Repeated Use of Morphine Induces Anxiety by Affecting a Proinflammatory Cytokine Signaling Pathway in the Prefrontal Cortex in Rats

Ueda H, Ueda M (2009) Mechanisms underlying morphine analgesic tolerance and dependence. Front Biosci (Landmark Ed) 14:5260–5272. https://doi.org/10.2741/3596

Article  CAS  PubMed  Google Scholar 

Watkins LR, Hutchinson MR, Rice KC, Maier SF (2009) The “toll” of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia. Trends Pharmacol Sci 30:581–591. https://doi.org/10.1016/j.tips.2009.08.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Glover EM, Davis M (2008) Anxiolytic-like effects of morphine and buprenorphine in the rat model of fear-potentiated startle: tolerance, cross-tolerance, and blockade by naloxone. Psychopharmacol 198:167–180. https://doi.org/10.1007/s00213-008-1112-0

Article  CAS  Google Scholar 

Motaghinejad M, Karimian SM, Motaghinejad O, Shabab B, Asadighaleni M, Fatima S (2015) The effect of various morphine weaning regimens on the sequelae of opioid tolerance involving physical dependency, anxiety and hippocampus cell neurodegeneration in rats. Fundam Clin Pharmacol 29:299–309. https://doi.org/10.1111/fcp.12121

Article  CAS  PubMed  Google Scholar 

Wilson-Poe AR, Jeong HJ, Vaughan CW (2017) Chronic morphine reduces the readily releasable pool of GABA, a presynaptic mechanism of opioid tolerance. J Physiol 595:6541–6555. https://doi.org/10.1113/jp274157

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koller G, Schwarzer A, Halfter K, Soyka M (2019) Pain management in opioid maintenance treatment. Expert Opin Pharmacother 20:1993–2005. https://doi.org/10.1080/14656566.2019.1652270

Article  CAS  PubMed  Google Scholar 

Mercadante S, Arcuri E, Santoni A (2019) Opioid-induced tolerance and hyperalgesia. CNS Drugs 33:943–955. https://doi.org/10.1007/s40263-019-00660-0

Article  CAS  PubMed  Google Scholar 

Kim J, Ham S, Hong H, Moon C (2016) Im HI Brain reward circuits in morphine addiction. Mol Cells 39:645–53. https://doi.org/10.14348/molcells.2016.0137

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koob GF, Volkow ND (2016) Neurobiology of addiction: a neurocircuitry analysis. Lancet Psychiatry 3:760–773. https://doi.org/10.1016/s2215-0366(16)00104-8

Article  PubMed  PubMed Central  Google Scholar 

Kelley AE, Domesick VB (1982) The distribution of the projection from the hippocampal formation to the nucleus accumbens in the rat: an anterograde- and retrograde-horseradish peroxidase study. Neurosci 7:2321–2335

Article  CAS  Google Scholar 

Sesack SR, Pickel VM (1990) In the rat medial nucleus accumbens, hippocampal and catecholaminergic terminals converge on spiny neurons and are in apposition to each other. Brain Res 527:266–279

Article  CAS  PubMed  Google Scholar 

Ong WY, Stohler CS, Herr DR (2019) Role of the prefrontal cortex in pain processing. Mol Neurobiol 56:1137–1166. https://doi.org/10.1007/s12035-018-1130-9

Article  CAS  PubMed  Google Scholar 

Dixon ML, Thiruchselvam R, Todd R, Christoff K (2017) Emotion and the prefrontal cortex: an integrative review. Psychol Bull 143:1033–1081. https://doi.org/10.1037/bul0000096

Article  PubMed  Google Scholar 

Adhikari A, Topiwala MA, Gordon JA (2010) Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety. Neuron 65:257–269. https://doi.org/10.1016/j.neuron.2009.12.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lowery-Gionta EG, Crowley NA, Bukalo O, Silverstein S, Holmes A, Kash TL (2018) Chronic stress dysregulates amygdalar output to the prefrontal cortex. Neuropharmacol 139:68–75. https://doi.org/10.1016/j.neuropharm.2018.06.032

Article  CAS  Google Scholar 

Yang Y, Wang JZ (2017) From structure to behavior in basolateral amygdala-hippocampus circuits. Front Neural Circuits 11:86. https://doi.org/10.3389/fncir.2017.00086

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zaki Y, Mau W, Cincotta C, Monasterio A, Odom E, Doucette E et al (2022) Hippocampus and amygdala fear memory engrams re-emerge after contextual fear relapse. Neuropsychopharmacol 47:1992–2001. https://doi.org/10.1038/s41386-022-01407-0

Article  CAS  Google Scholar 

McEwen BS, Morrison JH (2013) The brain on stress: vulnerability and plasticity of the prefrontal cortex over the life course. Neuron 79:16–29. https://doi.org/10.1016/j.neuron.2013.06.028

