1. IntroductionImproving patient safety is an essential component of quality of care and a central concern of the global healthcare setting. Medication errors are widely reported as causes of unintended harm to patients, thereby contributing to adverse events that diminish patient safety [1,2]. A medication error refers to any avoidable event that may result in inappropriate usage of therapeutic products or harmful effects on the patient. Although medication therapy is crucial in healthcare services, it can also be hazardous and life-threatening if misapplied [3].Approximately 7000 to 9000 Americans die due to a medication error annually [4]. Additionally, it was reported that at least one medication error occurs daily and such problems account for 100,000 hospitalizations annually [4]. Likewise, 7% of inpatients are exposed to medication errors (MEs) daily; the majority of such patients are in extended hospitalization care or referred to high dependency care unit or critical care [2,5]. Such intensive care is a high-complexity situation where medication administration often demands remarkable effort and interventions from healthcare providers [5]. Recent studies on the factors contributing to the occurrence of definite or potentially harmful events into human and organizational factors [5,6,7]. Human factors referred to healthcare workers’ personal and professional characteristics, whereas organizational factors are related to the organization of the drug management process. Other factors that may elicit medication error and malpractice include a lack of knowledge, lack of performance, slips, and lapses.Nurses play a crucial role in reinforcing patient safety [8]. Nursing errors in medication administration and medication malpractices are among the most underreported medical problems globally. Medication administration errors among nurses can have a significant impact on a patient’s health care costs, quality of life, and the delivery of nursing care. Hence, improving nurses’ knowledge of medication errors and their consequences is pertinent in order to address these issues [8]. Several studies have demonstrated associations between the prevalence of medication errors among nurses and medication administration knowledge [2,7,9]. Some studies reflect that about half of the therapeutic errors were linked to a lack of knowledge and performance. However, the exact relationship remains unclear given the contradicting outcomes reported in these studies.Medication error has also been associated with negligence in nursing care. Nursing care is a career that encompasses technical and cognitive skills, and an “innate mindset of caring [8]. Patient safety and safe practices are ensured when nursing care is provided by nurses with a positive attitude. Nurses with a positive attitude are constantly seeking extraordinary nursing practice. On the other hand, nurses that consider their position as “just a job” demonstrated a greater propensity to committing medication errors [7,8]. Certain behaviors such as a deficit in following guidelines, protocols, or procedures or ineffective controls, or discipline of dual controls were directly associated with a medication error [9,10]. Accumulated evidence from the literature depicts that the most frequent medication errors experienced by nurses involve missing or bypassing the administration, wrong medication, inappropriate doses, and errors in terms of patients, routes, rate, and timing of medication [8,11].Medication error has been highlighted as a common issue in health facilities in hospitals in the Kingdom of Saudi Arabia. A systematic review found that the incidence of medication errors was 44.4% in Saudi Arabia hospitals with prescribing and administration errors as the most frequently reported medication errors [12]. Meanwhile, Alshammari et al. [13] conducted a cross-sectional study among healthcare professionals and reported limited reporting of medication errors, and most participants lacked good knowledge of medication error stages and had no history of being trained on the issue. The only study that presented information regarding medication errors among nurses was performed by Harkan et al. [14]. The authors conducted a retrospective cross-sectional analysis in tertiary healthcare facilities in the Al-Qassim region of the KSA and found that medication errors by physicians and nurses accounted for 60.4% and 34.0% of the overall errors. The most recent study by Alyami et al. [15] reported a total of 4860 medication errors in a central hospital in Saudi Arabia whereby more than 50.0% of the medication errors were associated with ordering, prescribing, or transcribing medications.

The aforementioned studies reflect the limited information on the prevalence of medication errors in the Saudi Arabia context, especially among nurses. Presently, nurses’ understanding and attitudes toward medication errors remain underreported. Hence, this study aims to examine nurses’ knowledge and attitudes toward medication errors in Jeddah public hospitals in Saudi Arabia. The specific objectives were to (1) describe the socio-demographic characteristics, (2) determine the prevalence of medication errors, and (3) identify the factors associated with medication errors among the nurses in Jeddah public hospitals.

