Enhanced AMPAR-dependent synaptic transmission by S-nitrosylation in the vmPFC contributes to chronic inflammatory pain-induced persistent anxiety in mice

Dersh J, Polatin PB, Gatchel RJ. Chronic pain and psychopathology: research findings and theoretical considerations. Psychosom Med. 2002;64:773–86.

PubMed  Google Scholar 

Price DD. Psychological and neural mechanisms of the affective dimension of pain. Science. 2000;288:1769–72.

Article  CAS  PubMed  Google Scholar 

Velly AM, Mohit S. Epidemiology of pain and relation to psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2018;87:159–67.

Article  PubMed  Google Scholar 

Bair MJ, Wu J, Damush TM, Sutherland JM, Kroenke K. Association of depression and anxiety alone and in combination with chronic musculoskeletal pain in primary care patients. Psychosom Med. 2008;70:890–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bruffaerts R, Demyttenaere K, Kessler RC, Tachimori H, Bunting B, Hu C, et al. The associations between preexisting mental disorders and subsequent onset of chronic headaches: a worldwide epidemiologic perspective. J Pain. 2015;16:42–52.

Article  PubMed  Google Scholar 

de Heer EW, Gerrits MM, Beekman AT, Dekker J, van Marwijk HW, de Waal MW, et al. The association of depression and anxiety with pain: a study from NESDA. PLoS One. 2014;9:e106907.

Article  PubMed  PubMed Central  Google Scholar 

Feingold D, Brill S, Goor-Aryeh I, Delayahu Y, Lev-Ran S. Depression and anxiety among chronic pain patients receiving prescription opioids and medical marijuana. J Affect Disord. 2017;218:1–7.

Article  PubMed  Google Scholar 

Hasanpour-Dehkordi A, Solati K, Tali SS, Dayani MA. Effect of progressive muscle relaxation with analgesic on anxiety status and pain in surgical patients. Br J Nurs. 2019;28:174–8.

Article  PubMed  Google Scholar 

Myers-Schulz B, Koenigs M. Functional anatomy of ventromedial prefrontal cortex: implications for mood and anxiety disorders. Mol Psychiatry. 2012;17:132–41.

Article  CAS  PubMed  Google Scholar 

Zhuo M. Neural mechanisms underlying anxiety-chronic pain interactions. Trends Neurosci. 2016;39:136–45.

Article  CAS  PubMed  Google Scholar 

Wang GQ, Cen C, Li C, Cao S, Wang N, Zhou Z, et al. Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety. Nat Commun. 2015;6:7660.

Article  CAS  PubMed  Google Scholar 

Liang HY, Chen ZJ, Xiao H, Lin YH, Hu YY, Chang L, et al. nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors. Nat Commun. 2020;11:2501.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hung KL, Wang SJ, Wang YC, Chiang TR, Wang CC. Upregulation of presynaptic proteins and protein kinases associated with enhanced glutamate release from axonal terminals (synaptosomes) of the medial prefrontal cortex in rats with neuropathic pain. Pain. 2014;155:377–87.

Article  CAS  PubMed  Google Scholar 

Bi LL, Wang J, Luo ZY, Chen SP, Geng F, Chen YH, et al. Enhanced excitability in the infralimbic cortex produces anxiety-like behaviors. Neuropharmacology. 2013;72:148–56.

Article  CAS  PubMed  Google Scholar 

Saitoh A, Ohashi M, Suzuki S, Tsukagoshi M, Sugiyama A, Yamada M, et al. Activation of the prelimbic medial prefrontal cortex induces anxiety-like behaviors via N-Methyl-D-aspartate receptor-mediated glutamatergic neurotransmission in mice. J Neurosci Res. 2014;92:1044–53.

Article  CAS  PubMed  Google Scholar 

Kerchner GA, Nicoll RA. Silent synapses and the emergence of a postsynaptic mechanism for LTP. Nat Rev Neurosci. 2008;9:813–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, et al. Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev. 2010;62:405–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wenthold RJ, Petralia Rs Fau - Blahos J II, Blahos J, Ii Fau - Niedzielski AS, Niedzielski AS. Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons. J Neurosci. 1996;16:1982–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

O’Brien RJ, Kamboj S, Ehlers MD, Rosen KR, Fischbach GD, Huganir RL. Activity-dependent modulation of synaptic AMPA receptor accumulation. Neuron. 1998;21:1067–78.

