Henquin JC, Dufrane D, Nenquin M (2006) Nutrient control of insulin secretion in isolated normal human islets. Diabetes 55(12):3470–3477. https://doi.org/10.2337/db06-0868
Article CAS PubMed Google Scholar
Henquin JC, Dufrane D, Kerr-Conte J, Nenquin M (2015) Dynamics of glucose-induced insulin secretion in normal human islets. Am J Physiol Endocrinol Metab 309(7):E640–E650. https://doi.org/10.1152/ajpendo.00251.2015
Article CAS PubMed Google Scholar
Rorsman P, Ashcroft FM (2018) Pancreatic β-cell electrical activity and insulin secretion: Of mice and men. Physiol Rev 98(1):117–214. https://doi.org/10.1152/physrev.00008.2017
Article CAS PubMed Google Scholar
Henquin JC (2009) Regulation of insulin secretion: a matter of phase control and amplitude modulation. Diabetologia 52(5):739–751. https://doi.org/10.1007/s00125-009-1314-y
Article CAS PubMed Google Scholar
Rahier J, Guiot Y, Goebbels RM, Sempoux C, Henquin JC (2008) Pancreatic β-cell mass in European subjects with type 2 diabetes. Diabetes Obes Metab 10(Suppl 4):32–42. https://doi.org/10.1111/j.1463-1326.2008.00969.x
Turner RC, Cull CA, Frighi V, Holman RR (1999) Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. JAMA 281(21):2005–2012. https://doi.org/10.1001/jama.281.21.2005
Article CAS PubMed Google Scholar
Andersson A, Hellerstrom C (1972) Metabolic characteristics of isolated pancreatic islets in tissue culture. Diabetes 21(2 Suppl):546–554. https://doi.org/10.2337/diab.21.2.s546
Article CAS PubMed Google Scholar
Poitout V, Robertson RP (2008) Glucolipotoxicity: fuel excess and β-cell dysfunction. Endocr Rev 29(3):351–366. https://doi.org/10.1210/er.2007-0023
van Raalte DH, Diamant M (2011) Glucolipotoxicity and beta cells in type 2 diabetes mellitus: target for durable therapy? Diabetes Res Clin Pract 93(Suppl 1):S37–S46. https://doi.org/10.1016/S0168-8227(11)70012-2
Article CAS PubMed Google Scholar
Bensellam M, Laybutt DR, Jonas JC (2012) The molecular mechanisms of pancreatic beta-cell glucotoxicity: Recent findings and future research directions. Mol Cell Endocrinol 364(1-2):1–27. https://doi.org/10.1016/j.mce.2012.08.003
Article CAS PubMed Google Scholar
Prentki M, Peyot ML, Masiello P, Murthy Madiraju SR (2020) Nutrient-induced metabolic stress, adaptation, detoxification, and toxicity in the pancreatic β-cell. Diabetes 69(3):279–290. https://doi.org/10.2337/dbi19-0014
Article CAS PubMed Google Scholar
Lytrivi M, Castell AL, Poitout V, Cnop M (2020) Recent insights into mechanisms of β-cell lipo- and glucolipotoxicity in type 2 diabetes. J Mol Biol 432(5):1514–1534. https://doi.org/10.1016/j.jmb.2019.09.016
Article CAS PubMed Google Scholar
Weir GC (2020) Glucolipotoxicity, beta-cells, and diabetes: the emperor has no clothes. Diabetes 69(3):273–278. https://doi.org/10.2337/db19-0138
Article CAS PubMed PubMed Central Google Scholar
Dai C, Kayton NS, Shostak A et al (2016) Stress-impaired transcription factor expression and insulin secretion in transplanted human islets. J Clin Invest 126(5):1857–1870. https://doi.org/10.1172/JCI83657
Article PubMed PubMed Central Google Scholar
Marselli L, Piron A, Suleiman M et al (2020) Persistent or transient human β cell dysfunction induced by metabolic stress: specific signatures and shared gene expression with type 2 diabetes. Cell Rep 33(9):108466–108466. https://doi.org/10.1016/j.celrep.2020.108466
Article CAS PubMed Google Scholar
Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R (2011) Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia 54(10):2506–2514. https://doi.org/10.1007/s00125-011-2204-7
Article CAS PubMed PubMed Central Google Scholar
Taylor R, Al-Mrabeh A, Zhyzhneuskaya S et al (2018) Remission of human type 2 diabetes requires decrease in liver and pancreas fat content but is dependent upon capacity for beta cell recovery. Cell Metab 28(4):547–556; e541-e543. https://doi.org/10.1016/j.cmet.2018.07.003
Article CAS PubMed Google Scholar
de Souza AH, Santos LRB, Roma LP, Bensellam M, Carpinelli AR, Jonas JC (2017) NADPH oxidase-2 does not contribute to beta-cell glucotoxicity in cultured pancreatic islets from C57BL/6J mice. Mol Cell Endocrinol 439:354–362. https://doi.org/10.1016/j.mce.2016.09.022
