Does Voluntary Medical Male Circumcision Reduce HIV Risk in Men Who Have Sex with Men?

UNAIDS. UNAIDS Data 2019. https://www.unaids.org/sites/default/files/media_asset/2019-UNAIDS-data_en.pdf. Accessed 20th March 2022.

Schaefer R, Schmidt H-MA, Ravasi G, et al. Adoption of guidelines on and use of oral pre-exposure prophylaxis: a global summary and forecasting study. Lancet HIV. 2021;8(8):e502–10.

Article  Google Scholar 

Abara WE, Oraka E, Jeffries Iv WL, Chavez P, Nasrullah M, DiNenno E. Prevalence and correlates of condom use among sexually active men who have sex with men in the United States: findings from the National Survey of Family Growth, 2002, 2006–10 and 2011–13. Sex Health. 2017;14(4):363–71.

Article  Google Scholar 

Valencia R, Wang LY, Dunville R, Sharma A, Sanchez T, Rosenberg E. Sexual risk behaviors in adolescent sexual minority males: a systematic review and meta-analysis. J Prim Prev. 2018;39(6):619–45.

Article  Google Scholar 

Auvert B, Taljaard D, Lagarde E, Sobngwi-Tambekou J, Sitta R, Puren A. Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial. PLoS Med. 2005;2(11):e298.

Article  Google Scholar 

Bailey RC, Moses S, Parker CB, et al. Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial. Lancet. 2007;369(9562):643–56.

Article  Google Scholar 

Gray RH, Kigozi G, Serwadda D, et al. Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial. Lancet. 2007;369(9562):657–66.

Article  Google Scholar 

Weiss HA, Quigley MA, Hayes RJ. Male circumcision and risk of HIV infection in sub-Saharan Africa: a systematic review and meta-analysis. AIDS. 2000;14(15):2361–70.

Article  CAS  Google Scholar 

Mehta SD, Moses S, Parker CB, Agot K, Maclean I, Bailey RC. Circumcision status and incident herpes simplex virus type 2 infection, genital ulcer disease, and HIV infection. AIDS. 2012;26(9):1141–9.

Article  Google Scholar 

Wiysonge CS, Kongnyuy EJ, Shey M, et al. Male circumcision for prevention of homosexual acquisition of HIV in men. Cochrane Database Syst Rev. 2011;(6):CD007496.

Beyrer C. Global prevention of HIV infection for neglected populations: men who have sex with men. Clin Infect Dis. 2010;50(Suppl 3):S108-113.

Article  Google Scholar 

Fankem SL, Wiysonge CS, Hankins CA. Male circumcision and the risk of HIV infection in men who have sex with men. Int J Epidemiol. 2008;37(2):353–5.

Article  Google Scholar 

Doerner R, McKeown E, Nelson S, Anderson J, Low N, Elford J. Circumcision and HIV infection among men who have sex with men in Britain: the insertive sexual role. Arch Sex Behav. 2013.

Gust DA, Wiegand RE, Kretsinger K, et al. Circumcision status and HIV infection among MSM: reanalysis of a phase III HIV vaccine clinical trial. AIDS. 2010;24(8):1135–43.

Article  CAS  Google Scholar 

Jameson DR, Celum CL, Manhart L, Menza TW, Golden MR. The association between lack of circumcision and HIV, HSV-2, and other sexually transmitted infections among men who have sex with men. Sex Transm Dis. 2010;37(3):147–52.

Article  Google Scholar 

Jozkowski K, Rosenberger JG, Schick V, Herbenick D, Novak DS, Reece M. Relations between circumcision status, sexually transmitted infection history, and HIV serostatus among a national sample of men who have sex with men in the United States. AIDS Patient Care STDS. 2010;24(8):465–70.

Article  Google Scholar 

Londish GJ, Templeton DJ, Regan DG, Kaldor JM, Murray JM. Minimal impact of circumcision on HIV acquisition in men who have sex with men. Sex Health. 2010;7(4):463–70.

Article  Google Scholar 

Sanchez J, Sal YRVG, Hughes JP, et al. Male circumcision and risk of HIV acquisition among MSM. AIDS. 2011;25(4):519–23.

Article  Google Scholar 

Schneider JA, Michaels S, Gandham SR, et al. A protective effect of circumcision among receptive male sex partners of Indian men who have sex with men. AIDS Behav. 2012;16(2):350–9.

Article  Google Scholar 

Zhou C, Raymond HF, Ding X, et al. Anal sex role, circumcision status, and HIV infection among men who have sex with men in Chongqing, China. Arch Sex Behav. 2012.

Millett GA, Flores SA, Marks G, Reed JB, Herbst JH. Circumcision status and risk of HIV and sexually transmitted infections among men who have sex with men: a meta-analysis. JAMA. 2008;300(14):1674–84.

Article  CAS  Google Scholar 

•• Sharma SC, Raison N, Khan S, Shabbir M, Dasgupta P, Ahmed K. Male circumcision for the prevention of human immunodeficiency virus (HIV) acquisition: a meta-analysis. 2018;121(4):515–526. This meta-analysis of 18 studies showed that circumcision was associated with a 20% reduction in HIV risk among homosexual men.

•• Zhang C, Qian H-Z, Liu Y, Vermund SH. Voluntary medical male circumcision and HIV infection among men who have sex with men: Implications from a systematic review. SAGE Open Med. 2019;7:2050312119869110. This meta-analysis of 33 studies showed that circumcision was associated with a 3% reduction in HIV risk among MSM.

