Effects of Dapagliflozin on Hospitalizations in Patients With Chronic Kidney Disease

Affiliations:

Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands, Diabetes Unit, Department of Endocrinology and Metabolism, Hadassah Medical Center, Jerusalem, Israel, and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel (M.S.)

Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (N.J.)

Department of Medicine and Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California (G.M.C.)

Diabetes Unit, Department of Endocrinology and Metabolism, Hadassah Medical Center, and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel (O.M.)

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.J.V.M.)

The National Medical Science and Nutrition Institute Salvador Zubiran, Mexico City, Mexico (R.C.)

Steno Diabetes Center Copenhagen, Gentofte, Denmark, and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark (P.R.)

Late-Stage Development, Cardiovascular, Renal, and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden (A.M.L., C.D.S.)

Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas (R.D.T.)

Department of Renal Medicine, University College London, London, United Kingdom (D.C.W.)

Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands, and The George Institute for Global Health, Sydney, New South Wales, Australia (H.J.L.H.).

Presented in part at Kidney Week 2022, American Society of Nephrology Annual Meeting, Orlando, Florida, 4 November 2022.

Note: All authors reviewed the manuscript drafts, approved the final version for submission, and take responsibility for the accuracy and integrity of the data. Dr. Schechter and Prof. Heerspink had full access to the data and had final responsibility for the decision to submit the manuscript for publication.

Acknowledgment: The authors thank all of the investigators, trial teams, and patients for their participation in the trial. They also thank Nicola Truss (inScience Communications, London, United Kingdom) for assistance with the editing of the draft report and preparation of the figures (support funded by AstraZeneca).

Financial Support: By AstraZeneca.

Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M22-2115.

Data Sharing Statement: Data underlying the findings described in this manuscript may be obtained upon publication in accordance with AstraZeneca's data sharing policy (https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure).

Corresponding Author: Hiddo J.L. Heerspink, PhD, Department of Clinical Pharmacy and Pharmacology, University of Groningen, Hanzeplein 1, PO Box 30 001, Groningen, the Netherlands; e-mail, .

Author Contributions: Conception and design: M. Schechter, G.M. Chertow, R. Correa-Rotter, P. Rossing, A.M. Langkilde, C.D. Sjöström, R.D. Toto, D.C. Wheeler, H.J.L. Heerspink.

Analysis and interpretation of the data: M. Schechter, N. Jongs, G.M. Chertow, O. Mosenzon, J.J.V. McMurray, R. Correa-Rotter, P. Rossing, A.M. Langkilde, C.D. Sjöström, R.D. Toto, D.C. Wheeler, H.J.L. Heerspink.

Drafting of the article: M. Schechter, N. Jongs, H.J.L. Heerspink.

Critical revision for important intellectual content: M. Schechter, N. Jongs, G.M. Chertow, O. Mosenzon, J.J.V. McMurray, R. Correa-Rotter, P. Rossing, A.M. Langkilde, C.D. Sjöström, R.D. Toto, D.C. Wheeler, H.J.L. Heerspink.

Final approval of the article: M. Schechter, N. Jongs, G.M. Chertow, O. Mosenzon, J.J.V. McMurray, R. Correa-Rotter, P. Rossing, A.M. Langkilde, C.D. Sjöström, R.D. Toto, D.C. Wheeler, H.J.L. Heerspink.

Statistical expertise: M. Schechter, N. Jongs.

This article was published at Annals.org on 6 December 2022.

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