Synergistic Effect and Mechanism of Apoptosis Induction by Morphine and the HIV-1gp120V3 Loop in Hippocampal Neurons

Agoglia AE, Sharko AC, Psilos KE, Holstein SE, Reid GT, Hodge CW (2015) Alcohol alters the activation of ERK1/2, a functional regulator of binge alcohol drinking in adult C57BL/6J mice. Alcohol Clin Exp Res 39(3):463–475. https://doi.org/10.1111/acer.12645

Alessandrini A, Namura S, Moskowitz MA, Bonventre JV (1999) MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia. Proc Natl Acad Sci USA 96(22):12866–12869. https://doi.org/10.1073/pnas.96.22.12866

Altice FL, Bruce RD, Lucas GM, Lum PJ, Korthuis PT, Flanigan TP, Cunningham CO, Sullivan LE, Vergara-Rodriguez P, Fiellin DA, Cajina A, Botsko M, Nandi V, Gourevitch MN, Finkelstein R, BHIVES Collaborative (2011) HIV treatment outcomes among HIV-infected, opioid-dependent patients receiving buprenorphine/naloxone treatment within HIV clinical care settings: results from a multisite study. J Acquir Immune Defic Syndr 56(supp1):S22–32. https://doi.org/10.1097/QAI.0b013e318209751e

Atici S, Cinel L, Cinel I, Doruk N, Aktekin M, Akca A, Handan C, Ugur O (2004) Opioid neurotoxicity: comparison of Morphine and tramadol in an experimental rat model. Int J Neurosci 114(8): 1001–1011. https://doi.org/10.1080/00207450490461314

Bachis A, Biggio F, Major EO, Mocchetti I (2009) M- and T-tropic HIVs promote apoptosis in rat neurons. J Neuroimmune Pharmacol: the official journal of the Society on Neuroimmune Pharmacol 4(1):150–160. https://doi.org/10.1007/s11481-008-9141-3

Article  Google Scholar 

Barry U, Zuo Z (2005) Opioids: old drugs for potential new applications. Curr Pharm Des 11(10): 1343–1350. https://doi.org/10.2174/1381612053507459

Byrd DA, Fellows RP, Morgello S, Franklin D, Heaton RK, Deutsch R, Atkinson JH, Clifford DB, Collier AC, Marra CM, Gelman B, McCutchan JA, Duarte NA, Simpson DM, McArthur J, Grant I, CHARTER Group (2011) Neurocognitive impact of substance use in HIV infection. J Acquir Immune Defic Syndr 58(2):154–162. https://doi.org/10.1097/QAI.0b013e318229ba41

Catani MV, Corasaniti MT, Navarra M, Nistico G, Finazzi-Agro A, Melino G (2000) gp120 induces cell death in human neuroblastoma cells through the CXCR4 and CCR5 chemokine receptors. J Neurochem 74(6):2373–2379. https://doi.org/10.1046/j.1471-4159.2000.0742373.x

Chen G, Liu S, Pan R, Li G, Tang H, Jiang M, Xing Y, Jin F, Lin L, Dong J (2018) Curcumin Attenuates gp120-Induced Microglial Inflammation by Inhibiting Autophagy via the PI3K Pathway. Cell Mol Neurobiol 38(8):1465–1477. https://doi.org/10.1007/s10571-018-0616-3

Article  CAS  PubMed  Google Scholar 

Chen X, Kirby LG, Palma J, Benamar K, Geller EB, Eisenstein TK, Adler MW (2011) The effect of gp120 on morphine’s antinociceptive and neurophysiological actions. Brain Behav Immun 25(7):1434–1443. https://doi.org/10.1016/j.bbi.2011.04.014

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chilunda V, Calderon TM, Martinez-Aguado P, Berman JW (2019) The impact of substance abuse on HIV-mediated neuropathogenesis in the current ART era. Brain Res 1724:146426. https://doi.org/10.1016/j.brainres.2019.146426

Cunningham CO (2018) Opioids and HIV Infection: From Pain Management to Addiction Treatment. Top Antivir Med 25(4):143–146

PubMed  PubMed Central  Google Scholar 

Deng Q, Huang T, Tang H, Zhong X, Xia S, Wei X, Dong J (2011) Curcumin protects against interleukin-6-induced rapid Ca2+ influx in rat hippocampal neurons. Neural Regen Res 6(24):1850–1854. https://doi.org/10.3969/j.issn.1673-5374.2011.24.002

