Early Itch Response with Abrocitinib Is Associated with Later Efficacy Outcomes in Patients with Moderate-to-Severe Atopic Dermatitis: Subgroup Analysis of the Randomized Phase III JADE COMPARE Trial

Funding

This study was funded by Pfizer Inc.

Conflict of interest

SS is an investigator for Dermasence, Galderma, Kiniksa, Menlo Therapeutics, Novartis, Sanofi Genzyme, Trevi Therapeutics, and Vanda; a member of scientific advisory boards, consultant, and/or speaker for Pfizer Inc., AbbVie, Almirall, Beiersdorf, Bellus Health, Benevolent, Bionorica, Cara, Clexio, Eli Lilly, Escient, Galderma, Grünenthal, Kiniksa, LEO Pharma, Menlo Therapeutics, P.G. Unna Academy, Sanofi Genzyme, Trevi Therapeutics, and Vifor. SGK is an advisory board member/consultant for Pfizer Inc., AbbVie, Celldex Therapeutics, Galderma, Incyte Corporation, Kiniksa Pharmaceuticals, Novartis Pharmaceuticals Corporation, Regeneron Pharmaceuticals, and Sanofi Genzyme; and has served as an investigator for Pfizer Inc., Galderma, Kiniksa Pharmaceuticals, and Sanofi Genzyme. JIS has served as an investigator for Celgene, Eli Lilly, F. Hoffmann-La Roche, Menlo Therapeutics, Realm Therapeutics, Regeneron, and Sanofi Genzyme; as a consultant for Pfizer Inc., AbbVie, Anacor, AnaptysBio, Arena Pharmaceuticals, Dermavant, Dermira, Eli Lilly, Galderma, GlaxoSmithKline, Glenmark, Incyte, Kiniksa Pharmaceuticals, LEO Pharma, Menlo Therapeutics, Novartis, Realm Therapeutics, Regeneron Pharmaceuticals and Sanofi Genzyme; and as a speaker for Regeneron Pharmaceuticals and Sanofi Genzyme. ELS has received grants from Pfizer Inc., Eli Lilly, Kyowa Kirin, LEO Pharma, Merck, and Regeneron Pharmaceuticals and personal fees from Pfizer Inc., Bausch Health (Valeant), Dermira, Eli Lilly, Galderma, LEO Pharma, Menlo Therapeutics, Novartis, Regeneron, and Sanofi Genzyme. JPT is an advisor for Pfizer Inc., AbbVie, Almirall, Arena Pharmaceuticals, Aslan Pharmaceuticals, Eli Lilly, LEO Pharma, OM Pharma, Regeneron Pharmaceuticals, Sanofi Genzyme, and Union Therapeutics; a speaker for Pfizer Inc., AbbVie, Almirall, Eli Lilly, LEO Pharma, Regeneron Pharmaceuticals, and Sanofi Genzyme; and received research grants from Pfizer Inc., Regeneron Pharmaceuticals, and Sanofi Genzyme. GY has been a consultant and an advisor for Pfizer Inc., Bellus, Eli Lilly, Galderma, Kiniksa, LEO Pharma, Novartis, Sanofi Regeneron, and Trevi Therapeutics and a principal investigator for Pfizer Inc., Galderma, Kiniksa, LEO Pharma, and Sanofi Regeneron. HV, MDB, and CF are employees and shareholders of Pfizer Inc. FZ and RRC are former employees and shareholders of Pfizer Inc. MC is a former employee and shareholder of Pfizer Inc. and has been a speaker, member of scientific advisory boards, and/or a consultant for AbbVie, Eli Lilly, and Incyte.

Ethics approval

The trial was conducted in accordance with the principles of the Declaration of Helsinki and the International Council for Harmonization Good Clinical Practice guidelines. All local regulatory requirements were followed. This research was approved by the institutional review board or ethics committee at each trial site. This article does not contain any studies with animals performed by any of the authors.

Consent to participate

All patients provided written informed consent to participate in the study.

Consent to publish

Not applicable.

Availability of data

Upon request, and subject to review, Pfizer will provide the data that support the findings of this study. Subject to certain criteria, conditions, and exceptions, Pfizer may also provide access to the related individual de-identified participant data. See https://www.pfizer.com/science/clinical-trials/trial-data-and-results for more information.

Author contributions

SS, JIS, ELS, JPT, GY, MCC, RRC, HV, and CF contributed to the study conception and design. FZ performed the data acquisition and analysis. All authors contributed to the data interpretation, had full editorial control of the manuscript, and provided input and approval of all drafts, including the final submitted version.

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