Prevalence of anti-leptospiral IgM and detection of pathogenic Leptospira species DNA in neonates presenting with clinical sepsis in Southwestern Uganda

Costa F, Hagan JE, Calcagno J, Kane M, Torgerson P, Martinez-Silveira MS, Stein C, Abela-Ridder B, Ko AI. Global morbidity and mortality of leptospirosis: a systematic review. PLoS Negl Trop Dis. 2015;9: e0003898.

Article  PubMed  PubMed Central  Google Scholar 

Karpagam KB, Ganesh B. Leptospirosis: a neglected tropical zoonotic infection of public health importance—an updated review. Eur J Clin Microbiol Infect Dis. 2020;39:835–46.

Article  CAS  PubMed  Google Scholar 

WHO. Report of the second meeting of the leptospirosis burden epidemiology reference group. Geneva: World Health Organization; 2011.

Google Scholar 

Forbes BA, Sahm DF, Weissfeld AS. Bailey and Scott’s diagnostic microbiology. 12th ed. St Loise: Mosby Elsevier; 2007.

Google Scholar 

Haake DA, Levett PN. Leptospirosis in humans. In: Adler B, editor. Leptospira and leptospirosis. Berlin: Springer; 2015. p. 65–97.

Google Scholar 

Organization WH. Human leptospirosis: guidance for diagnosis, surveillance and control. Geneva: World Health Organization; 2003.

Google Scholar 

Morey RE, Galloway RL, Bragg SL, Steigerwalt AG, Mayer LW, Levett PN. Species-specific identification of Leptospiraceae by 16S rRNA gene sequencing. J Clin Microbiol. 2006;44:3510–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vincent AT, Schiettekatte O, Goarant C, Neela VK, Bernet E, Thibeaux R, Ismail N, Mohd Khalid MKN, Amran F, Masuzawa T. Revisiting the taxonomy and evolution of pathogenicity of the genus Leptospira through the prism of genomics. PLoS Negl Trop Dis. 2019;13: e0007270.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cerqueira GM, Picardeau M. A century of Leptospira strain typing. Infect Genet Evol. 2009;9:760–8.

Article  CAS  PubMed  Google Scholar 

Balamurugan V, Gangadhar NL, Mohandoss N, Thirumalesh SRA, Dhar M, Shome R, Krishnamoorthy P, Prabhudas K, Rahman H. Characterization of leptospira isolates from animals and humans: phylogenetic analysis identifies the prevalence of intermediate species in India. Springerplus. 2013;2:1–9.

Article  Google Scholar 

Chiriboga J, Barragan V, Arroyo G, Sosa A, Birdsell DN, España K, Mora A, Espín E, Mejía ME, Morales M. High prevalence of intermediate Leptospira spp. DNA in febrile humans from urban and rural Ecuador. Emerg Infect Dis. 2015;21:2141.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schiff SJ, Kiwanuka J, Riggio G, Nguyen L, Mu K, Sproul E, Bazira J, Mwanga-Amumpaire J, Tumusiime D, Nyesigire E. Separating putative pathogens from background contamination with principal orthogonal decomposition: evidence for Leptospira in the Ugandan neonatal septisome. Front Med. 2016;3:22.

Article  Google Scholar 

Atherstone C, Picozzi K, Kalema-Zikusoka G. Seroprevalence of Leptospira hardjo in cattle and African buffalos in southwestern Uganda. Am J Trop Med Hyg. 2014;90:288.

Article  PubMed  PubMed Central  Google Scholar 

Evangelista KV, Coburn J. Leptospira as an emerging pathogen: a review of its biology, pathogenesis and host immune responses. Fut Microbiol. 2010;5:1413–25.

Article  Google Scholar 

Shaked Y, Shpilberg O, Samra D, Samra Y. Leptospirosis in pregnancy and its effect on the fetus: case report and review. Clin Infect Dis. 1993;17:241–3.

Article  CAS  PubMed  Google Scholar 

De Vries SG, Visser BJ, Nagel IM, Goris MGA, Hartskeerl RA, Grobusch MP. Leptospirosis in Sub-Saharan Africa: a systematic review. Int J Infect Dis. 2014;28:47–64.

