Li R, Zhu J. Effects of aneuploidy on cell behaviour and function. Nat Rev Mol Cell Biol. 2022;4:250–65. https://doi.org/10.1038/s41580-021-00436.

Article  CAS  Google Scholar 

Thomas C, Cavazza T, Schuh M. Aneuploidy in human eggs: contributions of the meiotic spindle. Biochem Soc Trans. 2021;49(1):107–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Currie CE, Ford E, Benham Whyte L, Taylor DM, Mihalas BP, Erent M, et al. The first mitotic division of human embryos is highly error prone. Nat Commun. 2022;13(1):6755.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Palmerola KL, Amrane S, De Los Angeles A, Xu S, Wang N, de Pinho J, et al. Replication stress impairs chromosome segregation and preimplantation development in human embryos. Cell. 2022;185(16):2988-3007 e20.

Article  CAS  PubMed  Google Scholar 

Kort DH, Chia G, Treff NR, Tanaka AJ, Xing T, Vensand LB, et al. Human embryos commonly form abnormal nuclei during development: a mechanism of DNA damage, embryonic aneuploidy, and developmental arrest. Hum Reprod. 2016;31(2):312–23.

CAS  PubMed  Google Scholar 

Daughtry BL, Rosenkrantz JL, Lazar N, Redmayne N, Nevonen KA, Carbone L, et al. Aneuploidy tolerance in rhesus macaque pre-implantation embryos via micronuclei formation, cellular fragmentation, and blastomere exclusion. Reprod Fertil Dev. 2016;29(1):110–1.

Article  Google Scholar 

Daughtry BL, Rosenkrantz JL, Lazar NH, Fei SS, Redmayne N, Torkenczy KA, et al. Single-cell sequencing of primate preimplantation embryos reveals chromosome elimination via cellular fragmentation and blastomere exclusion. Genome Res. 2019;29(3):367–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ottolini CS, Kitchen J, Xanthopoulou L, Gordon T, Summers MC, Handyside AH. Tripolar mitosis and partitioning of the genome arrests human preimplantation development in vitro. Sci Rep. 2017;7(1):9744.

Article  PubMed  PubMed Central  Google Scholar 

McCoy RC, Newnham LJ, Ottolini CS, Hoffmann ER, Chatzimeletiou K, Cornejo OE, et al. Tripolar chromosome segregation drives the association between maternal genotype at variants spanning PLK4 and aneuploidy in human preimplantation embryos. Hum Mol Genet. 2018;27(14):2573–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Neitzel H, Varon R, Chughtai S, Dartsch J, Dutrannoy-Tonsing V, Nurnberg P, et al. Transmission ratio distortion of mutations in the master regulator of centriole biogenesis PLK4. Hum Genet. 2022;141(11):1785–94.

Article  CAS  PubMed  PubMed Central  Google Scholar