2. Materials and Methods 2.1. Study Area and Study DesignThis cross-sectional study was performed in four major public hospitals: King Fahad Hospital, King Abdulaziz Hospital, East Jeddah Hospital, and King Abdullah Medical Complex in Jeddah, Saudi Arabia. The study population comprised all the nurses registered in the Saudi commission for health specialties. The sampling frame was a list of updated working posts of all nurses from the human resources in the selected hospitals. A two-proportion sampling formula was used to calculate the sample size. The proportion of medication administration errors among the nurse in Saudi Arabia occurrence by main causes of medication administration error was used as two proportion variables to calculate the sample size. The total sample size was 408 subjects after considering a power of 80%, a 95% confidence level, and a 20% estimate of incomplete data. Cluster random sampling and proportional stratified sampling techniques were used to select the participants according to the density of the nurses in each hospital. The manuscript reporting was adhered to the STROBE guideline in the current study [16]. 2.2. Inclusion and Exclusion Criteria

The inclusion criteria were all the nurses registered in the Saudi commission for health specialties who completed at least one year of experience in their job in Jeddah hospitals regardless of their nationality, gender, age, educational level, or cultural background. Nurses on maternity leave, internship, and student nurses, nurses under one year of experience, and nurses who have not received the orientation program were excluded. A total of 408 nurses were selected according to the inclusion and exclusion criteria; 180 from King Fahad Hospital, 86 from King Abdulaziz hospital, and 71 each from East Jeddah hospital and King Abdullah Medical Complex.

2.3. Study Instrument and Measurement of the VariablesThe study instrument was adopted from the previous research conducted by Yung et al. [17] and presented in English. Specifically, the questionnaire comprised three broad sections that focused on nurses’ socio-demographic and cultural characteristics (i.e., age, gender, nationality, marital status, nurse’s role/profession, department/unit, education level, experience, monthly income, weekly work hours, first language, and their religion), organizational and hospital factors, and knowledge attitude and practice (KAP) on medication errors. The dependent variables were nurses’ KAP on medication errors, whereas socio-demographic and cultural characteristics and organizational/hospital factors were considered the independent variables.

The questions for nurses’ KAP were presented using multiple-choice and trichotomous questions: “Yes”, “No” and “I do not Know”. A total of 30 questions (Multiple-choice = 9, Trichotomous = 21) were presented in the instrument, and the responses were scored “1” for correct answers, and “0” for wrong answers. Meanwhile, the option “I do not know” was also scored as “0”. Questions with negative answers were coded inversely during analysis. Accordingly, the possible score that could be obtained by the respondents ranged from 0 to 30. For the dependent variables, nurses’ knowledge of medication error was categorized as good or poor based on the median or mean total score as depicted by the normality tests.

A total of 23 questions were utilized to assess nurses’ attitudes regarding medication errors. The questions were presented on a five-point Likert scale ranging from 5 = strongly agree to 1 = strongly disagree. Eight negatively termed questions were inversely recoded during data analysis. Thus, the possible score that could be obtained by the respondents ranged from 23 to 115. The attitude was further categorized as positive and negative based on the median or mean total score based on the data distribution. Lastly, three questions were designed to assess the type of medication error performed in the past 12 months and if the error was reported.

2.4. Ethical Approval

This study was approved by the Ethics Committee for Research Involving Human Subjects (JKEUPM) of Universiti Puta Malaysia (JKEUPM)] and by the Ministry of Health in Saudi Arabia. Written consent was obtained from all the hospitals and from all the participants, who all received written information about the study before data collection began. The participants had the opportunity to ask questions about the study before giving their consent.

2.5. Administration of the Questionnaire

Upon obtaining the necessary approval from each hospital, the principal officers in the selected hospitals were given consent forms to distribute to nurses via email. All the consent forms were signed by the nurses before participating in this study. Nurses were briefed about the purpose of the study and the confidentiality of all information provided via an online session before the main study. They were also informed that participation in this study is voluntary, and the results will be used only for research purposes. A set of self-administered questionnaires was then distributed to the respondents from January to March 2022 via Google Forms. All the respondents were required to complete the self-administered questionnaire by themselves by following the instructions.

