Two-year follow-up of KTE-X19 in patients with relapsed or refractory adult B-cell acute lymphoblastic leukemia in ZUMA-3 and its contextualization with SCHOLAR-3, an external historical control study

Ethics approval and consent to participate

The study was conducted in accordance with the principles of the Declaration of Helsinki, the institutional review board or independent ethics committee at each study site approved the protocol, and all patients provided written informed consent.

Consent for publication

Not applicable.

Competing interests

BDS reports honoraria from Acrotech, Beigene, Gilead Sciences, Janssen, Pharmacyclics, and Spectrum; consulting/advisory role for Adaptive Biotechnologies, Amgen, Bristol-Myers Squibb (BMS)/Celgene, Kite, Novartis, Pfizer, and Precision Biosciences; research funding from Gilead Sciences, Incyte, Jazz Pharmaceuticals, and Kite; and travel support from Celgene, Janssen, Kite, Novartis, Pfizer, Seattle Genetics, and Stemline Therapeutics. AG reports consulting/advisory role for Amgen, Atara, Celgene, Kite, and Wugen Inc.; research funding from Amgen and Kite; and honoraria from Kite. OOO reports research funding from Kite and consulting/advisory role for Janssen, Pfizer, Novartis, Curio science, ADC therapeutics, TG therapeutics. ACL reports consulting/advisory role for Gilead, Kite, Roche, BMS/Celgene, Incyte, Takeda; research funding from Roche and Celgene; and travel support from Roche and Kite. NB reports honoraria and consulting or advisory role for Gilead. RDC reports employment with Seagen; stock or other ownership in Seagen; honoraria from Amgen, Kite, and Pfizer; consulting/advisory role for Amgen; research funding from Pfizer, Amgen, Kite, Merck, Pfizer, Servier, and Vanda. TL reports consultancy/advisory role for Amgen and Servier. MiRB reports honoraria from Agios, BMS, Celgene, Kite, Incyte, Novartis, and Sanofi; consulting/advisory role for Agios, Arcellx, Bluebird Bio, CRISPR Therapeutics, Iovance, Kite, Novartis, and WindMIL Therapeutics; speakers' bureau participation for Agios, BMS, Incyte, Kite, and Sanofi; research funding from Arcellx, Autolus, CRISPR Therapeutics, Immatics, Kite, Novartis, Triumvira, and Tmunity; and travel support from Agios, BMS, Incyte, Kite, and Novartis. MST reports consulting/advisory role for Amgen, Celgene, Kite, Regeneron, and Roche and research funding from Amgen, Kite, MacroGenics, Regeneron, and Roche. DT reports consulting/advisory role for BMS, EUSA, Partner, and Takeda, and research funding from BMS. KMO reports consulting/advisory role for BEAM Therapeutics. MLA reports consulting/advisory role for Kite and Syndax Pharmaceuticals, Inc.; research funding from Kite (Institutional PI). YL reports consulting/advisory role for Bluebird Bio, Celgene, Gamida Cell, Janssen, Novartis, Juno, Kite, Legend, Sorrento, and Vineti; research funding from Bluebird Bio, Celgene, Janssen, Kite, Merck, and Takeda. MaRB reports research funding from Abbvie, Ascentage, Kite, Kura, and Takeda. GJS reports stock or other ownership in Amgen, BMS, and Johnson & Johnson; honoraria from Agios, Amgen, AstraZeneca, Novartis, and Ono Pharma; consulting/advisory role for Agios, Celgene, and Jazz; speakers' bureau participation for Astellas, AbbVie, BMS, Celgene, Incyte, Karyopharm, Kite, and Stemline; research funding from AbbVie, Actinium, Actuate, Arog, Astellas, AVM Biopharma, Celgene, Cellectis, Cellerant, Constellation, CTI, Cyclacel, Forma, Daiichi-Sankyo, Deciphera, Delta-fly, FujiFilm, Gamida, Genentech/Roche, Geron, Gilead, Glycomimetics, Incyte, Janssen, Karyopharm, Kite, Mateon, Medimmune, Millennium, Novartis, Onconova, Pfizer, PreCOG, Regimmune, Samus, Sangamo, Sellas, Stemline, Takeda, Tolero, and Trovagene. JHP reports consulting/advisory role for AstraZeneca, Kite, and Novartis, and research funding from Amgen, Genentech, and Juno. MS reports consulting/advisory role for Amgen, Celgene/BMS, Gilead, Janssen, and Novartis; speakers' bureau participation for BMS/Celgene, Gilead, Janssen, and Novartis; research funding from Amgen, Gilead, Miltenyi Biotech, Morphosys, Roche, and Seattle Genetics; and travel support from Takeda. MA reports stock or other ownership with Cytodyn; consulting/advisory role for Celgene; speakers' bureau participation for Celgene, BMS, Abbvie, and Kite. MCM reports consulting/advisory role for BMS, and Janssen-Cilag; speakers bureau participation for Janssen-Cilag, and Medscape; WGW reports consulting/advisory role for Genzyme and Sanofi, and research funding from AbbVie, Acerta, Cyclacel, Genentech, Gilead, GlaxoSmithKline, Janssen, Juno, Karyopharm, Loxo Oncology, miRagen, Novartis, Oncternal, Pharmacyclics, Sunesis, and Xencor. DJD reports consulting or advisory role for Agios, Amgen, Autolos, Blueprint, Forty-Seven, Gilead, Incyte, Jazz, Novartis, Pfizer, Shire, and Takeda; research funding from AbbVie, Glycomimetics, Novartis and Blueprint Pharmaceuticals. PS reports honoraria from Karyopharm and MorphoSys; consulting/advisory role for CRISPR Therapeutics, Karyopharm, and MorphoSys; and research funding from Amgen, BMS, Gamida-Cell, Kite, Janssen, Macrogenics, and Seattle Genetics. DJ reports research funding from Jazz Pharmaceuticals and Pfizer. JD reports employment with Kite; stock or other ownership in Gilead Sciences; consulting/advisory role for GliaCure; and patents, royalties, or other intellectual property from: Patent US8598141 (Dec 03, 2013). SA reports employment and stock or other ownership with Kite. LZ reports employment with Kite and stock or other ownership in and travel support from AbbVie. PS reports employment with Kite; stock or other ownership in Gilead Sciences; and travel support from Kite and Gilead Sciences. IF reports employment with Kite; stock or other ownership of Gilead and Roche. BKM reports employment with and travel support from Kite, and stock or other ownership in GlaxoSmithKline, Kite, and Lava. RH reports honoraria from ADC therapeutics, BMS, Celgene, Gilead, Janssen, Kite, MSD, Novartis, and Roche, and consulting/advisory role for Kite/Gilead.

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