Clinical Investigations – Research Article
Megna M.a· De Lucia M.a· Gallo L.a· Lauro W.a· Picone V.a· Fabbrocini G.a· Ocampo-Garza S.S.baDepartment of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy
bDermatology Department, University Hospital “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, Mexico
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Article / Publication DetailsFirst-Page Preview
Received: September 11, 2022
Accepted: November 04, 2022
Published online: December 08, 2022
Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 0
ISSN: 2296-9195 (Print)
eISSN: 2296-9160 (Online)
For additional information: https://www.karger.com/SAD
AbstractIntroduction: Psoriatic alopecia is considered a type of hair loss occurring in patients with psoriasis. Adalimumab is a fully humanized recombinant anti-TNF-alpha monoclonal antibody approved for treatment of psoriasis and psoriatic arthritis (PsA), rarely related to the occurrence of dermatological disorders. Case Presentation: We report the case of a 56-year-old female with PsA developing psoriatic alopecia and paradoxical psoriasis induced by adalimumab and successfully treated switching to certolizumab, evaluating response at both thrichoscopy and in vivo reflectance confocal microscopy. Discussion: Among anti-TNF-α agents, certolizumab is the least involved in the development of paradoxical reactions such as psoriatic alopecia and showed to be an effective and safe alternative therapeutic options to manage psoriasis and PsA minimizing the risk of paradoxical reactions.
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Received: September 11, 2022
Accepted: November 04, 2022
Published online: December 08, 2022
Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 0
ISSN: 2296-9195 (Print)
eISSN: 2296-9160 (Online)
For additional information: https://www.karger.com/SAD
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