Osthole increases the radiosensitivity of hepatoma cells by inhibiting GSK-3β/AMPK/mTOR pathway-controlled glycolysis

Alves AP, Mamede AC, Alves MG, Oliveira PF, Rocha SM, Botelho MF, Maia CJ (2019) Glycolysis inhibition as a strategy for hepatocellular carcinoma treatment? Curr Cancer Drug Targets 19:26–40

Article  PubMed  CAS  Google Scholar 

Bae H, Lee JY, Song J, Song G, Lim W (2021) Osthole interacts with an ER-mitochondria axis and facilitates tumor suppression in ovarian cancer. J Cell Physiol 236:1025–1042

Article  PubMed  CAS  Google Scholar 

Bhatt AN, Chauhan A, Khanna S, Rai Y, Singh S, Soni R, Kalra N, Dwarakanath BS (2015) Transient elevation of glycolysis confers radio-resistance by facilitating DNA repair in cells. BMC Cancer 15:335

Article  PubMed  PubMed Central  Google Scholar 

Che YL, Li J, Li ZJ, Li J, Wang S, Yan Y, Zou K, Zou LJ (2018) Osthole enhances antitumor activity and irradiation sensitivity of cervical cancer cells by suppressing ATM/NF-κB signaling. Oncol Rep 40:737–747

PubMed  PubMed Central  CAS  Google Scholar 

Chen CP (2019) Role of radiotherapy in the treatment of hepatocellular carcinoma. J Clin Transl Hepatol 7:183–190

Article  PubMed  PubMed Central  Google Scholar 

Chen ZQ, Xie H, Hu MM, Huang TY, Hu YN, Sang N, Zhao YL (2020) Recent progress in treatment of hepatocellular carcinoma. Am J Cancer Res 10:2993–3036

PubMed  PubMed Central  CAS  Google Scholar 

Fan H, Wu YY, Yu SY, Li XM, Wang AY, Wang SJ, Chen WX, Lu Y (2021) Critical role of mTOR in regulating aerobic glycolysis in carcinogenesis (Review). Int J Oncol 58(1):9–19

Article  PubMed  CAS  Google Scholar 

Fang GX, Zhang PL, Liu JF, Zhang X, Zhu XJ, Li R, Wang HY (2019) Inhibition of GSK-3β activity suppresses HCC malignant phenotype by inhibiting glycolysis via activating AMPK/mTOR signaling. Cancer Lett 463:11–26

Article  PubMed  CAS  Google Scholar 

Faubert B, Boily G, Izreig S, Griss T, Samborska B, Dong ZF, Dupuy F, Chambers C, Fuerth BJ, Viollet B, Mamer OA, Avizonis D, DeBerardinis RJ, Siegel PM, Jones RG (2013) AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. Cell Metab 17:113–124

Article  PubMed  CAS  Google Scholar 

Guo L, Chen D, Yin X, Shu QF (2019) GSK-3 beta promotes cell migration and inhibits autophagy by mediating the AMPK pathway in breast cancer. Oncol Res 27:487–494

Article  PubMed  PubMed Central  Google Scholar 

Hirschhaeuser F, Sattler UG, Mueller-Klieser W (2011) Lactate: a metabolic key player in cancer. Cancer Res 71:6921–6925

Article  PubMed  CAS  Google Scholar 

Huang CY, Hsieh FS, Wang CY, Chen LJ, Chang SS, Tsai MH, Huang MH, Kuo CW, Shih CT, Chao T, Chen KF (2018) Palbociclib enhances radiosensitivity of hepatocellular carcinoma and cholangiocarcinoma via inhibiting ataxia telangiectasia-mutated kinase-mediated DNA damage response. Eur J Cancer 102:10–22

Article  PubMed  CAS  Google Scholar 

Huangfu MJ, Wei RM, Wang J, Qin JL, Yu D, Guan X, Li XM, Fu ML, Liu HP, Chen X (2021) Osthole induces necroptosis via ROS overproduction in glioma cells. FEBS Open Bio 11:456–467

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jia CH, Zhao Y, Huang H, Fan K, Xie T, Xie ML (2022) Apigenin sensitizes radiotherapy of mouse subcutaneous glioma through attenuations of cell stemness and DNA damage repair by inhibiting NF-κB/HIF-1α-mediated glycolysis. J Nutr Biochem 107:109038

Article  PubMed  CAS  Google Scholar 

Lee WH, Lin RJ, Lin SY, Chen YC, Lin HM, Liang YC (2011) Osthole enhances glucose uptake through activation of AMP-activated protein kinase in skeletal muscle cells. J Agric Food Chem 59:12874–12881

Article  PubMed  CAS  Google Scholar 

Lin JT, Song T, Li C, Mao WF (2020) GSK-3β in DNA repair, apoptosis, and resistance of chemotherapy, radiotherapy of cancer. Biochim Biophys Acta Mol Cell Res 1867:118659

