Helping C. difficile to thrive

The microbial environment in the gastrointestinal tract is rich and dynamic, and it influences the establishment of infections by enteric pathogens. Enterococci are a group of opportunistic pathogens that are often associated with the important enteric pathogen Clostridioides difficile. How these two bacteria interact and how Enterococcus species influence C. difficile infection (CDI) are currently unknown. Now, Smith et al. report that expansion of enterococci (Enterococcus faecium and Enterococcus faecalis) in the gut reprogrammes C. difficile metabolism, thus enhancing its pathogenesis.

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