Article CAS PubMed Google Scholar
Roma LP, Jonas JC (2020) Nutrient metabolism, subcellular redox state, and oxidative stress in pancreatic islets and beta-cells. J Mol Biol 432(5):1461–1493. https://doi.org/10.1016/j.jmb.2019.10.012
Article CAS PubMed Google Scholar
Detimary P, Jonas JC, Henquin JC (1996) Stable and diffusible pools of nucleotides in pancreatic islet cells. Endocrinology 137(11):4671–4676. https://doi.org/10.1210/endo.137.11.8895332
Article CAS PubMed Google Scholar
Khaldi MZ, Guiot Y, Gilon P, Henquin JC, Jonas JC (2004) Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose. Am J Physiol Endocrinol Metab 287(2):E207–E217. https://doi.org/10.1152/ajpendo.00426.2003
Article CAS PubMed Google Scholar
Jaffredo M, Bertin E, Pirog A et al (2021) Dynamic uni- and multicellular patterns encode biphasic activity in pancreatic islets. Diabetes 70(4):878–888. https://doi.org/10.2337/db20-0214
Article CAS PubMed Google Scholar
Lebreton F, Pirog A, Belouah I et al (2015) Slow potentials encode intercellular coupling and insulin demand in pancreatic beta cells. Diabetologia 58(6):1291–1299. https://doi.org/10.1007/s00125-015-3558-z
Article CAS PubMed Google Scholar
Braun M, Ramracheya R, Bengtsson M et al (2008) Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion. Diabetes 57(6):1618–1628. https://doi.org/10.2337/db07-0991
Article CAS PubMed Google Scholar
Ferrannini E, Mari A (2014) beta-Cell function in type 2 diabetes. Metabolism 63(10):1217–1227. https://doi.org/10.1016/j.metabol.2014.05.012
Article CAS PubMed Google Scholar
Doliba NM, Qin W, Najafi H et al (2012) Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics. Am J Physiol Endocrinol Metab 302(1):E87–E102. https://doi.org/10.1152/ajpendo.00218.2011
Article CAS PubMed Google Scholar
Li G, Wu B, Ward MG et al (2016) Multifunctional in vivo imaging of pancreatic islets during diabetes development. J Cell Sci 129(14):2865–2875. https://doi.org/10.1242/jcs.190843
Article CAS PubMed PubMed Central Google Scholar
Brereton MF, Rohm M, Shimomura K et al (2016) Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic beta-cells. Nat Commun 7:13496. https://doi.org/10.1038/ncomms13496
Article CAS PubMed PubMed Central Google Scholar
Nagao M, Esguerra JLS, Asai A et al (2020) Potential protection against type 2 diabetes in obesity through lower CD36 expression and improved exocytosis in beta-cells. Diabetes 69(6):1193–1205. https://doi.org/10.2337/db19-0944
Article CAS PubMed PubMed Central Google Scholar
Ling Z, Pipeleers DG (1996) Prolonged exposure of human β cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation. J Clin Invest 98(12):2805–2812. https://doi.org/10.1172/JCI119108
Eizirik DL, Korbutt GS, Hellerström C (1992) Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the β-cell function. J Clin Invest 90(4):1263–1268. https://doi.org/10.1172/JCI115989
Article CAS PubMed PubMed Central Google Scholar
Bjorklund A, Lansner A, Grill VE (2000) Glucose-induced [Ca2+]i abnormalities in human pancreatic islets: important role of overstimulation. Diabetes 49(11):1840–1848. https://doi.org/10.2337/diabetes.49.11.1840
Article CAS PubMed Google Scholar
Masini M, Anello M, Bugliani M et al (2014) Prevention by metformin of alterations induced by chronic exposure to high glucose in human islet beta cells is associated with preserved ATP/ADP ratio. Diabetes Res Clin Pract 104(1):163–170. https://doi.org/10.1016/j.diabres.2013.12.031
Article CAS PubMed Google Scholar
Chareyron I, Christen S, Moco S et al (2020) Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells. Diabetologia 63(12):2628–2640. https://doi.org/10.1007/s00125-020-05275-5
Article CAS PubMed PubMed Central Google Scholar
Mir-Coll J, Moede T, Paschen M et al (2021) Human islet microtissues as an in vitro and an in vivo model system for diabetes. Int J Mol Sci 22(4):1813. https://doi.org/10.3390/ijms22041813
Article CAS PubMed PubMed Central Google Scholar
Ma Z, Wirström T, Borg LAH et al (2012) Diabetes reduces β-cell mitochondria and induces distinct morphological abnormalities, which are reproducible by high glucose in vitro with attendant dysfunction. Islets 4(3):233–242. https://doi.org/10.4161/isl.20516
留言 (0)