Dutta R, Roy S (2012) Mechanism(s) involved in opioid drug abuse modulation of HAND. Curr HIV Res 10(5):469–477. https://doi.org/10.2174/157016212802138805

Gannon P, Khan MZ, Kolson DL (2011) Current understanding of HIV-associated neurocognitive disorders pathogenesis. Curr Opin Neurol 24(3):275–283. https://doi.org/10.1097/WCO.0b013e32834695fb

Gong Z, Yang L, Tang H, Pan R, Xie S, Guo L, Wang J, Deng Q, Xiong G, Xing Y, Dong J (2012) Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats. Neural Regen Res 7(3):171–175. https://doi.org/10.3969/j.issn.1673-5374.2012.03.002

Gurwell JA, Nath A, Sun Q, Zhang J, Martin KM, Chen Y, Hauser KF (2001) Synergistic neurotoxicity of opioids and human immunodeficiency virus-1 Tat protein in striatal neurons in vitro. Neuroscience 102(3):555–63. https://doi.org/10.1016/s0306-4522(00)00461-9

Heinisch S, Palma J, Kirby LG (2011) Interactions between chemokine and mu-opioid receptors: anatomical findings and electrophysiological studies in the rat periaqueductal grey. Brain Behav Immun 25(2):360–372. https://doi.org/10.1016/j.bbi.2010.10.020

Hu S, Sheng WS, Lokensgard JR, Peterson PK (2005) Morphine potentiates HIV-1 gp120-induced neuronal apoptosis. J Infect Dis 191(6):886–889. https://doi.org/10.1086/427830

Hu G, Yao H, Chaudhuri AD, Duan M, Yelamanchili SV, Wen H, Cheney PD, Fox HS, Buch S (2012) Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and Morphine-mediated neuronal dysfunction. Cell Death Dis 3:e381. https://doi.org/10.1038/cddis.2012.114

Ji J, Yu Y, Li ZL, Chen MY, Deng R, Huang X, Wang GF, Zhang MX, Yang Q, Ravichandran S, Feng GK, Xu XL, Yang CL, Qiu MZ, Jiao L, Yang D, Zhu XF (2018) XIAP Limits Autophagic Degradation of Sox2 and Is A Therapeutic Target in Nasopharyngeal Carcinoma Stem Cells. Theranostics 8(6):1494–1510. https://doi.org/10.1016/j.jep.2019.112336

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jones MV, Bell JE, Nath A (2000) Immunolocalization of HIV envelope gp120 in HIV encephalitis with dementia. AIDS 14(17):2709-2713. https://doi.org/10.1097/00002030-200012010-00010

Kaul M, Garden GA, Lipton SA (2001) Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 410(6831):988–994. https://doi.org/10.1038/35073667

Article  CAS  PubMed  Google Scholar 

Kim HJ, Shin AH, Thayer SA (2011) Activation of cannabinoid type 2 receptors inhibits HIV-1 envelope glycoprotein gp120-induced synapse loss. Mol Pharmacol 80(3):357-366. https://doi.org/10.1124/mol.111.071647

Kim S, Hahn YK, Podhaizer EM, McLane VD, Zou S, Hauser KF, Knapp PE (2018) A central role for glial CCR5 in directing the neuropathological interactions of HIV-1 Tat and opiates. J Neuroinflammation 15(1):285. https://doi.org/10.1186/s12974-018-1320-4

Liu FF, Zhao S, Liu P, Huo SP (2019a). Influence of mTOR signaling pathway on ketamine-induced injuries in the hippocampal neurons of rats. Neurol Res 41(1):77–86. https://doi.org/10.1080/01616412.2018.1531203

Liu L, Zhu J, Zhou L, Wan L (2016) RACK1 promotes maintenance of Morphine-associated memory via activation of an ERK-CREB dependent pathway in hippocampus. Sci Report 6,20183. https://doi.org/10.1038/srep20183

Liu WG, Han LL, Xiang R (2019b) Protection of miR-19b in hypoxia/reoxygenation-induced injury by targeting PTEN. J Cell Physiol. https://doi.org/10.1002/jcp.28286. Advance Online Publication

Malik S, Saha R, Seth P (2014) Involvement of extracellular signal-regulated kinase (ERK1/2)-p53-p21 axis in mediating neural stem/progenitor cell cycle arrest in co-morbid HIV-drug abuse exposure. J Neuroimmune Pharmacol 9(3):340-353. https://doi.org/10.1007/s11481-014-9523-7

