masternak MM, Bonkowski M, Sun L, Bartke A. Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction. Endocrinology. 2005;146(2):851–60.

Article  CAS  Google Scholar 

Zhou Y, et al. A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). Proc Natl Acad Sci USA. 1997;94(24):13215–20.

Article  CAS  Google Scholar 

Basu R, Qian Y, Kopchick JJ. Mechanisms in endocrinology: lessons from growth hormone receptor gene-disrupted mice: are there benefits of endocrine defects? Eur J Endocrinol. 2018;178(5):R155–81.

Article  CAS  Google Scholar 

Allard C, et al. Activation of hepatic estrogen receptor-alpha increases energy expenditure by stimulating the production of fibroblast growth factor 21 in female mice. Mol Metab. 2019;22:62–70.

Article  CAS  Google Scholar 

Hannibal KE, Bishop MD. Chronic stress, cortisol dysfunction, and pain: a psychoneuroendocrine rationale for stress management in pain rehabilitation. Phys Ther. 2014;94(12):1816–25.

Article  Google Scholar 

Schooling CM, Leung GM. Testosterone and cardiovascular risk. Lancet Diabetes Endocrinol. 2015;3(9):682.

Article  Google Scholar 

Mariotti A. The effects of chronic stress on health: new insights into the molecular mechanisms of brain-body communication. Future Sci OA. 2015;1(3):FSO23.

Article  Google Scholar 

Junnila RK, et al. Disruption of the GH receptor gene in adult mice increases maximal lifespan in females. Endocrinology. 2016;157(12):4502–13.

Article  CAS  Google Scholar 

List EO, et al. Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/- mice. Aging (Albany NY). 2015;7(7):500–12.

Article  CAS  Google Scholar 

List EO, et al. Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles. Endocrinology. 2014;155(5):1793–805.

Article  Google Scholar 

Nagarajan A, Srivastava H, Jablonsky J, Sun LY. Tissue-specific GHR knockout mice: an updated review. Front Endocrinol (Lausanne). 2020;11: 579909.

Article  Google Scholar 

Young JA, et al. Characterization of an intestine-specific GH receptor knockout (IntGHRKO) mouse. Growth Horm IGF Res. 2019;46–47:5–15.

Article  Google Scholar