Understanding the Evolving Role of Voluntary Medical Male Circumcision as a Public Health Strategy in Eastern and Southern Africa: Opportunities and Challenges

Auvert B, Taljaard D, Lagarde E, Sobngwi-Tambekou J, Sitta R, Puren A. Randomized, Controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 trial. PLoS Med. 2005;2: e298.

Article  PubMed  PubMed Central  Google Scholar 

Gray RH, Kigozi G, Serwadda D, et al. Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial. The Lancet. 2007;369:657–66.

Article  Google Scholar 

Bailey RC, Moses S, Parker CB, Agot K, Maclean I, Krieger JN, Williams CF, Campbell RT, Ndinya-Achola JO. Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial. The Lancet. 2007;369:643–56.

Article  Google Scholar 

Chiu C, Johnson LF, Jamieson L, Larson BA, Meyer-Rath G. Designing an optimal HIV programme for South Africa: does the optimal package change when diminishing returns are considered? BMC Public Health. 2017. https://doi.org/10.1186/s12889-017-4023-3.

Article  PubMed  PubMed Central  Google Scholar 

Meyer-Rath G, van Rensburg C, Larson B, Jamieson L, Rosen S. Revealed willingness-to-pay versus standard cost-effectiveness thresholds: evidence from the South African HIV Investment Case. PLoS ONE. 2017;12: e0186496.

Article  PubMed  PubMed Central  Google Scholar 

Lukoba B, Simiyu J, Chege W, Kelly S, Minnery M, Sithole L, Shubber Z. Improving allocative efficiency of the HIV response in Kenya: a country-level analysis using the Optima HIV model. Washington, DC: World Bank; 2020.

Book  Google Scholar 

Taramusi I, Sisimayi C, Benedikt C, Cheikh N, Fraser N, Shubber Z, et al. Improving the allocative efficiency of the HIV response across the care cascade in Zimbabwe: findings from a modelling analysis. 2019. https://doi.org/10.1596/33271.

McGillen JB, Stover J, Klein DJ, et al. The emerging health impact of voluntary medical male circumcision in Zimbabwe: an evaluation using three epidemiological models. PLoS ONE. 2018;13: e0199453.

Article  PubMed  PubMed Central  Google Scholar 

Kelly SL, Martin-Hughes R, Stuart RM, et al. The global Optima HIV allocative efficiency model: targeting resources in efforts to end AIDS. The Lancet HIV. 2018;5:e190–8.

Article  PubMed  Google Scholar 

Morris BJ, Moreton S, Krieger JN. Critical evaluation of arguments opposing male circumcision: a systematic review. J Evid Based Med. 2019;12:263–90.

Article  PubMed  PubMed Central  Google Scholar 

• Farley TM, Samuelson J, Grabowski MK, Ameyan W, Gray RH, Baggaley R. Impact of male circumcision on risk of HIV infection in men in a changing epidemic context – systematic review and meta-analysis. J Intern AIDS Soc. 2020. https://doi.org/10.1002/jia2.25490Farley et al. review evidence of VMMC effectiveness, finding the intervention to be similarly effective in randomized controlled trials and in community-based cohorts where VMMC has been implemented. They further estimate that VMMC programs have averted approximately half a million HIV infections over the decade 2008–2018.

Article  Google Scholar 

Sharma SC, Raison N, Khan S, Shabbir M, Dasgupta P, Ahmed K. Male circumcision for the prevention of human immunodeficiency virus (HIV) acquisition: a meta-analysis. BJU Int. 2018;121:515–26.

Article  PubMed  Google Scholar 

Mudimu E, Peebles K, Mukandavire Z, Nightingale E, Sharma M, Medley GF, Klein DJ, Kripke K, Bershteyn A. Individual and community-level benefits of PrEP in western Kenya and South Africa: implications for population prioritization of PrEP provision. PLoS ONE. 2020. https://doi.org/10.1371/journal.pone.0244761.

Article  PubMed  PubMed Central  Google Scholar 

Bershteyn A, Klein DJ, Eckhoff PA. Age-dependent partnering and the HIV transmission chain: a microsimulation analysis. J R Soc Interface. 2013;10:20130613.

Article  PubMed  PubMed Central  Google Scholar 

Hutchinson J. On the influence of circumcision in preventing syphilis. Med Times Gazette. 1855;32:542–3.

Google Scholar 

Auvert B, Sobngwi-Tambekou J, Cutler E, Nieuwoud M, Lissouba P, Puren A, Taljaard D. Effect of male circumcision on the prevalence of high-risk human papillomavirus in young men: results of a randomized controlled trial conducted in orange farm, South Africa. J Infect Dis. 2009;199:14–9.

Article  PubMed  Google Scholar 

Sobngwi-Tambekou J, Taljaard D, Nieuwoudt M, Lissouba P, Puren A, Auvert B. Male circumcision and Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis: observations after a randomised controlled trial for HIV prevention. J Infect Dis. 2009;85:116–20.

CAS  Google Scholar 

Tarnaud C, Lissouba P, Cutler E, Puren A, Taljaard D, Auvert B. Association of low-risk human papillomavirus infection with male circumcision in young men: results from a longitudinal study conducted in orange farm (South Africa). Infect Dis Obstet Gynecol. 2011.

Olesen TB, Munk C, Mwaiselage J, Kahesa C, Rasch V, Frederiksen K, Iftner T, Kjaer SK. Male circumcision and the risk of gonorrhoea, syphilis, HIV and human papillomavirus among men in Tanzania. Int J STD AIDS. 2019;30:1408–16.

