These authors contributed equally: Lulu Hu, Shun Liu, Yong Peng, Ruiqi Ge, Rui Su.

These authors jointly supervised this work: Chuan He, Jianjun Chen, Mengjie Chen, Lulu Hu.

Department of Chemistry, The University of Chicago, Chicago, IL, USA

Lulu Hu, Shun Liu, Yong Peng, Ruiqi Ge, Bryan T. Harada, Qing Dai, Jiangbo Wei, Lisheng Zhang, Ziyang Hao, Liangzhi Luo, Huanyu Wang, Yuru Wang & Chuan He

Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA

Lulu Hu, Shun Liu, Yong Peng, Ruiqi Ge, Bryan T. Harada, Qing Dai, Jiangbo Wei, Lisheng Zhang, Ziyang Hao, Liangzhi Luo, Huanyu Wang, Yuru Wang & Chuan He

Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA

Lulu Hu, Shun Liu, Yong Peng, Ruiqi Ge, Bryan T. Harada, Qing Dai, Jiangbo Wei, Lisheng Zhang, Ziyang Hao, Liangzhi Luo, Huanyu Wang, Yuru Wang & Chuan He

Fudan University Institutes of Biomedical Sciences, Shanghai Cancer Center, Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Shanghai Medical College of Fudan University, Shanghai, China

Lulu Hu

Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL, USA

Shun Liu, Yong Peng & Mengjie Chen

Department of Human Genetics, The University of Chicago, Chicago, IL, USA

Shun Liu, Yong Peng & Mengjie Chen

Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA, USA

Rui Su & Jianjun Chen

Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA

Chamara Senevirathne & Minkui Luo

Program of Pharmacology, Weill Cornell Medical College of Cornell University, New York, NY, USA

Minkui Luo

City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, USA

Jianjun Chen

Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA

Jianjun Chen