2.6. Data Analysis

All the data analyses were performed using the software Statistical Package for Social Sciences (SPSS) version 26 for Microsoft Windows (Chicago, IL, USA). Normality tests and descriptive statistics were conducted for continuous variables to determine the data distribution. Thereafter, variables that were normally distributed were presented in means and standard deviations, whereas median and interquartile range was used to summarize the non-normally distributed data. Categorical variables were presented using frequencies and percentages. Associations between the variables were assessed using the Chi-square test and the significance level was set at a p-value < 0.05. The predictors of medication error were identified by performing binary logistic regression analyses. First, a univariate model was built to determine the crude odds ratio (COR) by testing each variable individually at a p-value of 0.10. Next, a multivariate model was built to identify the significant variables at a p-value of 0.05. Model fit was assessed based on the Akaike criterion and goodness of fit test.

4. DiscussionMedication errors remain a threat to patient safety in health facilities globally. Medication-related issues account for approximately up to 15% of hospital admissions in Saudi Arabia [18]. Previous studies have attributed these challenges to the persistent use of manual or handwritten prescripts and poor awareness of medication error reporting systems [19,20]. Despite the remarkable functions performed by nurses in patient handling and administration of medications, their understanding of medication errors is still underreported in the Saudi Arabia context. Elucidating their knowledge of medication errors will have a significant impact on patient safety [21,22]. Hence, this survey aimed to evaluate nurses’ knowledge and attitude toward medication errors and the associated factors.This study recorded a response rate of 100%, which is similar to the result from a recent investigation by Alshammari et al. [13] among healthcare professionals in the KSA, but higher relative to previous studies in the region [7,19] at 73.0% and 64.6%, respectively. The high response rate might be linked to the data collection method which is via online Google forms, as well as the instrument design, and the relevance of the topic to nurses in the selected hospitals. Most of the respondents (84.8%) were not older than 40 years old, with an overall mean (SD) of 34.04 (3.98) years. This finding reflects the age distribution of nurses in the country as reported in earlier studies [13] and those conducted elsewhere [23,24]. Furthermore, most of the nurses were females (68.9%), non-Saudi (51.2%), and had a bachelor’s degree (68.4%). The higher percentage of female nurses might be related to the gender distribution in Saudi Arabia, which is dominated by females as documented in other research as well [7,19,23]. Following the launching of the 2030 Saudi Arabia vision to improve healthcare services, healthcare professionals from various countries have been given the opportunity to work in the KSA [19], thereby contributing to the increased population of non-Saudi health workers including nurses. Meanwhile, the attainment of at least a bachelor’s degree in nursing is necessary to be qualified as a nurse and to work in Saudi Arabia.Identifying the extent of medication errors is pertinent in order to address the issue in healthcare systems. Hence, the prevalence of medication error among nurses was the first main objective of this study. The prevalence of medication error was 72.1%, and only 41.2% of the total were reported. This result highlights the high risk of medication error among nurses in Saudi Arabia, aligning with prior research in which nurses were responsible for 31.0% and 35.0% of medication errors recorded from retrospective and cross-sectional data in the country [14,15]. Moreover, the incidence of medication errors was 44.4% in Saudi Arabia hospitals with prescribing and administration errors as the most frequently reported medication errors [12]. Alsafi et al. [25] also disclosed that one-third of medication errors were associated with nurses. Consistent with the present study, 44.8% of nurses that experienced medication errors did not report the errors during their working experience [7].Medication errors can occur at any stage of medication use [24], especially during the prescription and administration stages [19]. Thus, these various stages of medication use were considered in the present study to evaluate nurses’ knowledge and attitude toward medication errors. Overall, slightly more than half of the nurses (55%) had good knowledge of medication errors, whereas only 50% demonstrated a positive attitude toward medication errors. In comparison to prior studies conducted in Saudi Arabia, this result is lower compared to 97% of participating nurses and physicians who had sufficient knowledge of medication errors [7]. The disparity might be related to the items used in assessing their knowledge and attitude, as well as the involvement of physicians and nurses in the latter study. Moreover, physicians are more educated and conversant about medication errors due to their training compared to nurses [13,14]. Studies conducted among nurses in other countries such as Bangladesh, India, and Nigeria reported contradicting findings as the participants demonstrated poor, moderate, and good knowledge of medication errors, respectively [6,9,26]. Knowledge of medication errors might be influenced by the courses designed in the nursing curriculum, training opportunities, and available facilities to improve nursing skills and expertise when discharging their responsibilities. In terms of attitude, results from the current study also contradict the reports by Salma et al. [7] in which 90% of nurses and physicians exhibited favorable attitudes toward medication errors. This outcome is not surprising given that knowledge and attitude toward medical-related issues are commonly correlated. In other words, nurses’ knowledge of medication errors often influences their attitude towards the issue [5]. These findings were further reflected in nurses’ responses to specific items used to assess knowledge and attitude towards medication errors in this study.Wrong dose (46.9%) was the most common type of medication error, followed by errors relating to patients (35.0%) while less than 10.0% were those associated with timing routes and documentation. These findings corroborate the outcomes reported by Alyami et al. [15] in which the most prevalent medication errors among nurses were related to either overdose or underdose and inappropriate dosage units. Wrong doses might be administered due to miscalculation of the correct dose, wrong decisions by the physician, and poor review by the latter during prescription [27]. Meanwhile, a lack of knowledge of how to calculate the correct dose may also contribute to high rates of administering wrong doses to patients [15]. Likewise, Lesar et al. [28] posited that medication errors are multifactorial but wrong doses are the most frequently reported causes. However, the numerous procedures involved in the prescription, transcription, dispensing, and administration reduce the risk of a medication reaching the 80% to 87% in this study believing that it is vital for the patient; otherwise, it elicits harm if it is either prescribed or transcribed wrongly [29].Most nurses reporting medication errors and patients and family members ought to be informed even if its adverse effect may occur or not in the patient. This reflects a positive attitude towards medication error reporting, which is similar to the finding by Alshammari et al. [13] in healthcare professionals in Saudi Arabia. The latter study found that 79.0% of participants opined that all medication errors be reported irrespective of whether they result in death or permanent hard, or even if no harm was experienced by the patient. On the other hand, some of the findings denoted poor knowledge and possibly a negative attitude towards medication error reporting among the nurses. For instance, between 50% to 60% agreed to not report a medication error rather than being blamed when they do otherwise, face the risk of being labeled a troublemaker, and the fear of their manager’s reaction, retribution, judicial issues, malpractice suits, and looking incompetent in front of their coworkers. To buttress these points, events such as the fear of punishment and having different cultural views about what constitutes an error were highlighted by most nurses as the reasons for underreporting medication errors. Studies conducted in Saudi Arabia have documented similar outcomes as legal implications, concerns about conflict with coworkers, and fear of impaired reputations were the factors that discouraged healthcare professionals from reporting medication errors [13]. Zarea et al. [2] also reported that the fear of legal consequences was the most significant factor associated with nurses’ unwillingness to report medication errors. Meanwhile, Teo et al. [24] identified the fear of being blamed as the reason for underreporting medication errors.In terms of mitigating these problems, more than one-third of the nurses agreed that educational interventions and training courses, conducting more research, and utilizing modern methods for drug information to improve scientific and practical skills will assist in reducing medication errors among nurses. Other suggestions included the use of bar-coding technology on medication labels, and dispensing technology. These findings align with the recommendations by the Saudi Arabian health ministry on how to mitigate medication errors among various healthcare professionals in the country [13,20].

