Arfanakis K, Evia AM, Leurgans SE, Cardoso LFC, Kulkarni A, Alqam N et al (2020) Neuropathologic correlates of white matter hyperintensities in a community-based cohort of older adults. J Alzheimers Dis 73:333–345. https://doi.org/10.3233/JAD-190687

Article  Google Scholar 

Arvanitakis Z, Capuano AW, Lamar M, Shah RC, Barnes LL, Bennett DA et al (2018) Late-life blood pressure association with cerebrovascular and Alzheimer disease pathology. Neurology 91:e517–e525. https://doi.org/10.1212/WNL.0000000000005951

Article  Google Scholar 

Banerjee G, Kim HJ, Fox Z, Jäger HR, Wilson D, Charidimou A et al (2017) MRI-visible perivascular space location is associated with Alzheimer’s disease independently of amyloid burden. Brain 140:1107–1116. https://doi.org/10.1093/brain/awx003

Article  Google Scholar 

Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc Ser B (Methodol) 57:289–300. https://doi.org/10.1111/j.2517-6161.1995.tb02031.x

Article  Google Scholar 

Bennett DA, Buchman AS, Boyle PA, Barnes LL, Wilson RS, Schneider JA (2018) Religious orders study and rush Memory and Aging Project. J Alzheimers Dis 64:S161–S189. https://doi.org/10.3233/JAD-179939

Article  Google Scholar 

Bennett DA, Schneider JA, Buchman AS, Barnes LL, Boyle PA, Wilson RS (2012) Overview and findings from the rush Memory and Aging Project. Curr Alzheimer Res 9:646–663. https://doi.org/10.2174/156720512801322663

Article  CAS  Google Scholar 

Blanco PJ, Müller LO, Spence JD (2017) Blood pressure gradients in cerebral arteries: a clue to pathogenesis of cerebral small vessel disease. Stroke Vasc Neurol 2:108–117. https://doi.org/10.1136/svn-2017-000087

Article  Google Scholar 

Blevins BL, Vinters HV, Love S, Wilcock DM, Grinberg LT, Schneider JA et al (2021) Brain arteriolosclerosis. Acta Neuropathol 141:1–24. https://doi.org/10.1007/s00401-020-02235-6

Article  Google Scholar 

Bordes C, Sargurupremraj M, Mishra A, Debette S (2022) Genetics of common cerebral small vessel disease. Nat Rev Neurol 18:84–101. https://doi.org/10.1038/s41582-021-00592-8

Article  Google Scholar 

Buchman AS, Capuano AW, VanderHorst V, Wilson RS, Oveisgharan S, Schneider JA et al (2021) Brain β-amyloid links the association of change in BMI with cognitive decline in community-dwelling older adults. J Gerontol A Biol Sci Med Sci. https://doi.org/10.1093/gerona/glab320

Article  Google Scholar 

Buchman AS, Leurgans SE, Nag S, VanderHorst V, Kapasi A, Schneider JA et al (2017) Spinal arteriolosclerosis is common in older adults and associated with parkinsonism. Stroke 48:2792–2798. https://doi.org/10.1161/STROKEAHA.117.017643

Article  Google Scholar 

Buchman AS, Leurgans SE, VanderHorst VGJM, Nag S, Schneider JA, Bennett DA (2019) Spinal motor neurons and motor function in older adults. J Neurol 266:174–182. https://doi.org/10.1007/s00415-018-9118-y

Article  Google Scholar 

Evans TE, Knol MJ, Schwingenschuh P, Wittfeld K, Hilal S, Ikram MA et al (2022) Determinants of perivascular spaces in the general population: a pooled cohort analysis of individual participant data. Neurology. https://doi.org/10.1212/WNL.0000000000201349.10.1212/WNL.0000000000201349

Article  Google Scholar 

Fugate JE, Rabinstein AA (2015) Posterior reversible encephalopathy syndrome: clinical and radiological manifestations, pathophysiology, and outstanding questions. Lancet Neurol 14:914–925. https://doi.org/10.1016/S1474-4422(15)00111-8