•• Yuan T, Fitzpatrick T, Ko N-Y, et al. Circumcision to prevent HIV and other sexually transmitted infections in men who have sex with men: a systematic review and meta-analysis of global data. Lancet Glob Health. 2019;7(4):e436-e447. This meta-analysis of 43 studies showed that circumcision was associated with a 23% reduction in HIV risk among MSM.

Twahirwa Rwema JO, Lyons CE, Herbst S, et al. HIV infection and engagement in HIV care cascade among men who have sex with men and transgender women in Kigali, Rwanda: a cross-sectional study. J Int AIDS Soc. 2020;23(Suppl 6):e25604.

Google Scholar 

DiPietro NA. Methods in epidemiology: observational study designs. Pharmacotherapy. 2010;30(10):973–84.

Article  Google Scholar 

Templeton DJ, Jin F, Prestage GP, et al. Circumcision and risk of sexually transmissible infections in a community-based cohort of HIV-negative homosexual men in Sydney. Australia J Infect Dis. 2009;200(12):1813–9.

Article  Google Scholar 

Hu Y, Qian HZ, Sun J, et al. Anal human papillomavirus infection among HIV-infected and uninfected men who have sex with men in Beijing, China. J Acquir Immune Defic Syndr. 2013.

Brown JE, Micheni KD, Grant EM, Mwenda JM, Muthiri FM, Grant AR. Varieties of male circumcision: a study from Kenya. Sex Transm Dis. 2001;28(10):608–12.

Article  CAS  Google Scholar 

Xu F, Markowitz LE, Sternberg MR, Aral SO. Prevalence of circumcision and herpes simplex virus type 2 infection in men in the United States: the National Health and Nutrition Examination Survey (NHANES), 1999–2004. Sex Transm Dis. 2007;34(7):479–84.

Article  Google Scholar 

Maughan-Brown B, Venkataramani AS. Learning that circumcision is protective against HIV: risk compensation among men and women in Cape Town, South Africa. PLoS One. 2012;7(7):e40753.

Article  CAS  Google Scholar 

Ayiga N, Letamo G. Impact of male circumcision on HIV risk compensation through the impediment of condom use in Botswana. Afr Health Sci. 2011;11(4):550–9.

CAS  Google Scholar 

Eaton LA, Cain DN, Agrawal A, Jooste S, Udemans N, Kalichman SC. The influence of male circumcision for HIV prevention on sexual behaviour among traditionally circumcised men in Cape Town. South Africa Int J STD AIDS. 2011;22(11):674–9.

Article  CAS  Google Scholar 

Peltzer K, Simbayi L, Banyini M, Kekana Q. HIV risk reduction intervention among traditionally circumcised young men in South Africa: a cluster randomized control trial. J Assoc Nurses AIDS Care. 2011;22(5):397–406.

Article  Google Scholar 

Riess TH, Achieng MM, Otieno S, Ndinya-Achola JO, Bailey RC. “When I was circumcised I was taught certain things”: risk compensation and protective sexual behavior among circumcised men in Kisumu, Kenya. PLoS One. 2010;5(8):e12366.

Article  Google Scholar 

Mattson CL, Campbell RT, Karabatsos G, et al. Scaling sexual behavior or “sexual risk propensity” among men at risk for HIV in Kisumu. Kenya AIDS Behav. 2010;14(1):162–72.

Article  CAS  Google Scholar 

•• Qian H-Z, Ruan Y, Liu Y, et al. Lower HIV risk among circumcised men who have sex with men in China: interaction with anal sex role in a cross-sectional study. J Acquir Immune Defic Syndr. 2016;71(4):444–451. This cross-sectional study demonstrated that VMMC and anal sexual role were independently and jointly associated with HIV risk among MSM.

Hunt AJ, Davies PM, Weatherburn P, Coxon AP, McManus TJ. Sexual partners, penetrative sexual partners and HIV risk. AIDS. 1991;5(6):723–8.

Article  CAS  Google Scholar 

Patel P, Borkowf CB, Brooks JT, Lasry A, Lansky A, Mermin J. Estimating per-act HIV transmission risk: a systematic review. AIDS. 2014;28(10):1509–19.

Article  Google Scholar 

Weiss HA, Halperin D, Bailey RC, Hayes RJ, Schmid G, Hankins CA. Male circumcision for HIV prevention: from evidence to action? AIDS. 2008;22(5):567–74.

Article  Google Scholar 

Gray RH, Wawer MJ, Polis CB, Kigozi G, Serwadda D. Male circumcision and prevention of HIV and sexually transmitted infections. Curr Infect Dis Rep. 2008;10(2):121–7.

Article  Google Scholar 

Macdonald A, Humphreys J, Jaffe HW. Prevention of HIV transmission in the UK: what is the role of male circumcision? Sex Transm Infect. 2008;84(3):158–60.

Article  Google Scholar 

•• Zhang C, Webb GF, Lou J, et al. Predicting the long-term impact of voluntary medical male circumcision on HIV incidence among men who have sex with men in Beijing, China. AIDS Care. 2020;32(3):343–353. This mathematical modelling study estimated that the number of new HIV cases would decrease by 16.3% during 2016 and 2026 if the annual coverage rate of VMMC increased to 15% among MSM.

Goodreau SM, Carnegie NB, Vittinghoff E, et al. Can male circumcision have an impact on the HIV epidemic in men who have sex with men? PLoS One. 2014;9(7):e102960.

Article  Google Scholar 

Buchbinder SP, Vittinghoff E, Heagerty PJ, et al. Sexual risk, nitrite inhalant use, and lack of circumcision associated with HIV seroconversion in men who have sex with men in the United States. J Acquir Immune Defic Syndr. 2005;39(1):82–9.

Article  Google Scholar 

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