Less is more: a critical role of synapse pruning in neural circuit wiring

One of the marvels of the brain is its ability to adapt to changes in the environment, especially during early development. This capacity resides largely in synapses, which are the basic building blocks of neural circuits. Rapid synaptogenesis occurs during early postnatal development and is followed by a progressive reduction in synapse number, in a process known as synapse elimination, or pruning, that continues into adolescence and adulthood and is thought to be critical to neural circuit refinement.

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