Article  PubMed  Google Scholar 

Torgerson PR, Hagan JE, Costa F, Calcagno J, Kane M, Martinez-Silveira MS, Goris MGA, Stein C, Ko AI, Abela-Ridder B. Global burden of leptospirosis: estimated in terms of disability adjusted life years. PLoS Negl Trop Dis. 2015;9: e0004122.

Article  PubMed  PubMed Central  Google Scholar 

Allan KJ, Biggs HM, Halliday JEB, Kazwala RR, Maro VP, Cleaveland S, Crump JA. Epidemiology of leptospirosis in Africa: a systematic review of a neglected zoonosis and a paradigm for ‘One Health’in Africa. PLoS Negl Trop Dis. 2015;9: e0003899.

Article  PubMed  PubMed Central  Google Scholar 

Dreyfus A, Dyal JW, Pearson R, Kankya C, Kajura C, Alinaitwe L, Kakooza S, Pelican KM, Travis DA, Mahero M. Leptospira seroprevalence and risk factors in health centre patients in Hoima District. Western Uganda PLoS Negl Trop Dis. 2016;10: e0004858.

Article  PubMed  Google Scholar 

Mugalu J, Nakakeeto MK, Kiguli S, Kaddu-Mulindwa DH. Aetiology, risk factors and immediate outcome of bacteriologically confirmed neonatal septicaemia in Mulago hospital, Uganda. Afr Health Sci. 2006;6:120–6.

CAS  PubMed  PubMed Central  Google Scholar 

Kiwanuka J, Bazira J, Mwanga J, Tumusiime D, Nyesigire E, Lwanga N, Warf BC, Kapur V, Poss M, Schiff SJ. The microbial spectrum of neonatal sepsis in Uganda: recovery of culturable bacteria in mother-infant pairs. PLoS ONE. 2013;8: e72775.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bourhy P, Bremont S, Zinini F, Giry C, Picardeau M. Comparison of real-time PCR assays for detection of pathogenic Leptospira spp. in blood and identification of variations in target sequences. J Clin Microbiol. 2011;49:2154–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schoonman L, Swai ES. Risk factors associated with the seroprevalence of leptospirosis, amongst at-risk groups in and around Tanga city, Tanzania. Ann Trop Med Parasitol. 2009;103:711–8.

Article  CAS  PubMed  Google Scholar 

Crump JA, Morrissey AB, Nicholson WL, Massung RF, Stoddard RA, Galloway RL, Ooi EE, Maro VP, Saganda W, Kinabo GD. Etiology of severe non-malaria febrile illness in Northern Tanzania: a prospective cohort study. PLoS Negl Trop Dis. 2013;7: e2324.

Article  PubMed  PubMed Central  Google Scholar 

Biggs HM, Bui DM, Galloway RL, Stoddard RA, Shadomy SV, Morrissey AB, Bartlett JA, Onyango JJ, Maro VP, Kinabo GD. Leptospirosis among hospitalized febrile patients in northern Tanzania. Am J Trop Med Hyg. 2011;85:275.

Article  PubMed  PubMed Central  Google Scholar 

van Well GTJ, Daalderop LA, Wolfs T, Kramer BW. Human perinatal immunity in physiological conditions and during infection. Mol Cell Pediatr. 2017;4:1–11.

Google Scholar 

Rosa MI, dos Reis MF, Simon C, Dondossola E, Alexandre MC, Colonetti T, Meller FO. IgM ELISA for leptospirosis diagnosis: a systematic review and meta-analysis. Cien Saude Colet. 2017;22:4001–12.

Article  PubMed  Google Scholar 

Stoddard RA, Gee JE, Wilkins PP, McCaustland K, Hoffmaster AR. Detection of pathogenic Leptospira spp. through TaqMan polymerase chain reaction targeting the LipL32 gene. Diagn Microbiol Infect Dis. 2009;64:247–55.

Article  CAS  PubMed  Google Scholar 

Ahmed A, Grobusch MP, Klatser PR, Hartskeerl RA. Molecular approaches in the detection and characterization of Leptospira. J Bacteriol Parasitol. 2012;3: e133.

Article  Google Scholar 

留言 (0)

沒有登入
gif