Maragos WF, Young KL, Turchan JT, Guseva M, Pauly JR, Nath A, Cass WA (2002) Human immunodeficiency virus-1 Tat protein and methamphetamine interact synergistically to impair striatal dopaminergic function. J Neurochem 83(4):955–963. https://doi.org/10.1046/j.1471-4159.2002.01212.x

Martin-Thormeyer EM, Paul RH (2009) Drug abuse and hepatitis C infection as comorbid features of HIV associated neurocognitive disorder: neurocognitive and neuroimaging features. Neuropsychol Rev 19(2):215–231. https://doi.org/10.1007/s11065-009-9101-6

Meucci O, Miller RJ (1996) gp120-induced neurotoxicity in hippocampal pyramidal neuron cultures: protective action of TGF-beta1. J Neurosci 16(13):4080-4088. https://doi.org/10.1523/JNEUROSCI.16-13-04080.1996

Mocchetti I, Bachis A, Avdoshina V (2012) Neurotoxicity of human immunodeficiency virus-1: viral proteins and axonal transport. Neurotox Res 21(1):79–89. https://doi.org/10.1007/s12640-011-9279-2

Nath A, Geiger J (1998) Neurobiological aspects of human immunodeficiency virus infection: neurotoxic mechanisms. Prog Neurobiol 54(1): 19–33. https://doi.org/10.1016/s0301-0082(97)00053-1

NIH U.S. National Library of Medicine (2020) [Website]. Available from: www.clinicaltrials.gov Accessed 6 May 2020

Nookala AR, Schwartz DC, Chaudhari NS, Glazyrin A, Stephens EB, Berman N, Kumar A (2018) Methamphetamine augment HIV-1 Tat mediated memory deficits by altering the expression of synaptic proteins and neurotrophic factors. Brain Behav Immun 71:37–51. https://doi.org/10.1016/j.bbi.2018.04.018

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park JH, Kim BH, Park SJ, Jin JK, Jeon YC, Wen GY, Shin HY, Carp RI, Kim YS (2011) Association of endothelial nitric oxide synthase and mitochondrial dysfunction in the hippocampus of scrapie-infected mice. Hippocampus 21(3):319–333. https://doi.org/10.1002/hipo.20753

Paris JJ, Liere P, Kim S, Mahdi F, Buchanan ME, Nass SR, Qrareya AN, Salahuddin MF, Pianos A, Fernandez N, Shariat-Madar Z, Knapp PE, Schumacher M, Hauser KF (2020) Pregnane steroidogenesis is altered by HIV-1 Tat and morphine: Physiological allopregnanolone is protective against neurotoxic and psychomotor effects. Neurobiol Stress 12:100211. https://doi.org/10.1016/j.ynstr.2020.100211

Peng F, Dhillon NK, Yao H, Zhu X, Williams R, Buch S (2008) Mechanisms of platelet-derived growth factor-mediated neuroprotection--implications in HIV dementia. Eur J Neurosci 28(7):1255–1264. https://doi.org/10.1111/j.1460-9568.2008.06444.x

Petito CK, Roberts B, Cantando JD, Rabinstein A, Duncan R (2001) Hippocampal injury and alterations in neuronal chemokine co-receptor expression in patients with AIDS. J Neuropathol Exp Neurol 60(4):377-385. https://doi.org/10.1093/jnen/60.4.377

Podhaizer EM, Zou S, Fitting S, Samano KL, El-Hage N, Knap PE, Hauser KF (2012) Morphine and gp120 toxic interactions in striatal neuron are dependent on HIV-1 strain. J Neuroimmune Pharmacol 7(4):877–891. https://doi.org/10.1007/s11481-011-9326-z

Purohit V, Rapaka R, Shurtleff D (2011) Drugs of abuse, dopamine, and HIV-associated neurocognitive disorders/HIV-associated dementia. Mol Neurobiol 44(1):102–110. https://doi.org/10.1007/s12035-011-8195-z

Rezaei F, Saebipour MR, Ghaemi K, Hassanzadeh-Taheri MM, Foadoddini M, Hosseini M (2020) Intra-cerebroventricular Administration of Crocin Attenuates Sleep Deprivation-induced Hyperalgesia in Rats. Basic Clin Neurosci 11(3):261–267. https://doi.org/10.32598/bcn.11.2.144.3

Salvioli S, Ardizzoni A, Franceschi C, Cossarizza A (1997) JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis. FEBS Lett 411(1):77-82. https://doi.org/10.1016/S0014-5793(97)00669

