Libby, P. The changing landscape of atherosclerosis. Nature 592, 524–533 (2021).

Article  CAS  Google Scholar 

Musunuru, K. Moving toward genome-editing therapies for cardiovascular diseases. J. Clin. Invest. 132, e148555 (2022).

Article  Google Scholar 

Li, P., Ge, J. & Li, H. Lysine acetyltransferases and lysine deacetylases as targets for cardiovascular disease. Nat. Rev. Cardiol. 17, 96–115 (2020).

Article  CAS  Google Scholar 

Anene-Nzelu, C. G., Lee, M. C. J., Tan, W. L. W., Dashi, A. & Foo, R. S. Y. Genomic enhancers in cardiac development and disease. Nat. Rev. Cardiol. 19, 7–25 (2022).

Article  Google Scholar 

Santovito, D. & Weber, C. Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease. Nat. Rev. Cardiol. 19, 620–638 (2022).

Article  CAS  Google Scholar 

He, C. Grand challenge commentary: RNA epigenetics? Nat. Chem. Biol. 6, 863–865 (2010).

Article  CAS  Google Scholar 

Saletore, Y. et al. The birth of the epitranscriptome: deciphering the function of RNA modifications. Genome Biol. 13, 175 (2012).

Article  CAS  Google Scholar 

Wang, X. et al. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature 505, 117–120 (2014).

Article  Google Scholar 

Benne, R. et al. Major transcript of the frameshifted coxII gene from trypanosome mitochondria contains four nucleotides that are not encoded in the DNA. Cell 46, 819–826 (1986).

Article  CAS  Google Scholar 

Slobodin, B. et al. Transcription impacts the efficiency of mRNA translation via co-transcriptional N6-adenosine methylation. Cell 169, 326–337.e12 (2017).

Article  CAS  Google Scholar 

Hsiao, Y. E. et al. RNA editing in nascent RNA affects pre-mRNA splicing. Genome Res. 28, 812–823 (2018).

Article  CAS  Google Scholar 

Wei, J. et al. Differential m(6)A, m(6)Am, and m(1)A demethylation mediated by FTO in the cell nucleus and cytoplasm. Mol. Cell 71, 973–985.e5 (2018).

Article  CAS  Google Scholar 

Mauer, J. et al. Reversible methylation of m(6)Am in the 5′ cap controls mRNA stability. Nature 541, 371–375 (2017).

Article  CAS  Google Scholar 

Huang, H. et al. Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally. Nature 567, 414–419 (2019).

Article  CAS  Google Scholar 

Xu, W. et al. Dynamic control of chromatin-associated m(6)A methylation regulates nascent RNA synthesis. Mol. Cell 82, 1156–1168.e7 (2022).

Article  CAS  Google Scholar 

Ota, H. et al. ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing. Cell 153, 575–589 (2013).

Article  CAS  Google Scholar 

Desrosiers, R., Friderici, K. & Rottman, F. Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc. Natl Acad. Sci. USA 71, 3971–3975 (1974).

Article  CAS  Google Scholar 

Levanon, E. Y. et al. Systematic identification of abundant A-to-I editing sites in the human transcriptome. Nat. Biotechnol. 22, 1001–1005 (2004).

Article  CAS  Google Scholar 

Dominissini, D. et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 485, 201–206 (2012).

Article  CAS  Google Scholar 

Meyer, K. D. et al. Comprehensive analysis of mRNA methylation reveals enrichment in 3′ UTRs and near stop codons. Cell 149, 1635–1646 (2012).

Article  CAS  Google Scholar 

Higuchi, M. et al. Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2. Nature 406, 78–81 (2000).

Article  CAS  Google Scholar 

Wang, Q. et al. Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene. J. Biol. Chem. 279, 4952–4961 (2004).

Article  CAS  Google Scholar 

Hartner, J. C. et al. Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1. J. Biol. Chem. 279, 4894–4902 (2004).

Article  CAS  Google Scholar 

Liddicoat, B. J. et al. RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself. Science 349, 1115–1120 (2015).

Article  CAS  Google Scholar 

Geula, S. et al. Stem cells. m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation. Science 347, 1002–1006 (2015).

