Block RC, Harris WS, Reid KJ, Sands SA, Spertus JA. EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls. Atherosclerosis. 2008;197(2):821–8.

Article  CAS  PubMed  Google Scholar 

Block RC, Harris WS, Reid KJ, Spertus JA. Omega-6 and trans fatty acids in blood cell membranes: a risk factor for acute coronary syndromes? Am Heart J. 2008;156(6):1117–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harris WS. The omega-6/omega-3 ratio and cardiovascular disease risk: uses and abuses. Curr Atheroscler Rep. 2006;8(6):453–9.

Article  CAS  PubMed  Google Scholar 

Harris WS. Omega-3 fatty acids and cardiovascular disease: a case for omega-3 index as a new risk factor. Pharmacol Res. 2007;55(3):217–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Külzow N, Witte AV, Kerti L, Grittner U, Schuchardt JP, Hahn A, et al. Impact of omega-3 fatty acid supplementation on memory functions in healthy older adults. J Alzheimers Dis. 2016;51(3):713–25.

Article  PubMed  Google Scholar 

Sijben JW, Calder PC. Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease. Proc Nutr Soc. 2007;66(2):237–59.

Article  CAS  PubMed  Google Scholar 

Chapkin RS, McMurray DN, Lupton JR. Colon cancer, fatty acids and anti-inflammatory compounds. Curr Opin Gastroenterol. 2007;23(1).

Rigano F, Arena P, Mangraviti D, Donnarumma D, Dugo P, Donato P, et al. Identification of high-value generating molecules from the wastes of tuna fishery industry by liquid chromatography and gas chromatography hyphenated techniques with automated sample preparation. J Sep Sci. 2021;44(8):1571–80.

Article  CAS  PubMed  Google Scholar 

Shahidi F. Nutraceutical and specialty lipids and their co-products. 1st ed. Boca Raton, FL: CRC Press; 2006.

Book  Google Scholar 

Shahidi F. Omega-3 fatty acids in health and disease. In: Hernandez EM, Hosokawa M, editors. Omega-3 oils - applications in functional foods. Urbana, Illinois: AOCS Press; 2011. p. 1–29.

Google Scholar 

Calder PC. Immunomodulation by omega-3 fatty acids. Prostaglandins Leukot Essent Fat Acids. 2007;77(5):327–35.

Article  CAS  Google Scholar 

Yaqoob P, Pala HS, Cortina-Borja M, Newsholme EA, Calder PC. Encapsulated fish oil enriched in α-tocopherol alters plasma phospholipid and mononuclear cell fatty acid compositions but not mononuclear cell functions. Eur J Clin Invest. 2000;30:260–74.

Article  CAS  PubMed  Google Scholar 

Srigley CT, Rader JI. Content and composition of fatty acids in marine oil omega-3 supplements. J Agric Food Chem. 2014;62(29):7268–78.

Article  PubMed  Google Scholar 

Micalizzi G, Ragosta E, Farnetti S, Dugo P, Tranchida PQ, Mondello L, et al. Rapid and miniaturized qualitative and quantitative gas chromatography profiling of human blood total fatty acids. Anal Bioanal Chem. 2020;412(10):2327–37.

Article  CAS  PubMed  Google Scholar 

El-Hamdy AH, Christie W. Preparation of methyl esters of fatty acids with trimethylsulphonium hydroxid an appraisal. J Chromatogr A. 1993;630:438–41.

Article  Google Scholar 

Galli C, Risé P, Ghezzi S, Marangoni F. Fast Determination of fatty acids in whole blood collected from fingertips: application to the assessment of fatty acid patterns (and various indexes) in population studies. World Rev Nutr Diet. 2009;100:35–45.

Article  CAS  PubMed  Google Scholar 

Lepage G, Roy CC. Direct transesterification of all classes of lipids in a one-step reaction. J Lipid Res. 1986;27(1):114–20.

Article  CAS  PubMed  Google Scholar 

Rizzo AM, Montorfano G, Negroni M, Adorni L, Berselli P, Corsetto P, et al. A rapid method for determining arachidonic:eicosapentaenoic acid ratios in whole blood lipids: correlation with erythrocyte membrane ratios and validation in a large Italian population of various ages and pathologies. Lipids Health Dis. 2010;9:7.

Article  PubMed  PubMed Central  Google Scholar 

Certificate of Analysis, Standard Reference Material 1950 metabolites in human plasma (accessed October 06, 2021). Available from: https://www-s.nist.gov/srmors/view_cert.cfm?srm=1950.

Certificate of Analysis, Standard Reference Material 3275 Omega-3 and omega-6 fatty acids in fish oil (accessed October 06, 2021). Available from: https://www-s.nist.gov/srmors/quickSearch.cfm?srm=3275.

Blumberg LM, Klee MS. Optimal heating rate in gas chromatography. J Microcolumn Sep. 2000;12:508–14.

Article  CAS  Google Scholar 

Leclercq PA, Novak J. Open tubular column. In: Quantitative analysis by gas chromatography, 2nd ed. Marcel Dekker Inc., New York; 1987. pp. 247–317.

Mondello L, Tranchida PQ, Dugo P, Dugo G. Rapid, micro-scale preparation and very fast gas chromatographic separation of cod liver oil fatty acid methyl esters. J Pharm Biomed Anal. 2006;5(41):1566–70.

Article  Google Scholar 

Benner BA Jr, Schantz MM, Powers CD, Schleicher RL, Camara JE, Sharpless KE, et al. Standard reference material (SRM) 2378 fatty acids in frozen human serum. Certification of a clinical SRM based on endogenous supplementation of polyunsaturated fatty acids. Anal Bioanal Chem. 2018;410:2321–9.

Schantz MM, Powers CD, Schleicher RL, Betz JM, Wise SA. Interlaboratory analytical comparison of fatty acid concentrations in serum or plasma. Clin Chim Acta. 2016;462:148–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferreri C, Chatgilialoglu C. Membrane lipidomics for personalized health. 1st ed. Ltd: United Kingdom: John Wiley & Sons; 2015.

Guillou H, Zadravec D, Martin PGP, Jacobsson A. The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice. Prog Lipid Res. 2010;49(2):186–99.

Article  CAS  PubMed  Google Scholar 

Sears B. The Omega RX Zone: the miracle of the new high-dose fish oil. United Kingdom: Harper Collins Publishers Ltd.; 2003.

Google Scholar 

Chee KM, Gong JX, Rees DM, Meydani M, Ausman L, Johnson J, et al. Fatty acid content of marine oil capsules. Lipids. 1990;25(9):523–8.

Article  CAS  PubMed  Google Scholar 

US Food and Drug Administration, Petition for a health claim for eicosapentaenoic acid and docosahexaenoic acid and reduction of blood pressure in the general population. 2019.

Ackman RG, Ratnayake WMN, Macpherson EJ. EPA and DHA contents of encapsulated fish oil products. J Am Oil Chem Soc. 1989;66(8):1162–4.

Article  CAS  Google Scholar