Article  PubMed  CAS  Google Scholar 

Lin SC, Hardie DG (2018) AMPK: sensing glucose as well as cellular energy status. Cell Metab 27:299–313

Article  PubMed  CAS  Google Scholar 

Lin ZK, Liu J, Jiang GQ, Tan G, Gong P, Luo HF, Li HM, Du J, Ning Z, Xin Y, Wang ZY (2017) Osthole inhibits the tumorigenesis of hepatocellular carcinoma cells. Oncol Rep 37:1611–1618

Article  PubMed  CAS  Google Scholar 

Liu KX, Everdell E, Pal S, Haas-Kogan DA, Milligan MG (2021) Harnessing lactate metabolism for radiosensitization. Front Oncol 11:672339

Article  PubMed  PubMed Central  Google Scholar 

Mo Y, Wu Y, Li X, Rao H, Tian XX, Wu DN, Qiu ZP, Zheng GH, Hu JJ (2020) Osthole delays hepatocarcinogenesis in mice by suppressing AKT/FASN axis and ERK phosphorylation. Eur J Pharmacol 867:172788

Article  PubMed  CAS  Google Scholar 

Nagini S, Sophia J, Mishra R (2019) Glycogen synthase kinases: moonlighting proteins with theranostic potential in cancer. Semin Cancer Biol 56:25–36

Article  PubMed  CAS  Google Scholar 

Park W, Park S, Song G, Lim W (2019) Inhibitory effects of osthole on human breast cancer cell progression via induction of cell cycle arrest, mitochondrial dysfunction, and ER stress. Nutrients 11(11):2777

Article  PubMed  PubMed Central  CAS  Google Scholar 

Peng L, Huang YT, Chen J, Zhuang YX, Zhang F, Chen JY, Zhou L, Zhang DH (2018) Osthole sensitizes with radiotherapy to suppress tumorigenesis of human nasopharyngeal carcinoma in vitro and in vivo. Cancer Manag Res 10:5471–5477

Article  PubMed  PubMed Central  CAS  Google Scholar 

Pliszka M, Szablewski L (2021) Glucose transporters as a target for anticancer therapy. Cancers 13(16):4184

Article  PubMed  PubMed Central  CAS  Google Scholar 

Qi ZG, Zhao X, Zhong W, Xie ML (2016) Osthole improves glucose and lipid metabolism via modulation of PPARα/γ-mediated target gene expression in liver, adipose tissue, and skeletal muscle in fatty liver rats. Pharm Biol 54:882–888

Article  PubMed  CAS  Google Scholar 

Shokoohinia Y, Jafari F, Mohammadi Z, BazvandiL HL, Chow N, Bhattacharyya P, Farzaei MH, Farooqi AA, Nabavi SM, Yerer MB, Bishayee A (2018) Potential anticancer properties of osthol: a comprehensive mechanistic review. Nutrients 10(1):36

Article  PubMed  PubMed Central  Google Scholar 

Tang L, Wei F, Wu YF, He Y, Shi L, Xiong F, Gong ZJ, Guo C, Li XY, Deng H, Cao K, Zhou M, Xiang B, Li XL, Li Y, Li GY, Xiong W, Zeng ZY (2018) Role of metabolism in cancer cell radioresistance and radiosensitization methods. J Exp Clin Cancer Res 37:87

Article  PubMed  PubMed Central  Google Scholar 

Yang XG, Lu Y, Hang JJ, Zhang JF, Zhang TN, Hou YM, Liu J, Lai ST, Luo DW, Wang LW, Hua R, Lin YL (2020) Lactate-modulated immunosuppression of myeloid-derived suppressor cells contributes to the radioresistance of pancreatic cancer. Cancer Immunol Res 8:1440–1451

Article  PubMed  CAS  Google Scholar 

Yu L, Sun YF, Li JJ, Wang Y, Zhu YX, Shi Y, Fan XJ, Zhou JD, Bao Y, Xiao J, Cao K, Cao PG (2017) Silencing the girdin gene enhances radio-sensitivity of hepatocellular carcinoma via suppression of glycolytic metabolism. J Exp Clin Cancer Res 36:110

Article  PubMed  PubMed Central  Google Scholar 

Zahra K, Dey T, Ashish MSP, Pandey U (2020) Pyruvate kinase M2 and cancer: the role of PKM2 in promoting tumorigenesis. Front Oncol 10:159

Article  PubMed  PubMed Central  Google Scholar 

Zhao Y, Huang H, Jia CH, Fan K, Xie T, Zhu ZY, Xie ML (2021) Apigenin increases radiosensitivity of glioma stem cells by attenuating HIF-1α-mediated glycolysis. Med Oncol 38:131

Article  PubMed  CAS  Google Scholar 

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