Available online 5 December 2022, 100617
Author links open overlay panelAbstractIntroductionThe prevalence of diabetes mellitus is increasing rapidly worldwide and blood glucose tight control is essential for reducing mortality and morbidity. To date, several herbal medicines have been used in the management of diabetes. The present study evaluated the effect of a commercially available capsule in Iran, Viabet® in patients with type 2 diabetes.
MethodsThis randomized, triple-blind, placebo-controlled clinical trial was conducted on thirty diabetic patients who referred to the Ghaem Hospital endocrine clinic in Mashhad, Iran, who fulfilled the inclusion criteria. The participants randomly received 500 mg Viabet® capsules containing Trigonella foenum-graecum, Urtica dioica Cinnamomum cassia, Stevia rebaudiana and Cyamopsis tetragonoloba (L.) Taub. (Fabaceae)or the placebo three times daily for three months. Fasting blood sugar (FBS) and weight were assessed monthly and glycated hemoglobin (HbA1C) and lipid profile at the beginning and the end of treatment. The data were analyzed with SPSS version 16 software.
ResultsFBS did not significantly change within or between the groups whereas HbA1C reduced considerably in the treatment group after three months (P=0.03). Also, noticeable weight loss was observed in the treatment group (P = 0.001), although it was not significant in the monthly evaluation in comparison with the controls. Furthermore, evaluation of lipid profile in both groups did not indicate meaningful variations. In case of safety, no considerable adverse reactions were reported.
ConclusionsUsing Viabet® thrice daily for three months was not significantly effective on FBS and HbA1C in comparison with the placebo group. Further studies on this supplement are needed for better judgment.
Abbreviations2-hpp2 hour post prandial
ALTAlanine aminotransferase
ASTAspartate aminotransferase
BMP4bone morphogenetic protein 4
FIRIfasting insulin resistance index
FOXP2forkhead box protein 2
GLUT4glucose transporter 4
HDL-chigh density lipoprotein cholesterol
HOMA-IRhomeostatic model assessment for insulin resistance
LDL-clow density lipoprotein Cholesterol
OGTTOral glucose tolerance test
PPARγperoxisome proliferator activated receptor gamma
T2DMtype 2 diabetes mellitus
VLDL-CVery Low Density Lipoprotein Cholesterol
KeyWordsNettle
Fenugreek
Cinnamon
Stevia
Aconite bean
Diabetes mellitus type 2
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