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mah L, Szabuniewicz C, Fiocco AJ (2016) Can anxiety damage the brain? Curr Opin Psychiatry 29:56–63. https://doi.org/10.1097/yco.0000000000000223

Article  PubMed  Google Scholar 

Koob GF, Volkow ND (2010) Neurocircuitry of addiction. Neuropsychopharmacol 35:217–238. https://doi.org/10.1038/npp.2009.110

Article  Google Scholar 

Listos J, Łupina M, Talarek S, Mazur A, Orzelska-Górka J, Kotlińska J (2019) The mechanisms involved in morphine addiction: an overview. Int J Mol Sci 20 https://doi.org/10.3390/ijms20174302

Spetea M, Asim MF, Wolber G, Schmidhammer H (2013) The µ opioid receptor and ligands acting at the µ opioid receptor, as therapeutics and potential therapeutics. Curr Pharm Des 19:7415–7434. https://doi.org/10.2174/13816128113199990362

Article  CAS  PubMed  Google Scholar 

Song P, Zhao ZQ (2001) The involvement of glial cells in the development of morphine tolerance. Neurosci Res 39:281–286. https://doi.org/10.1016/s0168-0102(00)00226-1

Article  CAS  PubMed  Google Scholar 

Eidson LN, Murphy AZ (2019) Inflammatory mediators of opioid tolerance: Implications for dependency and addiction. Peptides 115:51–58. https://doi.org/10.1016/j.peptides.2019.01.003

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eidson LN, Murphy AZ (2013) Blockade of Toll-like receptor 4 attenuates morphine tolerance and facilitates the pain relieving properties of morphine. J Neurosci 33:15952–15963. https://doi.org/10.1523/jneurosci.1609-13.2013

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu R, Li JX (2020) Toll-like receptor 4 signaling and drug addiction. Front Pharmacol 11:603445. https://doi.org/10.3389/fphar.2020.603445

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jacobsen JH, Watkins LR, Hutchinson MR (2014) Discovery of a novel site of opioid action at the innate immune pattern-recognition receptor TLR4 and its role in addiction. Int Rev Neurobiol 118:129–163. https://doi.org/10.1016/b978-0-12-801284-0.00006-3

Article  PubMed  Google Scholar 

Zhang Y, Li H, Li Y, Sun X, Zhu M, Hanley G et al (2011) Essential role of toll-like receptor 2 in morphine-induced microglia activation in mice. Neurosci Lett 489:43–47. https://doi.org/10.1016/j.neulet.2010.11.063

Article  CAS  PubMed  Google Scholar 

Liu QF, Li L, Guo YQ, Li X, Mou ZD, Wang X et al (2016) Injection of toll-like receptor 4 siRNA into the ventrolateral periaqueductal gray attenuates withdrawal syndrome in morphine-dependent rats. Arch Ital Biol 154:133–42. https://doi.org/10.12871/00039829201644

Article  CAS  PubMed  Google Scholar 

Thomas JHL, Lui L, Abell A, Tieu W, Somogyi AA, Bajic JE et al (2022) Toll-like receptors change morphine-induced antinociception, tolerance and dependence: studies using male and female TLR and signalling gene KO mice. Brain Behav Immun 102:71–85. https://doi.org/10.1016/j.bbi.2022.02.001

Article  CAS  PubMed  Google Scholar 

Shafie A, Moradi F, Izadpanah E, Mokarizadeh A, Moloudi MR, Nikzaban M et al (2015) Neuroprotection of donepezil against morphine-induced apoptosis is mediated through toll-like receptors. Eur J Pharmacol 764:292–297. https://doi.org/10.1016/j.ejphar.2015.07.027

Article  CAS  PubMed  Google Scholar 

Wang X, Loram LC, Ramos K, de Jesus AJ, Thomas J, Cheng K et al (2012) Morphine activates neuroinflammation in a manner parallel to endotoxin. Proc Natl Acad Sci U S A 109:6325–6330. https://doi.org/10.1073/pnas.1200130109

Article  PubMed  PubMed Central  Google Scholar 

Liu DQ, Zhou YQ, Gao F (2019) Targeting cytokines for morphine tolerance: a narrative review. Curr Neuropharmacol 17:366–376. https://doi.org/10.2174/1570159x15666171128144441

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barbierato M, Zusso M, Skaper SD, Giusti P (2015) MicroRNAs: emerging role in the endogenous μ opioid system. CNS Neurol Disord Drug Targets 14:239–250. https://doi.org/10.2174/1871527314666150116123932

Article  CAS  PubMed  Google Scholar 

Huang J, Wang J, Guo Q, Zou W (2019) Emerging roles of microRNAs in morphine tolerance. J Pain Res 12:1139–1147. https://doi.org/10.2147/jpr.s187592

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sartor GC, St Laurent G 3rd, Wahlestedt C (2012) The emerging role of non-coding RNAs in drug addiction. Front Genet 3:106. https://doi.org/10.3389/fgene.2012.00106

Article  CAS 

留言 (0)

沒有登入
gif