Article  Google Scholar 

Gailloud P (2019) Spinal vascular anatomy. Neuroimaging Clin N Am 29:615–633. https://doi.org/10.1016/j.nic.2019.07.007

Article  Google Scholar 

Gao Y, Li D, Lin J, Thomas AM, Miao J, Chen D et al (2022) Cerebral small vessel disease: pathological mechanisms and potential therapeutic targets. Front Aging Neurosci 14:961661. https://doi.org/10.3389/fnagi.2022.961661

Article  CAS  Google Scholar 

Ge S, Pachter JS (2006) Isolation and culture of microvascular endothelial cells from murine spinal cord. J Neuroimmunol 177:209–214. https://doi.org/10.1016/j.jneuroim.2006.05.012

Article  CAS  Google Scholar 

Grinberg LT, Thal DR (2010) Vascular pathology in the aged human brain. Acta Neuropathol 119:277–290. https://doi.org/10.1007/s00401-010-0652-7

Article  Google Scholar 

Hachinski V, Østergaard L (2021) The ambibaric brain: pathophysiological and clinical implications. Stroke 52:e259–e262. https://doi.org/10.1161/STROKEAHA.120.033492

Article  CAS  Google Scholar 

Hainsworth AH, Oommen AT, Bridges LR (2015) Endothelial cells and human cerebral small vessel disease. Brain Pathol 25:44–50. https://doi.org/10.1111/bpa.12224

Article  CAS  Google Scholar 

Hyman BT, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Carrillo MC et al (2012) National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease. Alzheimers Dement 8:1–13. https://doi.org/10.1016/j.jalz.2011.10.007

Article  Google Scholar 

Ighodaro ET, Abner EL, Fardo DW, Lin A-L, Katsumata Y, Schmitt FA et al (2017) Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals. J Cereb Blood Flow Metab 37:201–216. https://doi.org/10.1177/0271678X15621574

Article  CAS  Google Scholar 

Javierre-Petit C, Schneider JA, Kapasi A, Makkinejad N, Tamhane AA, Leurgans SE et al (2020) Neuropathologic and cognitive correlates of enlarged perivascular spaces in a community-based cohort of older adults. Stroke 51:2825–2833. https://doi.org/10.1161/STROKEAHA.120.029388

Article  Google Scholar 

Kapasi A, Yu L, Petyuk V, Arfanakis K, Bennett DA, Schneider JA (2022) Association of small vessel disease with tau pathology. Acta Neuropathol 143:349–362. https://doi.org/10.1007/s00401-021-02397-x

Article  CAS  Google Scholar 

Kivipelto M, Ngandu T, Laatikainen T, Winblad B, Soininen H, Tuomilehto J (2006) Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study. Lancet Neurol 5:735–741. https://doi.org/10.1016/S1474-4422(06)70537-3

Article  Google Scholar 

Lam MA, Hemley SJ, Najafi E, Vella NGF, Bilston LE, Stoodley MA (2017) The ultrastructure of spinal cord perivascular spaces: implications for the circulation of cerebrospinal fluid. Sci Rep 7:12924. https://doi.org/10.1038/s41598-017-13455-4

Article  CAS  Google Scholar 

Li Y, Tong CH, Rowland CM, Radcliff J, Bare LA, McPhaul MJ et al (2021) Association of changes in lipid levels with changes in vitamin D levels in a real-world setting. Sci Rep 11:21536. https://doi.org/10.1038/s41598-021-01064-1

Article  CAS  Google Scholar 

Liu N, Xue Y, Tang J, Zhang M, Ren X, Fu J (2021) The dynamic change of phenotypic markers of smooth muscle cells in an animal model of cerebral small vessel disease. Microvasc Res 133:104061. https://doi.org/10.1016/j.mvr.2020.104061

Article  CAS  Google Scholar 

Makkinejad N, Evia AM, Tamhane AA, Javierre-Petit C, Leurgans SE, Lamar M et al (2021) ARTS: a novel in-vivo classifier of arteriolosclerosis for the older adult brain. Neuroimage Clin 31:102768. https://doi.org/10.1016/j.nicl.2021.102768