Nurses from King Fahad and King Abdulaziz hospitals demonstrated lower odds of reporting medication errors compared to those from the King Abdullah Medical Complex. The likelihood of recording medication errors might differ between hospitals due to the availability and complexity of existing electronic reporting systems. The absence of an electronic reporting system might contribute to underreporting issues combined with the complexity of reporting protocols. The capacity of hospitals to implement these reporting systems might also differ due to the initial cost and provision of training for nurses to utilize the systems. As reported in this study, nurses with no history of attending a MER training course were more likely to experience medication errors.

In a prior study that documented a high prevalence of medication errors among healthcare professionals in Saudi Arabia, more than 50% of them did not receive any training on medication error reporting in the past two years [13]. Nurses in the present study might not have the opportunity to attend such training due to a lack of educational programs regarding medication safety and support from their hospitals. Given the busy schedules and workload allocated to nurses, they might not have the time to attend such an MER training course when organized. These events culminate in poor knowledge and negative attitudes toward medication errors as identified in this study. The odds of medication error were also less likely in nurses in the lower age group compared to those above 35 years old. Older nurses are more exposed to patient handling and management for their longer working experience in hospitals, thereby increasing their risk of experiencing medication errors [5]. Thus, educational and training programs on MER should be established and specifically designed for nurses in various hospitals in Saudi Arabia to improve their knowledge and attitude towards medication errors. Such strategies will assist in ensuring patient safety and quality of life.