Article  CAS  Google Scholar 

Pecori, R., Di Giorgio, S., Lorenzo, J. P. & Papavasiliou, F. N. Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination. Nat. Rev. Genet. 23, 505–518 (2022).

Article  CAS  Google Scholar 

Moshitch-Moshkovitz, S., Dominissini, D. & Rechavi, G. The epitranscriptome toolbox. Cell 185, 764–776 (2022).

Article  CAS  Google Scholar 

Wiener, D. & Schwartz, S. The epitranscriptome beyond m(6)A. Nat. Rev. Genet. 22, 119–131 (2021).

Article  CAS  Google Scholar 

Zhang, C. et al. m(6)A modulates haematopoietic stem and progenitor cell specification. Nature 549, 273–276 (2017).

Article  CAS  Google Scholar 

Medvinsky, A. & Dzierzak, E. Definitive hematopoiesis is autonomously initiated by the AGM region. Cell 86, 897–906 (1996).

Article  CAS  Google Scholar 

Lv, J. et al. Endothelial-specific m(6)A modulates mouse hematopoietic stem and progenitor cell development via Notch signaling. Cell Res. 28, 249–252 (2018).

Article  Google Scholar 

Zhang, P. et al. G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition. Cell Res. 25, 1093–1107 (2015).

Article  CAS  Google Scholar 

Lizama, C. O. et al. Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition. Nat. Commun. 6, 7739 (2015).

Article  Google Scholar 

Gama-Norton, L. et al. Notch signal strength controls cell fate in the haemogenic endothelium. Nat. Commun. 6, 8510 (2015).

Article  CAS  Google Scholar 

Parial, R. et al. Role of epigenetic m(6)A RNA methylation in vascular development: mettl3 regulates vascular development through PHLPP2/mTOR-AKT signaling. FASEB J. 35, e21465 (2021).

Article  CAS  Google Scholar 

Liu, J. et al. m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat. Cell Biol. 20, 1074–1083 (2018).

Article  CAS  Google Scholar 

Yao, M. D. et al. Role of METTL3-dependent N(6)-methyladenosine mRNA modification in the promotion of angiogenesis. Mol. Ther. 28, 2191–2202 (2020).

Article  CAS  Google Scholar 

Hartner, J. C., Walkley, C. R., Lu, J. & Orkin, S. H. ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. Nat. Immunol. 10, 109–115 (2009).

Article  CAS  Google Scholar 

Guo, X. et al. ADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathway. Life Sci. Alliance 5, e202101191 (2022).

Article  CAS  Google Scholar 

Dorn, L. E. et al. The N(6)-methyladenosine mRNA methylase METTL3 controls cardiac homeostasis and hypertrophy. Circulation 139, 533–545 (2019).

Article  CAS  Google Scholar 

Moore, J. B. T. et al. The A-to-I RNA editing enzyme Adar1 is essential for normal embryonic cardiac growth and development. Circ. Res. 127, 550–552 (2020).

Article  CAS  Google Scholar 

McFadden, D. G. et al. The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development 132, 189–201 (2005).

Article  CAS  Google Scholar 

Stanley, E. G. et al. Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3′UTR-ires-Cre allele of the homeobox gene Nkx2-5. Int. J. Dev. Biol. 46, 431–439 (2002).

CAS  Google Scholar 

Garcia-Gonzalez, C. et al. ADAR1 prevents autoinflammatory processes in the heart mediated by IRF7. Circ. Res https://doi.org/10.1161/CIRCRESAHA.122.320839 (2022).

Article  Google Scholar 

Latinkic, B. V. et al. Transcriptional regulation of the cardiac-specific MLC2 gene during Xenopus embryonic development. Development 131, 669–679 (2004).

Article  CAS  Google Scholar 

Chen, J. et al. Global RNA editing identification and characterization during human pluripotent-to-cardiomyocyte differentiation. Mol. Ther. Nucleic Acids 26, 879–891 (2021).

Article  CAS  Google Scholar 

Stellos, K. et al. Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation. Nat. Med. 22, 1140–1150 (2016).

Article  CAS