Article  Google Scholar 

Medi-Span (1995) Master drug data base documentation manual. Medi-Span, Indianapolis

Google Scholar 

Nelson JW, Phillips SC, Ganesh BP, Petrosino JF, Durgan DJ, Bryan RM (2021) The gut microbiome contributes to blood–brain barrier disruption in spontaneously hypertensive stroke prone rats. FASEB J 35:e21201. https://doi.org/10.1096/fj.202001117R

Article  CAS  Google Scholar 

Oveisgharan S, Arvanitakis Z, Yu L, Farfel J, Schneider JA, Bennett DA (2018) Sex differences in Alzheimer’s disease and common neuropathologies of aging. Acta Neuropathol 136:887–900. https://doi.org/10.1007/s00401-018-1920-1

Article  CAS  Google Scholar 

Oveisgharan S, Capuano AW, Kapasi A, Buchman AS, Schneider JA, Bennett DA et al (2020) Association of low systolic blood pressure with postmortem amyloid-β and tau. J Alzheimers Dis 78:1755–1764. https://doi.org/10.3233/JAD-200412

Article  CAS  Google Scholar 

Oveisgharan S, Capuano AW, Nag S, Agrawal S, Barnes LL, Bennett DA et al (2021) Association of hemoglobin A1C with TDP-43 pathology in community-based elders. Neurology 96:e2694–e2703. https://doi.org/10.1212/WNL.0000000000012025

Article  CAS  Google Scholar 

Oveisgharan S, Yu L, Barnes LL, Agrawal S, Schneider JA, Bennett DA et al (2022) Association of statins with cerebral atherosclerosis and incident parkinsonism in older adults. Neurology. https://doi.org/10.1212/WNL.0000000000200182.10.1212/WNL.0000000000200182

Article  Google Scholar 

Oveisgharan S, Yu L, Capuano A, Arvanitakis Z, Barnes LL, Schneider JA et al (2021) Late-life vascular risk score in association with postmortem cerebrovascular disease brain pathologies. Stroke 52:2060–2067. https://doi.org/10.1161/STROKEAHA.120.030226

Article  CAS  Google Scholar 

Oveisgharan S, Yu L, Poole VN, Evia AM, Barnes LL, Schneider JA et al (2021) Association of white matter hyperintensities with pathology and progression of parkinsonism in aging. JAMA Neurol 78:1494–1502. https://doi.org/10.1001/jamaneurol.2021.3996

Article  Google Scholar 

Pirie K, Peto R, Reeves GK, Green J, Beral V, Million Women Study Collaborators (2013) The 21st century hazards of smoking and benefits of stopping: a prospective study of one million women in the UK. Lancet 381:133–141. https://doi.org/10.1016/S0140-6736(12)61720-6

Article  Google Scholar 

Ros Castelló V, Sánchez Sánchez A, Natera Villalba E, Gómez López A, Parra P, Rodríguez Jorge F et al (2021) Spinal cord infarction: aetiology, imaging findings, and prognostic factors in a series of 41 patients. Neurologia (Engl Ed) S2173–5808(21):00077–00078. https://doi.org/10.1016/j.nrleng.2020.11.004

Article  Google Scholar 

Schober P, Boer C, Schwarte LA (2018) Correlation coefficients: appropriate use and interpretation. Anesth Analg 126:1763–1768. https://doi.org/10.1213/ANE.0000000000002864

Article  Google Scholar 

Singer JEW, John B (2003) Applied longitudinal data analysis: Modeling change and event occurrence. Oxford University Press, New York

Book  Google Scholar 

Skrobot OA, Attems J, Esiri M, Hortobágyi T, Ironside JW, Kalaria RN et al (2016) Vascular cognitive impairment neuropathology guidelines (VCING): the contribution of cerebrovascular pathology to cognitive impairment. Brain 139:2957–2969. https://doi.org/10.1093/brain/aww214

Article  Google Scholar 

Spence JD (2019) Blood pressure gradients in the brain: their importance to understanding pathogenesis of cerebral small vessel disease. Brain Sci 9:E21. https://doi.org/10.3390/brainsci9020021

Article  CAS