Article  PubMed  Google Scholar 

Davis M-A, Gray RH, Grabowski MK, et al. Male circumcision decreases high-risk human papillomavirus viral load in female partners: a randomized trial in Rakai, Uganda. Int J Cancer. 2013;133:1247–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Millett GA, Flores SA, Gary Marks J, Reed B, Herbst JH. Circumcision status and risk of HIV and sexually transmitted infections among men who have sex with men: a meta-analysis. JAMA. 2008;300:1674–84.

Article  CAS  PubMed  Google Scholar 

Canadas MP, Darwich L, Videla S, Sirera G, Coll J, Rafael M-LA, HIV-HPV Study Group. Circumcision and penile human papillomavirus prevalence in human immunodeficiency virus-infected men: heterosexual and men who have sex with men. Clin Microbiol Infect. 2013;19:611–6.

Article  CAS  PubMed  Google Scholar 

Matoga M, Hosseinipour MC, Jewett S, Hoffman IF, Chasela C. Effects of HIV voluntary medical male circumcision programs on sexually transmitted infections. Curr Opin Infect Dis. 2020. https://doi.org/10.1097/QCO.0000000000000696.

Article  PubMed Central  Google Scholar 

Van Howe RS. Sexually transmitted infections and male circumcision: a systematic review and meta-analysis. Urology. 2013:42 pages.

Morris BJ, Hankins CA, Banerjee J, Lumbers ER, Mindel A, Klausner JD, Krieger JN. Does male circumcision reduce women’s risk of sexually transmitted infections, cervical cancer, and associated conditions? Public Health. 2019;7:4.

Google Scholar 

Yuan T, Fitzpatrick T, Ko N-Y, et al. Circumcision to prevent HIV and other sexually transmitted infections in men who have sex with men: a systematic review and meta-analysis of global data. Lancet Glob Health. 2019;7:e436-437.

Article  PubMed  PubMed Central  Google Scholar 

Vallely AJ, MacLaren D, David M, et al. Dorsal longitudinal foreskin cut is associated with reduced risk of HIV, syphilis and genital herpes in men: a cross-sectional study in Papua New Guinea. J Int AIDS Soc. 2017;20:21358.

Article  PubMed  PubMed Central  Google Scholar 

Prodger JL, Kaul R. The biology of how circumcision reduces HIV susceptibility: broader implications for the prevention field. AIDS Res Ther. 2017;14:49.

Article  PubMed  PubMed Central  Google Scholar 

Onywera H, Williamson A-L, Ponomarenko J, Meiring TL. The penile microbiota in uncircumcised and circumcised men: relationships with HIV and human papillomavirus infections and cervicovaginal microbiota. Front Med. 2020;7:383.

Article  Google Scholar 

Mutanekelwa I, Siziya S, Daka V, et al. Prevalence and correlates of voluntary medical male circumcision adverse events among adult males in the Copperbelt Province of Zambia: a cross-sectional study. PLoS ONE. 2021;16: e0256955.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Phili R, Abdool-Karim Q, Ngesa O. Low adverse event rates following voluntary medical male circumcision in a high HIV disease burden public sector prevention programme in South Africa. J Int AIDS Soc. 2014;17:19275.

Article  PubMed  PubMed Central  Google Scholar 

Hellar A, Plotkin M, Lija G, et al. Adverse events in a large-scale VMMC programme in Tanzania: findings from a case series analysis. J Int AIDS Soc. 2019;22: e25369.

Article  PubMed  PubMed Central  Google Scholar 

Victor O, Phiona M, Vernon M, et al. Adverse event trends within a large-scale, routine, voluntary medical male circumcision program in Zimbabwe, 2014–2019. J Acquir Immune Defic Syndr. 2021;88:173–80.

Article  PubMed  PubMed Central  Google Scholar 

Brito A, Korn A, Monteiro L, Mudender F, Maiela A, Come J, Barnhart S, Feldacker C. Need for improved detection of voluntary medical male circumcision adverse events in Mozambique: a mixed-methods assessment. BMC Health Serv Res. 2019;19:855.

Article  PubMed  PubMed Central  Google Scholar 

Feldacker C, Murenje V, Makunike-Chikwinya B, et al. Balancing competing priorities: quantity versus quality within a routine, voluntary medical male circumcision program operating at scale in Zimbabwe. PLoS ONE. 2020;15: e0240425.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kohler PK, Namate D, Barnhart S, et al. Classification and rates of adverse events in a Malawi male circumcision program: impact of quality improvement training. BMC Health Serv Res. 2016. https://doi.org/10.1186/s12913-016-1305-x.

Article  PubMed  PubMed Central  Google Scholar 

Ashengo TA, Grund J, Mhlanga M, et al. Feasibility and validity of telephone triage for adverse events during a voluntary medical male circumcision campaign in Swaziland. BMC Public Health. 2014;14:858.

Article  PubMed  PubMed Central  Google Scholar 

Gilbertson A, Ongili B, Odongo FS, Hallfors DD, Rennie S, Kwaro D, Luseno WK. Voluntary medical male circumcision for HIV prevention among adolescents in Kenya: unintended consequences of pursuing service-delivery targets. PLoS ONE. 2019;14: e0224548.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lawal TA, Oluwabunmi Olapade-Olaopa E. Circumcision and its effects in Africa. Transl Androl Urol. 2017;6:149–57.

Article  PubMed  PubMed Central  Google Scholar 

O’Bryan G, Feldacker C, Ensminger A, et al. Adverse event profile and associated factors following surgical voluntary medical male circumcision in two regions of Namibia, 2015–2018. PLoS ONE. 2021;16: e0258611.

Article 

留言 (0)

沒有登入
gif