Viruses, Vol. 14, Pages 2686: Molecular Mechanism and Role of Japanese Encephalitis Virus Infection in Central Nervous System-Mediated Diseases

Australia19952 in 1995, 2 in 1998, and 1 in 2022Viral antigen detection, JEV-specific antibody detection, reverse passive hemagglutination, staphylococcal co-agglutination tests, ELISA, qPCR, RT-PCR, RT-LAMPMBDV, Fever relief medicines, plenty of fluid3 cases69 million dollar program to control JEV infection, including mosquito control, vaccination and sentinel pig surveillance programs[35]Bangladesh197722 patients with 7 deaths in 1977Viral antigen detection, JEV-specific antibody detection, ELISA, qPCR, RT-PCRFever and pain relief medicines, plenty of fluid0.6–2.7 cases/lakh-[9,36]Bhutan--ELISA, PCRFever and pain relief medicines, fluid-Integrated national vaccination program[8]Brunei--ELISA, PCRFever and pain relief medicine, plenty of fluid--[13]Cambodia1947-ELISA, PCRLAV-SA14-14-2 vaccine, fever and pain relief medicines, plenty of fluid11.1 cases/lakhNational vaccination program[13]China1940s1960–1970 with morbidity >10 cases/lakhViral antigen detection, JEV-specific antibody detection, reverse passive hemagglutination, staphylococcal co-agglutination tests, ELISA, qPCR, RT-PCR, RT-LAMPLAV-SA14-14-2 vaccine, MBDV, fever and pain relief medicines, plenty of fluid0.1–0.9 cases/lakhExpanded program on immunization to reduce JE[37]Guam194746 reported cases-Fever relief medicines, plenty of fluid--[13]India19505700 cases with 1315 deaths in 2005Viral antigen detection, JEV-specific antibody detection, reverse passive hemagglutination, staphylococcal co-agglutination tests, ELISA, qPCR, RT-PCR, RT-LAMPLAV-SA14-14-2 vaccine, fever and pain relief medicines, plenty of fluid15 cases/lakhGovernment immunization program[38]Indonesia1974-JEV-specific antibody detection, ELISA, PCR, RT-PCRFever and pain relief medicines, plenty of fluid8.2 cases/lakhNo vaccination program[9,39]Japan1933Mainly before 1960Viral antigen detection, JEV-specific antibody detection, reverse passive hemagglutination, staphylococcal co-agglutination tests, ELISA, qPCR, RT-PCRVCDV-Bejing-I vaccine, pain and fever relief medicines<10 casesVaccination program[9]Laos1989-JEV-specific antibody detection in the CSFFever and pain relief medicines, fluids-JEV vaccination in 2013[40]Malaysia1952154 cases with 42 deaths in 1999Viral antigen detection, JEV-specific antibody detection, ELISA, qPCRMBDV, fever relief medicines 4.3 cases/lakhJE vaccination was introduced in July 2001, and the vaccination was only practiced in Sarawak and formalin-activated mouse-derived JE vaccine (Biken, Japan) is used in Malaysia[41]Myanmar19685 cases with 4 deaths in 1947 and 43 with 32 deaths in 1948Viral antigen detection, JEV-specific antibody detection, ELISA, qPCR, RT-PCRFever and pain relief medicines, plenty of fluid-National vaccination program[9,13]Nepal19782040 cases with 205 deaths in 2005JEV-specific antibody detection, ELISALASV-SA14-14-2 vaccine, fever relief medicines1.3 cases/lakhNational JE prevention and control program in Kathmandu valley [31]Pakistan1980s-JEV-specific antibody detectionFever relief medicines-No vaccination programs[9]Papua New Guinea1995-JEV-specific antibody detection, ELISA, PCRFever relief medicines--[42]Philippines1950s-----[13]Saipan, USA19901990JEV-specific antibody detection in CSF, ELISAFever relief medicines-no vaccination programs[43]Singapore1952-Viral antigen detection, JEV-specific antibody detection, reverse passive hemagglutination, staphylococcal co-agglutination tests, ELISA, qPCR, RT-PCRFever relief medicines<5 casesVaccination programs reduce JE case[9,13]Republic of Korea1946-JEV-specific antibody detection in serum and CSF, ELISA, PRNT, PCRMBDV, fever relief medicines 0.01–0.08 cases/lakh and <10 cases/yearSuccessful vaccination program for three decades in the Republic of Korea[44]Sri Lanka1968-ELISA, PCRFever relief medicines<100 casesJE vaccination program[9,13]China Taiwan19381960–1970 with morbidity ~12.4 cases/lakhViral antigen detection, JEV-specific antibody detection, ELISA, qPCR, RT-PCRMBDV, Fever relief medicines, plenty of fluid0.03/lakhTaiwan National Infectious Disease Statistics System–Japanese Encephalitis, Self-reporting through the toll-free 1922 hotline or local public health authority.[45]Thailand1961-RT-PCRMBD vaccine, fever relief medicines 300 cases/yearvaccination program[9,13]Vietnam1960--MBDV, fever relief medicines 1–8 cases/lakhvaccination program (from 1997)[9,13]

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