Article  PubMed  Google Scholar 

Penn AC, Zhang CL, Georges F, Royer L, Breillat C, Hosy E, et al. Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors. Nature. 2017;549:384–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lissin DV, Gomperts SN, Carroll RC, Christine CW, Kalman D, Kitamura M, et al. Activity differentially regulates the surface expression of synaptic AMPA and NMDA glutamate receptors. Proc Natl Acad Sci USA. 1998;95:7097–102.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Selvakumar B, Huganir RL, Snyder SH. S-nitrosylation of stargazin regulates surface expression of AMPA-glutamate neurotransmitter receptors. Proc Natl Acad Sci USA. 2009;106:16440–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang Y, Man HY, Sekine-Aizawa Y, Han Y, Juluri K, Luo H, et al. S-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors. Neuron. 2005;46:533–40.

Article  CAS  PubMed  Google Scholar 

Zhou L, Li F, Xu HB, Luo CX, Wu HY, Zhu MM, et al. Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95. Nat Med. 2010;16:1439–43.

Article  CAS  PubMed  Google Scholar 

Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, et al. The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PLoS Biol. 2020;18:e3000410.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang J, Shen YY, Li J, Lin YH, Luo CX, Zhu DY. (+)-Borneol alleviates mechanical hyperalgesia in models of chronic inflammatory and neuropathic pain in mice. Eur J Pharmacol. 2015;757:53–8.

Article  CAS  PubMed  Google Scholar 

Zhu LJ, Li TY, Luo CX, Jiang N, Chang L, Lin YH, et al. CAPON-nNOS coupling can serve as a target for developing new anxiolytics. Nat Med. 2014;20:1050–4.

Article  CAS  PubMed  Google Scholar 

Warner-Schmidt JL, Vanover KE, Chen EY, Marshall JJ, Greengard P. Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans. Proc Natl Acad Sci USA. 2011;108:9262–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma L, Yue L, Zhang Y, Wang Y, Han B, Cui S, et al. Spontaneous pain disrupts ventral hippocampal CA1-infralimbic cortex connectivity and modulates pain progression in rats with peripheral inflammation. Cell Rep. 2019;29:1579–93.

Article  CAS  PubMed  Google Scholar 

Li J, Zhang L, Xu C, Shen YY, Lin YH, Zhang Y, et al. A pain killer without analgesic tolerance designed by co-targeting PSD-95-nNOS interaction and alpha2-containning GABAARs. Theranostics. 2021;11:5970–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yin CY, Huang SY, Gao L, Lin YH, Chang L, Wu HY, et al. Neuronal nitric oxide synthase in nucleus accumbens specifically mediates susceptibility to social defeat stress through cyclin-dependent kinase 5. J Neurosci. 2021;41:2523–39.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo CX, Zhu XJ, Zhou QG, Wang B, Wang W, Cai HH, et al. Reduced neuronal nitric oxide synthase is involved in ischemia-induced hippocampal neurogenesis by up-regulating inducible nitric oxide synthase expression. J Neurochem. 2007;103:1872–82.

Article  CAS  PubMed  Google Scholar 

Lin Y, Yao M, Wu H, Wu F, Cao S, Ni H, et al. Environmental enrichment implies GAT-1 as a potential therapeutic target for stroke recovery. Theranostics. 2021;11:3760–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo CX, Lin YH, Qian XD, Tang Y, Zhou HH, Jin X, et al. Interaction of nNOS with PSD-95 negatively controls regenerative repair after stroke. J Neurosci. 2014;34:13535–48.

Article  PubMed  PubMed Central  Google Scholar 

Lin YH, Liang HY, Xu K, Ni HY, Dong J, Xiao H, et al. Dissociation of nNOS from PSD-95 promotes functional recovery after cerebral ischaemia in mice through reducing excessive tonic GABA release from reactive astrocytes. J Pathol. 2018;244:176–88.

Article  CAS  PubMed 

留言 (0)

沒有登入
gif