Saylor Deanna, Dickens Alex M, Sacktor Ned, Haughey Norman, Slusher Barbara, Pletnikov Mikhail, Mankowski Joseph L, Brown Amanda, Volsky David J, McArthur Justin C (2016) HIV-associated neurocognitive disorder–pathogenesis and prospects for treatment. Nat Rev Neurol 12 (4):234–248. https://doi.org/10.1038/nrneurol.2016.53

Shi Y, Yuan S, Tang SJ (2020) Reactive Oxygen Species (ROS) are Critical for Morphine Exacerbation of HIV-1 gp120-Induced Pain. J Neuroimmune Pharmacol: the official journal of the Society on Neuroimmune Pharmacol. https://doi.org/10.1007/s11481-020-09951-6

Article  Google Scholar 

Shibata S, Tominaga K, Watanabe S (1995) kappa-Opioid receptor agonist protects against ischemic reduction of 2-deoxyglucose uptake in Morphine-tolerant rats. Eur J Pharmacol 279(2–3):197–202. https://doi.org/10.1016/0014-2999(95)00152-b

Spudich S, González-Scarano F (2012) HIV-1-related central nervous system disease: current issues in pathogenesis, diagnosis, and treatment. Cold Spring Harbor Perspect Med 2(6):a007120. https://doi.org/10.1101/cshperspect.a007120

Article  CAS  Google Scholar 

Sun WL., Quizon PM., Zhu J (2016) Molecular Mechanism: ERK Signaling, Drug Addiction, and Behavioral Effects. Prog Mol Biol Transl Sci 137:1–40. https://doi.org/10.1016/bs.pmbts.2015.10.017

Takashima A (2006) GSK-3 is essential in the pathogenesis of Alzheimer's disease. J Alzheimers Dis. 9(3 Suppl):309–317. https://doi.org/10.3233/jad-2006-9s335

Takahashi K, Yi H, Liu CH, Liu S, Kashiwagi Y, Patin DJ, Hao S (2018) Spinal bromodomain-containing protein 4 contributes to neuropathic pain induced by HIV glycoprotein 120 with morphine in rats. NeuroReport 29(6):441–446. https://doi.org/10.1097/WNR.0000000000000992

Article  CAS  PubMed  Google Scholar 

Tang H, Lu D, Pan R, Qin X, Xiong H, Dong J (2009) Curcumin improves spatial memory impairment induced by human immunodeficiency virus type 1 glycoprotein 120 V3 loop peptide in rats. Life Sci 85(1–2):1–10. https://doi.org/10.1016/j.lfs.2009.03.013

Tang H, Pan R, Fang W, Xing Y, Chen D, Chen X, Yu Y, Wang J, Gong Z, Xiong G, Dong J (2013) Curcumin ameliorates hippocampal neuron damage induced by human immunodeficiency virus-1. Neural Regen Res 8(15):1368–1375. https://doi.org/10.3969/j.issn.1673-5374.2013.15.003

Toggas SM, Masliah E, Rockenstein EM, Rall GF, Abraham CR, Mucke L (1994) Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature 367(6459):188–193. https://doi.org/10.1038/367188a0

UNAIDS (2018) 2017 GLOBAL HIV STATISTICS. [Website]. Available from: http://aidsinfo.unaids.org/

Vicario-Abejon C (2004) Long-term culture of hippocampal neurons. Curr Protoc Neurosci Chapter 3: Unit 3. https://doi.org/10.1002/0471142301.ns0302s26

Wang JK, Guo Q, Zhang XW, Wang LC, Liu Q, Tu PF, Jiang Y, Zeng KW (2020) Aglaia odorata Lour. extract inhibit ischemic neuronal injury potentially via suppressing p53/Puma-mediated mitochondrial apoptosis pathway. J Ethnopharmacol 248:112336. https://doi.org/10.1016/j.jep.2019.112336

Yao R, Cooper GM. (1995) Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267(5206):2003-2006. https://doi.org/10.1126/science.7701324

Zhou Y, Liu J, Xiong H (2017) HIV-1 Glycoprotein 120 Enhancement of N-Methyl-D-Aspartate NMDA Receptor-Mediated Excitatory Postsynaptic Currents: Implications for HIV-1-Associated Neural Injury. J Neuroimmune Pharmacol: the official journal of the Society on Neuroimmune Pharmacol 12(2):314–326. https://doi.org/10.1007/s11481-016-9719-0

Article  Google Scholar 

留言 (0)

沒有登入
gif