Relationship Between Abuse History and Gastrointestinal and Extraintestinal Symptom Severity in Irritable Bowel Syndrome

From the Department of Molecular and Clinical Medicine (Melchior, Wilpart, Midenfjord, Trindade, Törnblom, Tack, Simrén), Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; INSERM UMR 1073, Institute for Research and Innovation in Biomedicine (Melchior), Normandy University; Gastroenterology Department and INSERM CIC-CRB 1404 (Melchior), Rouen University Hospital, Rouen, France; Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism (Tack), KU Leuven, Leuven, Belgium; Center for Functional GI and Motility Disorders, University of North Carolina (Simrén), Chapel Hill, North Carolina; Laboratory for Brain-Gut Axis Studies (LaBGAS), Translational Research Center for Gastrointestinal Disorders (TARGID) (Oudenhove), Department of Chronic Diseases and Metabolism, KU Leuven; Liaison Psychiatry (Oudenhove), University Psychiatric Centre KU Leuven, Campus Gasthuisberg; Leuven Brain Institute, KU Leuven (Oudenhove), Leuven, Belgium; and Cognitive and Affective Neuroscience Lab, Department of Psychological and Brain Sciences (Oudenhove), Dartmouth College, Hanover, New Hampshire.

Address correspondence to Chloé Melchior, MD, PhD, Department of Molecular and Clinical Medicine Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden. E-mail: [email protected]

Received for publication January 3, 2022; revision received July 13, 2022.

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